Top-down fabrication of shape-controlled, monodisperse nanoparticles for biomedical applications

Fu, Xinxin; Cai, Jingxuan; Zhang, Xiang; Li, Wen‐Di; Ge, Haixiong; Hu, Yong

doi:10.1016/j.addr.2018.07.006

Cited by 140 publications

(104 citation statements)

References 236 publications

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“…Su et al (2015) have successfully used this method for the nanofabrication of submicron PLGA grooves for the control of the length and direction of retraction fibers during cell division. The major drawback of this method is the residual interconnecting layer on the substrate base that prevents the formation of isolated nanostructures (Fu et al, 2018). The PRINT (particle replication in non-wetting template) technique involves the preparation of the PLGA-drug solution matrix and casting it on a delivering sheet.…”

Section: Nanoimprint Lithography and The Print Techniquementioning

confidence: 99%

The Design of Poly(lactide-co-glycolide) Nanocarriers for Medical Applications

Essa

Kondiah

Choonara

et al. 2020

Front. Bioeng. Biotechnol.

139

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Polymeric biomaterials have found widespread applications in nanomedicine, and poly(lactide-co-glycolide), (PLGA) in particular has been successfully implemented in numerous drug delivery formulations due to its synthetic malleability and biocompatibility. However, the need for preconception in these formulations is increasing, and this can be achieved by selection and elimination of design variables in order for these systems to be tailored for their specific applications. The starting materials and preparation methods have been shown to influence various parameters of PLGA-based nanocarriers and their implementation in drug delivery systems, while the implementation of computational simulations as a component of formulation studies can provide valuable information on their characteristics. This review provides a critical summary of the synthesis and applications of PLGA-based systems in bio-medicine and outlines experimental and computational design considerations of these systems.

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Section: Nanoimprint Lithography and The Print Techniquementioning

confidence: 99%

The Design of Poly(lactide-co-glycolide) Nanocarriers for Medical Applications

Essa

Kondiah

Choonara

et al. 2020

Front. Bioeng. Biotechnol.

139

View full text Add to dashboard Cite

show abstract

“…So far, numerous types of nanoparticles have been fabricated to precisely adapt or respond to magnetic fields, temperature, ultrasound, pH/redox/hypoxic microenvironments, enzymes, light, among others . This responsiveness may trigger changes in nanoparticles color, shape, size or originate complete disruption and prompt cargo release . Adding to this, nanoparticles physicochemical properties have received significant focus due to their influence in the overall biological performance of these systems.…”

Section: Cell–biomaterials Assembliesmentioning

confidence: 99%

Advanced Bottom‐Up Engineering of Living Architectures

et al. 2019

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Bottom‐up tissue engineering is a promising approach for designing modular biomimetic structures that aim to recapitulate the intricate hierarchy and biofunctionality of native human tissues. In recent years, this field has seen exciting progress driven by an increasing knowledge of biological systems and their rational deconstruction into key core components. Relevant advances in the bottom‐up assembly of unitary living blocks toward the creation of higher order bioarchitectures based on multicellular‐rich structures or multicomponent cell–biomaterial synergies are described. An up‐to‐date critical overview of long‐term existing and rapidly emerging technologies for integrative bottom‐up tissue engineering is provided, including discussion of their practical challenges and required advances. It is envisioned that a combination of cell–biomaterial constructs with bioadaptable features and biospecific 3D designs will contribute to the development of more robust and functional humanized tissues for therapies and disease models, as well as tools for fundamental biological studies.

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“…In recent years, Particle Replication In Non-wetting Templates (PRINT), an advanced unique so lithography particle moulding process, has been gaining interest. [140][141][142][143] The PRINT process enables the specic design and large-scale synthesis of well-dened micro-and nanoparticles with uniformed size and shape. In addition, a double usage of spray-drying technique serves as a promising large-scale method to assemble lipids onto nanoparticle surfaces.…”

Section: Challenges For Current Nanoparticle Formulationsmentioning

confidence: 99%