Tooth transplantation and replantation: Biological insights towards therapeutic improvements

Ideno, Hisashi; Komatsu, Koichiro; Nakashima, Kazuhisa; Nifuji, Akira

doi:10.1002/dvg.23496

Cited by 4 publications

(1 citation statement)

References 56 publications

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“…Long-term follow-up and monitoring must be performed after grafting to assess its success. Grafting often results in poor outcomes, with two major complications: tooth ankylosis and root resorption 10 .…”

Section: Introduction and Importancementioning

confidence: 99%

Bone remodeling of the sinus floor observed 19 years after third molar transplantation to close a maxillary defect: a case report

Grün

Pfaffeneder-Mantai

Bandura

et al. 2023

Annals of Medicine &Amp; Surgery

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Autologous tooth transplantation is the transplantation of an erupted, partially erupted, or unerupted tooth from one site to another in an individual. This is expected to maintain alveolar bone volume through physiological stimulation of the periodontal ligament (PDL). Tooth transplantation can be used for the closure of oroantral communication. As a simple, useful, and minimally invasive method, it should be considered a surgical option when a donor tooth is available in indicated cases. Herein, the authors report the case of a 20-year-old female patient whose left permanent maxillary first molar had to be extracted due to a longitudinal fracture and radicular cyst in the maxillary sinus floor. After the extraction, tooth 28 was exposed through an osteotomy and positioned in the gap. Nineteen years later, the autologous grafted tooth 28 could no longer be retained due to massive external resorption and was replaced by an implant. Human PDL stem cells can differentiate into bone-, fiber-, and cementum-forming cells and have the potential to build a PDL complex. Therefore, care must be taken to avoid damaging the PDL of the donor tooth during extraction. Autotransplanted teeth are expected to retain the alveolar bone volume. This case demonstrates the use of a transplanted tooth 28 for the treatment of a maxillary defect caused by the extraction of tooth 26 and removal of a radicular cyst. External resorption and regeneration of the bone of the maxillary sinus floor around the transplanted tooth occurred after 19 years.

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Section: Introduction and Importancementioning

confidence: 99%

Bone remodeling of the sinus floor observed 19 years after third molar transplantation to close a maxillary defect: a case report

Grün

Pfaffeneder-Mantai

Bandura

et al. 2023

Annals of Medicine &Amp; Surgery

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Time-course study of genetic changes in periodontal ligament regeneration after tooth replantation in a mouse model

Ohshima,

Abe,

Morita

et al. 2024

Sci Rep

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This research focused on analyzing gene expression changes in the periodontal ligament (PDL) after tooth re-plantation to identify key genes and pathways involved in healing and regeneration. Utilizing a mouse model, mRNA was extracted from the PDL at various intervals post-replantation for RNA sequencing analysis, spanning from 3 to 56 days. The results revealed significant shifts in gene expression, particularly notable on day 28, supported by hierarchical clustering and principal component analysis. Gene ontology (GO) enrichment analysis highlighted an upregulation in olfactory receptor and G protein-coupled receptor signaling pathways at this time point. These findings were validated through reverse transcription-quantitative PCR (RT-qPCR), with immunochemical staining localizing olfactory receptor gene expression to the PDL and surrounding tissues. Moreover, a scratch assay indicated that olfactory receptor genes might facilitate wound healing in human PDL fibroblasts. These results underscore the importance of the 28-day post-transplant phase as a potential “tipping point” in PDL healing and regeneration. In conclusion, this research sheds light on the potential role of olfactory receptor genes in PDL regeneration, providing a foundation for developing new therapeutic approaches in tooth replantation and transplantation, with broader implications for regenerative medicine in oral health.

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Midterm outcomes of autogenous mature third molars transplantation into surgically created sockets: A retrospective cohort study

Ainiwaer,

Gong,

Zuolipahaer

et al. 2024

Dental Traumatology

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Background/AimsThe purpose of this study was to observe the outcome of mature third molars transplantation into surgically created sockets with the assistance of computer designed three dimensional (3‐D) printed replicas and compare its outcome with the conventional fresh socket autotransplantation.Material and MethodsThis study included total of 96 mature third molars autotransplanted in 96 cases with the guidance of computer designed 3‐D printed replicas. Forty‐eight teeth autotransplanted into surgically created sockets were enrolled into the surgically created socket group and 48 teeth conventionally autotransplanted into fresh sockets were enrolled into the fresh socket group. In the surgically created socket group, mature third molars were autotransplanted into surgically prepared sockets at the site of previously missed or extracted molars in the alveolar bone and in the fresh socket group, autotransplantation of mature third molars were performed in fresh sockets of extracted diseased molars simultaneously. After transplantation, the visual analogue scale (VAS) score, Landry Wound Healing Index (LWHI), mobility and probing depth (PD) of the transplanted teeth were measured and the patient satisfaction questionnaire were held in both group. All patients underwent clinical and radiographic examinations during the follow‐up.ResultsDuring the mean follow‐up period of 47.63 ± 16.78 months (range 18–78 months), 92 out of 96 teeth remained in situ without clinical or radiographic complications with overall success rate of 95.83%. No statistically significant differences were found in success and survival rates between the two group. The average extra‐oral time of the donor teeth were 60.76 ± 22.41 s and mean positioning trials of the donor teeth were 2.43 ± 1.19. The VAS score at Day 1 in the surgically created socket group was higher than the fresh socket group (p < .05). LWHI scores in the surgically created group were lower than the fresh socket group during the first 2 weeks (p < .05). The degree of mobility of the transplanted teeth in both group showed no statistically significant difference during the first 3 months. PD in the surgically created group were higher than the fresh socket group in the first month but there were no statistically significant difference after 1 month. Twenty‐six out of 48 cases in the surgically created group needed crown restoration while only 10 cases went through crown restoration in the fresh socket group. Most patients in both group were satisfied with the treatment.ConclusionsAutogenous mature third molars transplantation into surgically created sockets is as effective as conventional fresh socket transplantation. This technique is worth recommending in carefully selected cases and optimistic results can be achieved.

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Tooth transplantation and replantation: Biological insights towards therapeutic improvements

Cited by 4 publications

References 56 publications

Bone remodeling of the sinus floor observed 19 years after third molar transplantation to close a maxillary defect: a case report

Bone remodeling of the sinus floor observed 19 years after third molar transplantation to close a maxillary defect: a case report

Time-course study of genetic changes in periodontal ligament regeneration after tooth replantation in a mouse model

Midterm outcomes of autogenous mature third molars transplantation into surgically created sockets: A retrospective cohort study

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