Tooth survival and periodontal tissues healing of allogenic‐transplanted teeth in the mice

Abstract

Our experimental models using lacZ transgenic ROSA26 mice clearly demonstrate that donor periodontal tissue cells are replaced by host cells and that periodontal tissue can regenerate after allogenic tooth transplantation. Furthermore, our models suggest that donor pulpal cells can survive if the vascular supply into the pulp chamber is sufficient.

Root and periodontal tissue development after allogenic tooth transplantation between rat littermates

“…Allogenically transplanted teeth have been reported to cause irreversible root resorption, followed by the loss of the tooth graft (Nordenram, 1982; Schwartz et al , 1987). Mouse teeth transplanted into tooth sockets allogenically have shown inflammatory pulp tissue and poor arrangement of periodontal ligaments, and the process often results in immune rejection (Kim et al , 2006; Unno et al , 2009). This study reports that about one‐third of allogenically transplantated teeth were either lost or extensively absorbed or suffered from ankylosis of roots, and about 40% of examined transplanted teeth showed degeneration of dental pulp tissue with or without inflamed periodontal ligaments, possibly because of immune rejection (Kim et al , 2006; Unno et al , 2009).…”

“…Mouse teeth transplanted into tooth sockets allogenically have shown inflammatory pulp tissue and poor arrangement of periodontal ligaments, and the process often results in immune rejection (Kim et al , 2006; Unno et al , 2009). This study reports that about one‐third of allogenically transplantated teeth were either lost or extensively absorbed or suffered from ankylosis of roots, and about 40% of examined transplanted teeth showed degeneration of dental pulp tissue with or without inflamed periodontal ligaments, possibly because of immune rejection (Kim et al , 2006; Unno et al , 2009). Further investigation will elucidate how immune response is involved in absorption and/or loss of transplanted teeth as well as the reduction in root numbers and length.…”

“…In contrast, allogenically transplanted teeth have been reported to cause irreversible root resorption, followed by the loss of the tooth graft (Nordenram, 1982; Schwartz et al , 1987). Mouse teeth transplanted into tooth sockets allogenically have shown inflammatory pulp tissue and poor arrangement of periodontal ligaments, and the process often results in immune rejection (Kim et al , 2006; Unno et al , 2009).…”

Effects of Fibrillin Application on Periodontal Ligament Regeneration in Mouse Model of Tooth Replantation

“…However, the conditions of extracted teeth are unique, and PDL cells of extracted teeth become necrotic 24,25) . Our present transplantation experiment using Wnt1-Cre;R26R mice also showed that the PDL tissue contained cells derived from alveolar sockets.…”

Tooth autotransplantations - lessons from animal models: a review

“…The disadvantage is that autotransplantation does not generate a new tooth but just fills in the gap in a more exposed part of the dental arch. To search for other options, stem cellbased tissue engineering (Ohazama et al 2004), allotransplantations or even xenotransplantations have been tested using animal models (Groisman et al 1989;Schwartz et al 1990;Schwartz and Andreasen 2002b;Kim et al 2006;Takamori et al 2008;Mutoh et al 2011;Saito et al, 2011).…”