Tooth shape formation and tooth renewal: evolving with the same signals

Jernvall, Jukka; Thesleff, Irma

doi:10.1242/dev.085084

Cited by 314 publications

(361 citation statements)

References 92 publications

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“…Vertebrates have reduced the number of tooth sets over time with fewer teeth in the mouth at any one time, combined with a loss of tooth replacement capabilities [6]. This appears to correlate with a general shift to complex teeth, indicating a trade off between how many teeth are produced and the level of tooth shape complexity [22].…”

Section: Tooth Replacement: An Ancient Systemmentioning

confidence: 99%

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Evolution and developmental diversity of tooth regeneration

Tucker

Fraser

2014

Seminars in Cell & Developmental Biology

123

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a b s t r a c tThis review considers the diversity observed during both the development and evolution of tooth replacement throughout the vertebrates in a phylogenetic framework from basal extant chondrichthyan fish and more derived teleost fish to mammals. We illustrate the conservation of the tooth regeneration process among vertebrate clades, where tooth regeneration refers to multiple tooth successors formed de novo for each tooth position in the jaws from a common set of retained dental progenitor cells. We discuss the conserved genetic mechanisms that might be modified to promote morphological diversity in replacement dentitions. We review current research and recent progress in this field during the last decade that have promoted our understanding of tooth diversity in an evolutionary developmental context, and show how tooth replacement and dental regeneration have impacted the evolution of the tooth-jaw module in vertebrates.

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Section: Tooth Replacement: An Ancient Systemmentioning

confidence: 99%

“…This reduction in replacement appears correlated with the requirement of complex occlusion for efficient food processing [22,58]. The functional mammalian teeth sit in a socket in the jaw (thecodont attachment), a situation similar to Crocodilians but this appears to be a case of convergent evolution [59].…”

Section: Mammalsmentioning

confidence: 99%

Evolution and developmental diversity of tooth regeneration

Tucker

Fraser

2014

Seminars in Cell & Developmental Biology

123

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“…Vertebrate groups exhibit profound dental morphological variation, making teeth interesting models for the study of evolutionary developmental biology (2). Dental morphology is highly specialized to diet, and prey preference can shift throughout ontogeny.…”

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confidence: 99%

“…Recently there has been a bid to understand such regenerative capabilities in an attempt to develop new clinical applications in humans, which lose the ability to regenerate teeth after two generations (diphyodonty) (6)(7)(8)(9). Additionally, teeth are also useful for the evolutionary developmental study of morphological novelty; dentitions vary substantially in tooth number, shape, and generation rate but form from a highly conserved ancestral developmental framework (2,5). To expand our knowledge of developmental dynamics and the evolution of novelty, we need to extend our research of development to new models exhibiting diverse phenotypes.…”

mentioning

confidence: 99%

Spatially restricted dental regeneration drives pufferfish beak development

Thiery

Shono

Kurokawa

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Vertebrate dentitions are extraordinarily diverse in both morphology and regenerative capacity. The teleost order Tetraodontiformes exhibits an exceptional array of novel dental morphologies, epitomized by constrained beak-like dentitions in several families, i.e., porcupinefishes, three-toothed pufferfishes, ocean sunfishes, and pufferfishes. Modification of tooth replacement within these groups leads to the progressive accumulation of tooth generations, underlying the structure of their beaks. We focus on the dentition of the pufferfish (Tetraodontidae) because of its distinct dental morphology. This complex dentition develops as a result of (i) a reduction in the number of tooth positions from seven to one per quadrant during the transition from first to second tooth generations and (ii) a dramatic shift in tooth morphogenesis following the development of the firstgeneration teeth, leading to the elongation of dental units along the jaw. Gene expression and 1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI) lineage tracing reveal a putative dental epithelial progenitor niche, suggesting a highly conserved mechanism for tooth regeneration despite the development of a unique dentition. MicroCT analysis reveals restricted labial openings in the beak, through which the dental epithelium (lamina) invades the cavity of the highly mineralized beak. Reduction in the number of replacement tooth positions coincides with the development of only four labial openings in the pufferfish beak, restricting connection of the oral epithelium to the dental cavity. Our data suggest the spatial restriction of dental regeneration, coupled with the unique extension of the replacement dental units throughout the jaw, are primary contributors to the evolution and development of this unique beak-like dentition.tooth development | diversity | dental regeneration | stem cells | novelty

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“…In this evolutionary process, mammals have acquired more heterogeneous dentitions, including fewer but more complex teeth 2 . Today, murine rodents, the Old World mice and rats, are one of the most successful living examples of mammalian radiation, which can partly be explained by the evolution of novel dental morphologies contributing to the colonization of numerous environments and habitats.…”

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confidence: 99%

Roles of dental development and adaptation in rodent evolution

et al. 2013

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In paleontology, many changes affecting morphology, such as tooth shape in mammals, are interpreted as ecological adaptations that reflect important selective events. Despite continuing studies, the identification of the genetic bases and key ecological drivers of specific mammalian dental morphologies remains elusive. Here we focus on the genetic and functional bases of stephanodonty, a pattern characterized by longitudinal crests on molars that arose in parallel during the diversification of murine rodents. We find that overexpression of Eda or Edar is sufficient to produce the longitudinal crests defining stephanodonty in transgenic laboratory mice. Whereas our dental microwear analyses show that stephanodonty likely represents an adaptation to highly fibrous diet, the initial and parallel appearance of stephanodonty may have been facilitated by developmental processes, without being necessarily under positive selection. This study demonstrates how combining development and function can help to evaluate adaptive scenarios in the evolution of new morphologies.

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Tooth shape formation and tooth renewal: evolving with the same signals

Cited by 314 publications

References 92 publications

Evolution and developmental diversity of tooth regeneration

Evolution and developmental diversity of tooth regeneration

Spatially restricted dental regeneration drives pufferfish beak development

Roles of dental development and adaptation in rodent evolution

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