Tooth eruption: Theories and facts

Marks, Sandy C.; Schroeder, Hubert E.

doi:10.1002/(sici)1097-0185(199606)245:2<374::aid-ar18>3.0.co;2-m

Cited by 288 publications

(227 citation statements)

References 84 publications

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“…It has also been postulated that remodeling of proteoglycans may contribute to tooth eruption (12,13). The present study found that the expression of ADAMTS5 decreases after 24 h by 2.1 fold, suggesting that iRoot BP may have a negative effect on the remodeling of proteoglycans which constitute the extracellular environment of the teeth.…”

Section: Discussionsupporting

confidence: 51%

Gene expression changes in bioceramic paste-treated human dental pulp cells

Torun

Demirkaya

et al. 2016

J Oral Sci

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Abstract:We evaluated the gene expression profiles of human dental pulp cells exposed to iRoot BP using microarray after 24 and 72 h. The results were verified using quantitative reverse transcriptase PCR analysis. Of the 36,000 transcripts arrayed, 21 were up-regulated and 15 were down-regulated by more than two fold. The largest group of up-regulated genes included those involved in nucleobase-containing compound metabolic processes, cell communication, protein metabolic processes, developmental processes, and biological regulation. The largest groups of down-regulated genes were those involved in cell communication, development, and biological regulation processes. In conclusion, iRoot BP affects the expression of genes involved in different biological processes in human dental pulp cells. (J Oral Sci 58, 307-315, 2016)

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Section: Discussionsupporting

confidence: 51%

Gene expression changes in bioceramic paste-treated human dental pulp cells

Torun

Demirkaya

et al. 2016

J Oral Sci

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“…An increased number of osteoclasts were present, and subsequently, it was demonstrated that canonical Wnt signaling within differentiated osteoblasts induces the expression and secretion of osteoprotegerin (OPG), an important inhibitor of osteoclastogenesis (137). Thus, by stabilizing b-catenin, the OPG:RANKL ratio increased followed by decreased osteoclastogenesis and defective tooth eruption (137,150), which are classical signs of osteopetrosis in murine models (151,152,153,154). Along the same lines, deletion of b-catenin in osteocytes resulted in decreased BMD due to an increased number and activity of osteoclasts (155).…”

Section: Evidence For a Role Of Canonical Wnt Signaling In Bone Resormentioning

confidence: 97%

Genetics in Endocrinology: Autosomal dominant osteopetrosis revisited: lessons from recent studies

Bollerslev

Henriksen

Nielsen

et al. 2013

European Journal of Endocrinology

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Systematic studies of autosomal dominant osteopetrosis (ADO) were followed by the identification of underlying mutations giving unique possibilities to perform translational studies. What was previously designated ADO1 turned out to be a high bone mass phenotype caused by a missense mutation in the first propeller of LRP5, a region of importance for binding inhibitory proteins. Thereby, ADO1 cannot be regarded as a classical form of osteopetrosis but must now be considered a disease of LRP5 activation. ADO (Albers-Schönberg disease, or previously ADO2) is characterized by increased number of osteoclasts and a defect in the chloride transport system (ClC-7) of importance for acidification of the resorption lacuna (a form of Chloride Channel 7 Deficiency Osteopetrosis). Ex vivo studies of osteoclasts from ADO have shown that cells do form normally but have reduced resorption capacity and an expanded life span. Bone formation seems normal despite decreased osteoclast function. Uncoupling of formation from resorption makes ADO of interest for new strategies for treatment of osteoporosis. Recent studies have integrated bone metabolism in whole-body energy homeostasis. Patients with ADO may have decreased insulin levels indicating importance beyond bone metabolism. There seems to be a paradigm shift in the treatment of osteoporosis. Targeting ClC-7 might introduce a new principle of dual action. Drugs affecting ClC-7 could be antiresorptive, still allowing ongoing bone formation. Inversely, drugs affecting the inhibitory site of LRP5 might stimulate bone formation and inhibit resorption. Thereby, these studies have highlighted several intriguing treatment possibilities, employing novel modes of action, which could provide benefits to the treatment of osteoporosis.

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“…Primary teeth will shed (exfoliate) to their permanent successors. Although many theories have been advanced (Marks Jr., 1996;Philbrick et al, 1998;Wise et al, 2002), the factors responsible for the eruption of the teeth are not fully understood. The factors that have been related to the eruption of teeth include elongation of the root, forces exerted by the vascular tissues around and beneath the root, growth of the alveolar bone, growth of dentin, growth and pull of the periodontal membrane, hormonal influences (pituitary growth hormone, thyroid hormone, and parathyroid hormone-related protein), presence of a viable dental follicle, pressure from the muscular action, and resorption of the alveolar crest.…”

Section: Upper Permanent Teeth Development Chart Upper Teethmentioning

confidence: 99%

What is the Role of Pediatricians on Oral Health?

Çubukçu¹

2012

Complementary Pediatrics

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Tooth eruption: Theories and facts

Cited by 288 publications

References 84 publications

Gene expression changes in bioceramic paste-treated human dental pulp cells

Gene expression changes in bioceramic paste-treated human dental pulp cells

Genetics in Endocrinology: Autosomal dominant osteopetrosis revisited: lessons from recent studies

What is the Role of Pediatricians on Oral Health?

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