Tooth eruption and cementum formation in the Runx2/Cbfa1 heterozygous mouse

Zou, Shu Juan; D’Souza, Rena N.; Åhlberg, Tuuli; Bronckers, A.L.J.J.

doi:10.1016/s0003-9969(03)00135-3

Cited by 30 publications

(27 citation statements)

References 17 publications

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“…In experiments on heterozygous RUNX2 knock-out mice, Zou et al [68] did not find any striking differences with regard to eruption of the dentition compared to wild-type mice. They concluded that apparently one healthy allele is sufficient for proper tooth eruption.…”

Section: Diskussionmentioning

confidence: 94%

“…In Experimenten an heterozygoten RUNX2-Knockout-Mäusen fanden Zou et al [68] im Vergleich mit WildtypTieren keinen auffälligen Unterschied bezüglich der Eruption der Dentition und schlossen daraus, dass hier offensichtlich ein gesundes Allel für einen ordnungsgemäßen Zahndurchbruch ausreichend sei. Yoda et al [63] dagegen fanden in ihren Untersuchungen zwar keine Unterschiede bezüglich der Entwicklung der Zähne, aber eine signifikante Verzögerung in der Eruption.…”

Section: Diskussionunclassified

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The Role of Periodontal Ligament Cells in Delayed Tooth Eruption in Patients with Cleidocranial Dysostosis*

et al. 2009

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Section: Diskussionmentioning

confidence: 94%

Section: Diskussionunclassified

The Role of Periodontal Ligament Cells in Delayed Tooth Eruption in Patients with Cleidocranial Dysostosis*

et al. 2009

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“…Structural anomalies of the roots and cementum in particular may also occur [6]. Dental findings made in RUNX2-knockout mice resemble those in humans [1,2,88,92]. The pathogenesis of numerous dental anomalies is still unclear.…”

Section: Funktionen Von Runx2mentioning

confidence: 99%

“…Auch können Strukturanomalien der Wurzeln und insbesondere des Wurzelzements auftreten [6]. Bei RUNX2-Knockout-Mäusen finden sich ähnliche dentale Befunde wie beim Menschen [1,2,88,92]. Die Pathogenese der zahlreichen dentalen Anomalien ist noch unklar.…”

Section: Funktionen Von Runx2unclassified

Die Bedeutung von RUNX2 in der postnatalen Entwicklung des Kondylus

et al. 2010

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We observed that RUNX2 is involved in normal condylar growth in the mouse and probably plays a significant role in osteogenesis and angiogenesis. The RUNX2 also has a biomechanical correlation in relation to cartilage compartmentalization. At the protein level, we noted no differences in the occurrence and distribution of RUNX2 in the condyle, except for a short phase during the 4th and 6th postnatal weeks, so that one allele might suffice for largely normal growth; other biological factors may have compensatory effects. However, we did observe small changes in a few cephalometric parameters concerning the mandibles of heterozygous knockout animals. We discuss potential correlations to our findings by relating them to the most current knowledge about the RUNX2 biology.

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“…Especially the retardation of tooth movement which has been proved to be a consequence of the haplo insufficiency of the Runx2 gene involving transcription factor CBFA1 [26][27][28][29] makes anchorage an even more important issue; unwanted side-effects could be increased as compared to healthy individuals. That is why in tooth traction of CCD patients biomechanical properties of the often individually planned appliances must be thought through very carefully.…”

Section: Introductionmentioning

confidence: 99%

A Simultaneous Mobilization Of Four Impacted Upper Incisors In A Case Of An Adolescent Patient With Cleidocranial Dysplasia (CCD)

Te¹,

Kj²,

Yc³

et al. 2014

Dentistry

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Introduction: Cleidocranial dysplasia (CCD) is often attended by a considerable number of supernumerary teeth combined with impaction of sometimes all permanent teeth. To help these patients obtain an esthetically pleasing and functional dentition, eruption of an appropriate number of permanent teeth should ideally be brought about, while all other teeth should be removed. The simultaneous traction of several neighboring teeth into the same direction is associated with biomechanical challenges. This report illustrates how these difficulties were solved in a specific treatment case.

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Tooth eruption and cementum formation in the Runx2/Cbfa1 heterozygous mouse

Cited by 30 publications

References 17 publications

The Role of Periodontal Ligament Cells in Delayed Tooth Eruption in Patients with Cleidocranial Dysostosis*

The Role of Periodontal Ligament Cells in Delayed Tooth Eruption in Patients with Cleidocranial Dysostosis*

Die Bedeutung von RUNX2 in der postnatalen Entwicklung des Kondylus

A Simultaneous Mobilization Of Four Impacted Upper Incisors In A Case Of An Adolescent Patient With Cleidocranial Dysplasia (CCD)

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