Abstract:We report that the dynamics of antibiotic capture and transport across a
voltage-biased OmpF nanopore is dominated by the electroosmotic flow rather than the
electrophoretic force. By reconstituting an OmpF porin in an artificial lipid bilayer and
applying an electric field across, we are able to elucidate the permeation of
molecules, and their mechanism of transport. This field gives rise to an
electrophoretic force acting directly on a charged substrate, but also
indirectly via coupling to all other mobile i… Show more
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