“…9 Third, Ang-(1-7) directly activates nitric oxide (NO) synthase, stimulating production of NO, another potent vasodilator. 12 Fourth, it impairs ACE-dependent hydrolysis of bradykinin into bradykinin-(1-7) and bradykinin-(1-5), which leads to excessive accumulation of bradykinin (Figure 1). 13 www.anesthesia-analgesia.org…”