Tools for Assessing Outcomes in Studies of Chronic Cough

Boulet, Louis‐Philippe; Coeytaux, Remy R; McCrory, Douglas C; French, Cynthia T.; Chang, Anne B.; Birring, Surinder S.; Smith, Jaclyn A.; Diekemper, Rebecca L.; Rubin, Bruce K.; Irwin, Richard S.

doi:10.1378/chest.14-2506

Cited by 102 publications

(91 citation statements)

References 101 publications

(11 reference statements)

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“…All these instruments have been developed for chronic cough in a general population and are reviewed elsewhere [55]. Experience and validation of these tools in patients with IPF are limited (table 2 provides an overview).…”

Section: Assessment Of Cough In Ipfmentioning

confidence: 99%

Cough in idiopathic pulmonary fibrosis

et al. 2016

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Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is most probably "multifactorial" and influenced by mechanical, biochemical and neurosensory changes, with an important role for comorbidities as well. Clinical trials of cough treatment in IPF are emerging, and cough is increasingly included as a secondary end-point in trials assessing new compounds for IPF. It is important that such studies include adequate end-points to assess cough both objectively and subjectively. This article summarises the latest insights into chronic cough in IPF. It describes the different theories regarding the pathophysiology of cough, reviews the different methods to assess cough and deals with recent and future developments in the treatment of cough in IPF. @ERSpublications Latest insights into pathophysiology of cough, methods to assess cough and developments in treatment of cough in IPF http://ow.ly/YfVAH

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Section: Assessment Of Cough In Ipfmentioning

confidence: 99%

Cough in idiopathic pulmonary fibrosis

et al. 2016

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“…Numerous studies were performed to define clinical tools for measurement of cough. Among them, there are cough monitors, cough specific quality of life questionnaires, VAS and sensitivity to inhaled cough irritants measured in cough challenge test [9,10]. To follow the effect of speech therapy in our patient, we used the above mentioned tools with the exception of cough monitor.…”

Section: Discussionmentioning

confidence: 99%

“…Before initiation of speech therapy, cough severity and its influence on quality of life was assessed in accordance with ERS guidelines [9]. We applied Visual Analogue Scale (VAS) for subjective assessment of cough severity and Leicester Cough Questionnaire (LCQ) for evaluation of influence of cough on patients' quality of life [9,10]. Moreover, cough challenge test with capsaicin was performed to assess the sensitivity to inhaled irritants [9,10].…”

Section: Case Reportmentioning

confidence: 99%

Speech Therapy—A Non-Pharmacological Method to Manage Difficult-to-treat Chronic Cough

Krakowiak

Dąbrowska

Buła

et al. 2017

Advances in Respiratory Medicine

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Cough is the most common symptom of respiratory diseases. The results of management of chronic cough in adults are still unsatisfactory. Unexplained and difficult-to-treat chronic cough causes significant impairment in patients' quality of life. The results of recent studies suggest that speech therapy (speech language intervention) is one of the few methods which are usefull in management of persistent chronic cough. We present a case of a patient with chronic cough due to chronic nonallergic rhinitis and gastroesophageal reflux disease, who had been unsuccessfully treated for 18 years. In the patient speech therapy resulted in a significant decrease of cough severity and improvement of quality of life.

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“…We established a strong correlation among the domains of the questionnaire, but a weak correlation between the LCQ and cough VAS. The other studies demonstrated that correlation with cough specific VAS varied widely from study to study, but showed robust results [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…Responsiveness was analysed by calculating the 95% confidence interval for the average improvements in the three domain scores and the total score of the LCQ. [7][8][9][10][11][12][13][14][15][16].…”

Section: Validationmentioning

confidence: 99%

Reliability and Validity of a Lithuanian version of Leicester Cough Questionnaire

Merkyte¹,

Biekšienė²,

Vaguliene³

et al. 2016

JLPRR

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Background: Cough is the most common presenting symptom in primary practice.[1] Chronic, exhausted cough has a significant impact on the quality of life [2]. Cough questionnaire was developed to evaluate the quality of life for patients with chronic cough. Unfortunatelly, such kind of health status measurement do not exist in Lithuania yet. Methods:The translation of Leicester Cough Questionnaire (LCQ) was made using all methods that are required, following a forward-backward translation procedure. The Questionnaire and Visaul Analogue Scale (VAS) was completed by 53 patients with chronic cough (duration of cough > 8 weeks).The Questionnaire was divided into three domains: physical, psychological and social. To validate LCQ we tested three different aspects, i.e. the concurrent validity, the internal consistency and the repeatability.Results: A strong correlation was established among the domains of the questionnaire and a statistically significant correlation established between the questionnaire and VAS. Cronbach`s alpha coefficients for the internal consistency were from 0,787 to 0,927. The intraclass correlation coefficient (ICC) of the testretest reliability was 0,89 (p<0,0001). Conclusion:The Lithuanian version of Leicester Cough Questionnaire is ready, compatible with original and understandable for patients. Leicester Cough Questionnaire appears to be valid, reliable and highly responsive. BackgroundCough is one of the most common causes of presentation to general practice. Cough that has been persisted longer than three weeks is subacute (three to eight weeks) or chronic (more than eight weeks) About 15 precentages of non smoking people complain about the chronic cough [1].Chronic cough is the most common complain during the visit to a pulmonologist. Cough is described as a protective reflex that removes excessive secretions and inhaled foreign bodies from the respiratory tract. The anatomy of respiratory tract which is plentiful of cough receptors is the reason, that the most frequently causes of chronic cough are upper airway disorders, asthma and gastroesophageal reflux. There is some controversy if these conditions are aggravants or causes of cough. What is more, many people have a cough reflex sensitivity and their cough cannot be expalined [2,3].Patients with chronic cough suffer physical and psychological morbidity. Long lasting chronic cough can affect the quality of life interfering with physical symptoms as chest pain, syncope, incontinence, sore throat and headaches. What is more, people are more depressed, feel anxienty or social embarrassment of their cough. It can dissturb not only work and activity but also family members and friends [2-6].To effectively evaluate the impact of chronic cough on quality of life, it is important to have valid measurement tools. A number of measurment tools including questionnaires, cough diaries, visual analogue scales, electronic recordings, and human counts are available to assess the impact of quality of life for people with chronic cough. However...

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Tools for Assessing Outcomes in Studies of Chronic Cough

Cited by 102 publications

References 101 publications

Cough in idiopathic pulmonary fibrosis

Cough in idiopathic pulmonary fibrosis

Speech Therapy—A Non-Pharmacological Method to Manage Difficult-to-treat Chronic Cough

Reliability and Validity of a Lithuanian version of Leicester Cough Questionnaire

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