Toolbox study for application of hydrogen peroxide as a versatile, safe and industrially-relevant green oxidant in continuous flow mode

Abstract

Hydrogen peroxide is showcased in a range of oxidations, operating in continuous-flow equipment to deliver practical and risk-minimized procedures.

Green Organocatalytic Oxidative Methods using Activated Ketones

“…We have so far provided a variety of oxidation methods involving the use of 2,2,2‐trifluoromethylacetophenone as the catalyst activator and H 2 O 2 as the oxidant. Efforts in further developing H 2 O 2 as an oxidant are continuous, and chemical industries are highly interested in this . However, to provide a protocol that will be easily adopted by industry and academia an asymmetric variant has to be developed.…”

“…Efforts in further developing H 2 O 2 as an oxidant are continuous, and chemical industries are highly interested in this. [139] However,t op rovide ap rotocol that will be easily adopted by industry and academia an asymmetric variant has to be developed. Future efforts should targett he identification of an appropriate chiral activated ketonet hat will asymmetrically mediate these oxidations.…”

The Metal Type Governs Photocatalytic Reactive Oxygen Species Formation by Semiconductor‐Metal Hybrid Nanoparticles

“…This functionality was already utilized in various applications including photopolymerization toward 3D printing of hydrogels in water, photodynamic therapy, and anti‐bacterial activity . The generated ROS can also be harnessed for additional environmental and chemical applications such as wastewater treatment and green chemistry . It is therefore highly important to study the influence of various metal co‐catalysts on molecular oxygen reduction and therefore the ROS formation by HNPs as photocatalysts.…”

Sulfonylation of Benzylic C−H Bonds through the Reaction of Aryl(o‐tolyl)methanones with Sulfonyl Hydrazides or Sulfonyl Chlorides

“…[2] Thus, significante ffort has been devoted to the construction of sulfone compounds. Traditionally,s ulfone derivatives were synthesized throught he nucleophilic substitution of carbon electrophiles with thiols [3] or disulfides [4] and subsequento xidation. However,t his method was limited, owing to the unpleasant smell of thiols and the incompatibility of sensitive functional groups under oxidative conditions.…”