Too many women are dying from cervix cancer: Problems and solutions

Gaffney, David K.; Hashibe, Mia; Kepka, Deanna; Maurer, Kathryn A.; Werner, Theresa L.

doi:10.1016/j.ygyno.2018.10.004

Cited by 77 publications

(50 citation statements)

References 74 publications

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“…The focus should be directed toward healthcare workers who have concerns about HPV vaccine safety [ 82 ]. It has been reported that more than half a million new cases of cervical cancer are diagnosed annually with high mortality rates registered in poor countries [ 83 , 84 ].…”

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of global scientific literature on vaccine hesitancy in peer-reviewed journals (1990–2019)

Sweileh

2020

BMC Public Health

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Background Vaccine hesitancy is a growing threat to national and global health security. The current study was undertaken to provide insights into the global scientific literature on vaccine hesitancy in peer-reviewed journals. Method The current study was a descriptive bibliometric study. A validated search strategy on vaccine hesitancy was implemented using SciVerse Scopus. Bibliometric indicators such as (1) annual growth of publications, (2) key players, (3) research themes, (4) pathogens/diseases encountered, (5) top-cited documents, and (6) annual growth of publications stratified by world region and by age category were presented. The study period was from 1990 to 2019. Results Search strategy found 2791 documents. The h -index of the retrieved literature was 89. The leading journal was Vaccine (369; 13.2%%) followed by Human Vaccines and Immunotherapeutics (129; 4.6%). Authors from the USA led with 1125 (40.3%) followed by authors from Italy (234; 8.4%) and the UK (204; 7.3%). The US CDC led with 140 (5.0%) documents followed by Emory University (USA) (81, 2.9%). The list of active authors included six from the USA while the remaining were from France, Australia, and Canada. Research themes in the retrieved literature focused on influenza, human papillomavirus, and the role of parents in immunization of their children. The region of the Americas and the European region had the greatest share of publications and showed steep growth of publications lately. Vaccine hesitancy research on adolescents was most noticed after 2007 while that on children was present all the time but escalated lately. Titles/abstracts analysis indicated that 621(22.3%) documents focused on influenza, 392 (14.0%) focused on Human papillomavirus, and 292 (10.5%) focused on measles. The top-cited documents in literature published after 2015 focused on the definition and strategies to overcome vaccine hesitancy. Conclusion The last decade witnessed a noticeable increase in the number of publications. Influenza vaccine and parental concerns about the human papillomavirus vaccine were the main focus of the retrieved literature. Information on vaccine hesitancy needs to be collected from all countries to build a better coalition against the anti-vaccination groups. Re-building trust in vaccines requires targeting parents by providing adequate information on the vaccines.

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Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of global scientific literature on vaccine hesitancy in peer-reviewed journals (1990–2019)

Sweileh

2020

BMC Public Health

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“…[11][12][13][14] Screening policies should take into consideration socio-economic factors, which influence disease causation. 15 The introduction of innovative methods for screening of large population should be emphasized. Public awareness on early detection by screening should be encouraged.…”

Section: Discussionmentioning

confidence: 99%

Screening for non-communicable diseases

Christe

Vijaya²,

Tharangini³

2020

Int J Reprod Contracept Obstet Gynecol

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Background: This study was conducted to enumerate the results of screening for non-communicable diseases in the NCD clinic over a period of one year in a tertiary health centre.Methods: The results from screening tests conducted in the NCD clinic, for detecting hypertension, diabetes mellitus, breast cancer and cervical cancer, in Government tertiary care Hospital for Women, Chennai, were recorded. The flowchart and screening methods followed were those recommended by the NHM - NPCDCS. Data thus obtained was analyzed using standard statistical methods.Results: Of 42,519 women screened for common non communicable diseases - hypertension, diabetes mellitus, breast cancer and cervical cancer, nearly 5.55% women (n = 2359) had positive results, for any one of the diseases screened. Of 11,708 women screened for diabetes mellitus and 13,971 screened for hypertension, positive results were found in 856 women and 1,216 women respectively. Around 7,568 women were screened for cervical cancer and 175 women tested positive. A large number of 9,272 women were screened for breast cancer and 112 women had positive results. As per the guidelines, women who tested positive for screening tests were referred to the concerned departments in RGGGH.Conclusions: Nearly 42,519 women were screened for common non-communicable diseases (NCDs) - hypertension, diabetes mellitus, breast cancer and cervical cancer, and 5.55% women had positive test results for any one of the diseases screened. The screening revealed, 8.7% of women had raised blood pressure, 7.31% had raised blood sugar levels, 1.21% women had positive screening test results for breast cancer, and 2.31% women for cervical cancer.

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“…Especially in Eastern Africa, cervical cancer was the most frequently diagnosed cancer in women. There were many risk factors that influence cause of cervical cancer, such as high-risk human papillomavirus(hrHPV) infection, smoking, health conditions, economic status and sexual partners (2,3). Compared with 2012 statistics, the incidence of cervical cancer in 2015 had decreased by 1.3% (4), possibly dued to production of HPV vaccine, improvement of living conditions and early screening (5).…”

Section: Introductionmentioning

confidence: 99%

Identification of prognosis-related genes in the cervical cancer immune microenvironment

Yang

Meng

et al. 2021

Gene

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Background Cervical cancer is the fourth most common cancer in women worldwide. The metastasis and invasion of this type of cancer are closely related to the tumor microenvironment. Immune cells and stromal cells dominate the tumor microenvironment in cervical cancer. Therefore, we should further understand the association between tumor progress and immune cells or stromal cells. Methods we downloaded the gene expression profiles and clinical data of 307 patients with cervical cancers based on the TCGA database. Subsequently the Estimation of Stromal and Immune cells in Malignant Tumours using Expression data (ESTIMATE) algorithm was used to calculate the scores of stromal cells and immune cells to find differential genes, and analyzed the correlation between their scores and patient survival. Moreover, we also used R language packs and network tools to analyze GO term, gene enrichment pathway, and protein-protein relationship to find genes related to inflammation and immune regulation. Results The gene expression profiles and corresponding clinical data of 307 patients were obtained from TCGA datasets. The results showed that there was a statistically significant difference between the high immunescore group and the low immunescore group. And the low immunescore group had shorter lifetimes than the high scores group (P = 0.035).Moreover, PPI network analysis CCR5 and CXCL9,-10,-11 / CXCR3 axis might be new target for cervical cancer treatment. Finally, Kaplan-Meier survival curves found out nine representative genes significantly related to survival including BTNL8 ,

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Too many women are dying from cervix cancer: Problems and solutions

Cited by 77 publications

References 74 publications

Bibliometric analysis of global scientific literature on vaccine hesitancy in peer-reviewed journals (1990–2019)

Bibliometric analysis of global scientific literature on vaccine hesitancy in peer-reviewed journals (1990–2019)

Screening for non-communicable diseases

Identification of prognosis-related genes in the cervical cancer immune microenvironment

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