Too Little Sleep Gradually Desensitizes the Serotonin 1A Receptor System

Román, Viktor; Walstra, I.; Luiten, P.G.M.; Meerlo, Peter

doi:10.1093/sleep/28.12.1505

Cited by 36 publications

(7 citation statements)

References 28 publications

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“…Neuroimaging studies in adolescents have linked short and disrupted sleep to abnormalities in brain structures involved in emotional control and aggression, including the DMN, the salience network and the PFC (Strenziok et al, 2011; Sung et al, 2020; Tashjian et al, 2018). Additionally, poor sleep has been associated with neurobiological abnormalities involving genes, the hypothalamic pituitary axis (HPA), and serotonin, which may increase aggression (Madrid-Valero et al, 2019; Meerlo et al, 2008; Roman et al, 2005). This experimental evidence, coupled with observations of reduced aggression following sleep treatment, suggest that poor sleep may reversibly cause aggression (Haynes et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Experimental and neuroimaging studies have found that poor sleep alters affect and arousal (Meerlo et al, 2008). For example, chronic partial sleep deprivation has resulted in reduced serotonin receptor sensitivity in rats, a common finding in depression (Roman et al, 2005). Additionally, sleep disruption and deprivation are associated with altered regulation of the HPA, therefore increasing arousal (Meerlo et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

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Exploring the relationship between sleep and aggression in adolescents: A cross sectional study using the UK Millennium cohort study

McCaffrey,

McClure,

Singh

et al. 2024

Clin Child Psychol Psychiatry

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This study aimed to establish if a significant relationship exists between sleep and aggression in a large representative adolescent cohort and explores the impact of potential confounders. This cross-sectional secondary data analysis included 10,866 males and females aged 13–15 years, from the UK-based 2015 Millenium Cohort Study (sixth sweep). Independent variables included self-report measures of sleep duration and quality. The parent reported ‘Strengths and Difficulties Questionnaire’ conduct score measured aggression. Binary logistic regression examined independent associations between each sleep variable and aggression. Multiple regression models then adjusted for potential confounders: age, sex, socioeconomic status, arousal, and affect. Under 8 hours of sleep on average was significantly associated with aggression when age, sex and income were controlled ( p = .008). This became insignificant following adjustment for both affect and arousal. Sleep quality remained significantly associated with aggression when all confounders were controlled: ‘sleep onset latency >30 minutes’ and ‘wakening at least a good bit of the time’ increased the odds of aggression by around 27.9% ( p < .001) and 43.5% respectively ( p < .001). A significant association exists between poor subjective sleep quality and heightened aggression in this cohort, when all our confounders are controlled, identifying sleep quality as a potential target in treating adolescent aggression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exploring the relationship between sleep and aggression in adolescents: A cross sectional study using the UK Millennium cohort study

McCaffrey,

McClure,

Singh

et al. 2024

Clin Child Psychol Psychiatry

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“…HTR1F and KCNJ3 are linked to the serotonergic pathway and are targets of approved ADHD and antiarrhythmic drugs Atomoxetine and Dronedarone, respectively. This is potentially relevant given that serotonin may impact blood pressure regulation, and serotonin receptor desensitization is implicated in chronic sleep restriction 54,55 . HTR1F encodes for 5-HT 1F , shown to function in smooth muscle and trigeminal nerves, with its selective agonists (i.e.…”

Section: Discussionmentioning

confidence: 99%

A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations

Nagarajan,

Winkler,

Bentley

et al. 2024

Preprint

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Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to genes involved in neurological, thyroidal, bone metabolism, and hematopoietic pathways. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausibility of distinct influences of both sleep duration extremes in cardiovascular health. With several of our loci reflecting specificity towards population background or sex, our discovery sheds light on the importance of embracing granularity when addressing heterogeneity entangled in gene-environment interactions, and in therapeutic design approaches for blood pressure management.

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“…Numerous meta-analyses have shown that individuals with insomnia symptoms are more likely to suffer depression than those without sleep problems, and insomnia could largely predict the onset and development of depression [ 11 , 12 ]. Interestingly, Roman et al found that sleep disturbances could gradually attenuate the sensitivity of serotonergic receptor, which is associated with the reduction of cognitive function and an increased risk of depression [ 13 ]. Although the complex bidirectional relationship between sleep disturbances and development of depression has been confirmed, the exploration of the underlying biological mechanisms of the co-occurrence of sleep disorders and depression is still limited.…”

Section: Introductionmentioning

confidence: 99%

A genome-wide association study identifies candidate genes for sleep disturbances in depressed individuals

Yang,

Cheng,

Cheng

et al. 2024

Hum Genomics

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Objective This study aimed to identify candidate loci and genes related to sleep disturbances in depressed individuals and clarify the co-occurrence of sleep disturbances and depression from the genetic perspective. Methods The study subjects (including 58,256 self-reported depressed individuals and 6,576 participants with PHQ-9 score ≥ 10, respectively) were collected from the UK Biobank, which were determined based on the Patient Health Questionnaire (PHQ-9) and self-reported depression status, respectively. Sleep related traits included chronotype, insomnia, snoring and daytime dozing. Genome-wide association studies (GWASs) of sleep related traits in depressed individuals were conducted by PLINK 2.0 adjusting age, sex, Townsend deprivation index and 10 principal components as covariates. The CAUSALdb database was used to explore the mental traits associated with the candidate genes identified by the GWAS. Results GWAS detected 15 loci significantly associated with chronotype in the subjects with self-reported depression, such as rs12736689 at RNASEL (P = 1.00 × 10− 09), rs509476 at RGS16 (P = 1.58 × 10− 09) and rs1006751 at RFX4 (P = 1.54 × 10− 08). 9 candidate loci were identified in the subjects with PHQ-9 ≥ 10, of which 2 loci were associated with insomnia such as rs115379847 at EVC2 (P = 3.50 × 10− 08), and 7 loci were associated with daytime dozing, such as rs140876133 at SMYD3 (P = 3.88 × 10− 08) and rs139156969 at ROBO2 (P = 3.58 × 10− 08). Multiple identified genes, such as RNASEL, RGS16, RFX4 and ROBO2 were reported to be associated with chronotype, depression or cognition in previous studies. Conclusion Our study identified several candidate genes related to sleep disturbances in depressed individuals, which provided new clues for understanding the biological mechanism underlying the co-occurrence of depression and sleep disorders.

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Too Little Sleep Gradually Desensitizes the Serotonin 1A Receptor System

Cited by 36 publications

References 28 publications

Exploring the relationship between sleep and aggression in adolescents: A cross sectional study using the UK Millennium cohort study

Exploring the relationship between sleep and aggression in adolescents: A cross sectional study using the UK Millennium cohort study

A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations

A genome-wide association study identifies candidate genes for sleep disturbances in depressed individuals

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