Tonsillectomy Does Not Reduce Upper Respiratory Infections: A National Cohort Study

Lim

et al. 2018

Sci Rep

Self Cite

The purpose of this study is to evaluate the associations between gastroesophageal reflux disease (GERD) and depression using a national sample cohort of the Korean population. Data were collected from individuals ≥20 years old in the Korean National Health Insurance Service-National Sample Cohort between 2002 and 2013. We designed two different nested case-control studies. In study I, 60,957 participants with depression were matched at a 1:4 ratio with 243,828 controls, and their previous histories of GERD were analyzed. In study II, 133,089 participants with GERD were matched at a 1:2 ratio with 266,178 controls, and their previous histories of depression were analyzed. Crude and adjusted odds ratios (ORs) were analyzed using unconditional logistic regression analyses, and 95% confidence intervals (CIs) were calculated. Subgroup analyses were performed according to age and sex. The adjusted OR for GERD was 2.01 (95% CI = 1.96–2.07) in the patients with depression (study I). The adjusted OR for depression was 1.48 (95% CI = 1.43–1.52) in the patients with GERD (study II). The results of the subgroup analyses were consistent. GERD and depression displayed bidirectional associations.

“…The advantages of this study are similar to those of our previous studies using the national sample cohort 31 – 33 . We used a large, representative nationwide population.…”

Section: Discussionsupporting

confidence: 70%

Bidirectional association between gastroesophageal reflux disease and depression: Two different nested case-control studies using a national sample cohort

Lim

et al. 2018

Sci Rep

Self Cite

“…The strength of this study is the use of a large, representative, nationwide population sample, which is consistent with our previous studies . Because NHIS data include all citizens of the nation without exception, no participants were missing during the follow‐up period.…”

Section: Discussionsupporting

confidence: 55%

Gastroesophageal reflux disease increases the risk of chronic rhinosinusitis: a nested case‐control study using a national sample cohort

Int Forum Allergy Rhinol

Park

Lim

et al. 2018

Self Cite

Background:The purpose of this study was to evaluate the relations between gastroesophageal reflux disease (GERD) and chronic rhinosinusitus (CRS) in a Korean population.Methods: Subjects from the Korean National Health Insurance Service-National Sample Cohort, all ࣙ20 years old, were assessed from 2002 to 2013. In total, 23,489 CRS participants were matched with 93,956 controls at a ratio of 1:4 with respect to age, group, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed previous history of GERD in the CRS and control groups. The CRS group included patients identified using International Classification of Diseases 10th edition (ICD-10) codes (J32) who had treated their CRS ࣙ2 times and had undergone head and neck computed tomography (CT). The GERD group included patients identified using the ICD-10 (K21) code who had treated their GERD ࣙ2 times and had taken a proton pump inhibitor (PPI) for ࣙ2 weeks. Crude and adjusted odds ratios (ORs) were analyzed using unconditional logistic regression analyses. The 95% confidence intervals (CIs) were calculated. Subgroup analyses were performed according to age and sex. Results:The rate of GERD was higher in the CRS group (17.1% [4020 of 23,489]) than in the control group (9.1% [8522 of 93,956]; p < 0.001). The adjusted OR of GERD was 2.04 (95% CI, 1.96-2.13; p < 0.001) in the CRS group. The results of the subgroup analyses were consistent. Conclusion:The ORs of GERD were increased in CRS participants. This relationship was consistent in all age and sex groups. C 2018 ARS-AAOA, LLC.

“…Therefore, to date, it is unclear whether the removal of tonsils and adenoid tissues has a preventive effect on the incidence of URI. Moreover, numerous studies have showed a lack of a preventive effect of adenoidectomy or tonsillectomy on the number of postoperative visits for URIs [ 14 , 15 , 30 , 31 ]. Similar to those studies, we found no difference between the adenotonsillectomy and control groups during the 1- to 11-year post-operative follow-up visits.…”

Section: Discussionmentioning

confidence: 99%

Association of adenotonsillectomy with asthma and upper respiratory infection: A nationwide cohort study

Park

et al. 2020

PLoS ONE

Adenotonsillectomy is a common paediatric surgery for treating obstructed breathing or recurrent inflammation; however, the long-term health consequences on the developing immune system are unknown. This study investigated the potential association between adenotonsillectomy and the development of asthma and upper respiratory infections (URI). This propensity score-matched retrospective cohort study utilized data from the National Sample Cohort 2002–2013. In the asthma cohort, we used a Cox-proportional hazards model to analyze the hazard ratio (HR) of adenotonsillectomy for asthma events. In the URI cohort, equivalence testing of postoperative visits for URI was performed. The margin of equivalence of the difference was set at -0.5–0.5. Asthma incidence was 66.97/1000 person-years in children who underwent adenotonsillectomy and 30.43/1000 person-years in those who did not. Adjusted asthma HRs were 2.25 (95% confidence interval, 1.96–2.57) in the adenotonsillectomy vs. non-adenotonsillectomy groups. In a subgroup analysis, children aged 5–9 years living in metropolitan areas showed a higher incidence of subsequent asthma than those of other ages and areas. However, any significant difference between the groups in terms of URI events in the 1–11-year postoperative period was not identified. Adenotonsillectomy in children is associated with an increased incidence of asthma, with no significant impact on postoperative visits for URI.