Tonsillectomy and steroid pulse therapy significantly impact on clinical remission in patients with IgA nephropathy

A case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome complicated by IgA nephropathy with nephrotic syndrome

“…A search of the literature using the PubMed system turned up only six reported cases of IgAN complicated with skin or bone disease, excluding the present case (Table 2) [16][17][18][19][20]. As pointed out by the authors of those studies, palmoplantar pustulosis and sternocostoclavicular hyperostosis, as well as IgAN, are associated with tonsillar infections, and tonsillectomies are an effective treatment of those diseases [21][22][23][24]. That suggests activation/dysfunction of the immune response to tonsillar infection may be an important etiology for those ailments.…”

Efficacy of Tonsillectomy Plus Methylprednisolone Pulse Therapy for a Child with Henoch-Schoenlein Purpura Nephritis

“…Recently, there have been reports on the efficacy of tonsillectomy for IgAN in adults (Sanai and Kudoh 1996;Hotta et al 2001;Xie et al 2003). Hotta et al reported that tonsillectomy plus methylprednisolone pulse therapy led to clinical remission in adult patients with IgAN (Hotta et al 2001).…”

“…Hotta et al reported that tonsillectomy plus methylprednisolone pulse therapy led to clinical remission in adult patients with IgAN (Hotta et al 2001). In addition, we reported that tonsillectomy pulse therapy was effective for severe IgAN in childhood (Kawasaki et al 2006).…”

“…Frequent association between upper respiratory tract infection and the development of HSP has also been suggested (Yoshikawa et al 1987;Habib et al 1994;Rai et al 1999). Recently, there have been reports of the efficacy of tonsillectomy and tonsillectomy plus methylprednisolone pulse therapy (tonsillectomy pulse therapy) in treating IgAN (Sanai and Kudoh 1996;Hotta et al 2001;Xie et al 2003). In addition, there had been a few reports on the efficacy of tonsillectomy pulse therapy for HSPN in adult (Sugiyama et al 2005).…”

Prominent IgM Deposition in Glomerulus Is Associated with Severe Proteinuria and Reduced after Combined Treatment of Tonsillectomy with Steroid Pulse Therapy in Patients with IgA Nephropathy

“…Proteinuria is a serious risk factor of disease progression in IgAN patients 9 . While two general approaches have been developed to slow such progression -namely blood pressure control using angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and therapy with glucocorticoids 10 -combined treatment of tonsillectomy with steroid pulse therapy Tx-SP has been reported to induce clinical remission of IgAN, representing a more promising, proactive therapy 11 .…”