Tonsillar haemorrhage and measles

John, D. G.; Thomas, P.; Semeraro, D

doi:10.1017/s0022215100104001

Cited by 16 publications

(12 citation statements)

References 2 publications

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“…The pathology associated with the spread of uninfected and infected immune cells into tonsillar epithelium may be responsible for the 'spots' on the surface of the tonsil that have been reported during the prodromal stage of measles (Herrman, 1915). In more serious cases, alterations to the tonsillar epithelium have been associated with rupture and haemorrhaging during the prodromal stage (John et al, 1988;Redman & Chaney, 1959).…”

Section: Discussionmentioning

confidence: 99%

Infection of lymphoid tissues in the macaque upper respiratory tract contributes to the emergence of transmissible measles virus

Ludlow

Vries

Lemon

et al. 2013

Journal of General Virology

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Measles virus (MV), a member of the family Paramyxoviridae, remains a major cause of morbidity and mortality in the developing world. MV is spread by aerosols but the mechanism(s) responsible for the high transmissibility of MV are largely unknown. We previously infected macaques with enhanced green fluorescent protein-expressing recombinant MV and euthanized them at a range of time points. In this study a comprehensive pathological analysis has been performed of tissues from the respiratory tract around the peak of virus replication. Isolation of virus from nose and throat swab samples showed that high levels of both cell-associated and cell-free virus were present in the upper respiratory tract. Analysis of tissue sections from lung and primary bronchus revealed localized infection of epithelial cells, concomitant infiltration of MV-infected immune cells into the epithelium and localized shedding of cells or cell debris into the lumen. While high numbers of MV-infected cells were present in the tongue, these were largely encapsulated by intact keratinocyte cell layers that likely limit virus transmission. In contrast, the integrity of tonsillar and adenoidal epithelia was disrupted with high numbers of MV-infected epithelial cells and infiltrating immune cells present throughout epithelial cell layers. Disruption was associated with large numbers of MV-infected cells or cell debris 'spilling' from epithelia into the respiratory tract. The coughing and sneezing response induced by disruption of the ciliated epithelium, leading to the expulsion of MV-infected cells, cell debris and cell-free virus, contributes to the highly infectious nature of MV.

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Section: Discussionmentioning

confidence: 99%

Infection of lymphoid tissues in the macaque upper respiratory tract contributes to the emergence of transmissible measles virus

Ludlow

Vries

Lemon

et al. 2013

Journal of General Virology

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“…In cases of suspected malignoma, the indication is not under discussion and clear [547] (grade B), [548], [549] (grade C).…”

Section: Resultsmentioning

confidence: 99%

Indications for tonsillectomy stratified by the level of evidence

Windfuhr

2016

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 15:Doc09

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“…β-haemolytic streptococcus, staphylococcus and actinomyces infections have been shown to be the cause of spontaneous tonsillar haemorrhage [3][4][5][6][7][8][9]. Moreover, spontaneous tonsillar bleeding is described as a complication of infectious mononucleosis and measles [10]. Spontaneous tonsillar haemorrhage of non-iatrogenic origin is rare in the literature.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Intracapsular Tonsillar Hemorrhage

Beriat¹

2012

Ann Clin Anal Med

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ÖzetBu vaka sunumunda sol tonsilla palatina medialine yerleşen ve bir kök ile tonsil dokusuna tutunan bir tümör görünümünde olan spontan intakapsüler tonsiller kanama vakasını tartıştık. Hasta 30 yaşında sağlıklı bir gebe kadındı. Hastanın son üç aydır giderek artan orofarenksde yabancı cisim hissi ve yutma güçlüğü mevcuttu. Hastanın akut, kronik tonsillit veya travma öyküsü yoktu. Muayenesinde sol palatin tonsil üst kutbundan küçük bir kök ile ayrılan 2 cm çapında, hareketli kahverengi kitle görüldü. Diğer laboratuar sonuçları normaldi. Kitle genel anestezi altında eksize edildi. Histolojik değerlendirme sonucu kapsül ile çevrelenmiş, lenfoepitelyal doku ve akut kanama alanları olan tonsiler intrakapsüler hemoraji olduğu sonucuna varıldı. Hastamıza doğum sonrası tonsillektomi planlandı. Bu tanı ile izlenen hastalara disfaji, kanama, aspirasyon, riski ve olası malign tümörlerden ayırt etmek amacı ile tonsillektomi yapılmalıdır. AbstractIn this case report, we discussed a case of spontaneous intracapsular tonsillar haemorrhage appearing as a tumor medial to the left palatine tonsil and clinging to the tonsillar tissue with a pedicle. The patient was a 30 years old healthy pregnant woman. She had a growing sensation of a lump in her oropharynx and dysphagia in the past three months. She had no history of acute and chronic tonsillitis or trauma. On examination, a mobile brown mass with a 2 cm diameter having a small pedicle at the upper pole of the left palatine tonsil was seen. Other laboratory results were normal. The mass was excised under general anesthesia. Histological evaluation revealed tonsillar intracapsular bleeding with lymphoepithelial tissue and acute hemorrhagic fields bounded by a capsule. A postpartum tonsillectomy was planned for our patient. Tonsillectomy must be performed to patients followed up with this diagnosis in order to differentiate between dysphagia, risks of bleeding and aspiration, and malignant tumors.

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Tonsillar haemorrhage and measles

Cited by 16 publications

References 2 publications

Infection of lymphoid tissues in the macaque upper respiratory tract contributes to the emergence of transmissible measles virus

Infection of lymphoid tissues in the macaque upper respiratory tract contributes to the emergence of transmissible measles virus

Indications for tonsillectomy stratified by the level of evidence

Spontaneous Intracapsular Tonsillar Hemorrhage

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