Tonography in Cornea Guttata

Buxton, Jorge N.; Preston, Robert W.; Riechers, Robert J.; Guilbault, Normand

doi:10.1001/archopht.1967.00980020604007

Cited by 16 publications

(3 citation statements)

References 3 publications

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“…Buxton et al30 found that the drainage of aqueous outflow was decreased in eyes of FECD patients as compared to normal controls. The study concluded that the trabecular meshwork might be involved in the disease process.…”

Section: What We Knowmentioning

confidence: 98%

Fuchs Endothelial Corneal Dystrophy

2010

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Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive loss of corneal endothelial cells, thickening of Descement’s membrane and deposition of extracellular matrix in the form of guttae. When the number of endothelial cells becomes critically low, the cornea swells and causes loss of vision. The clinical course of FECD usually spans 10–20 years. Corneal transplantation is currently the only modality used to restore vision. Over the last several decades genetic studies have detected several genes, as well as areas of chromosomal loci associated with the disease. Proteomic studies have given rise to several hypotheses regarding the pathogenesis of FECD. This review expands upon the recent findings from proteomic and genetic studies and builds upon recent advances in understanding the causes of this common corneal disorder.

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Section: What We Knowmentioning

confidence: 98%

Fuchs Endothelial Corneal Dystrophy

2010

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“…Previous studies demonstrate conflicting evidence on the association between FED and OAG. Buxton et al 9 and Kolker and Hetherington 10 reported a connection between corneal guttae of FED and POAG based on a lower facility of outflow and an elevated IOP/outflow facility ratio. Burns et al 11 challenged these findings and in some cases 12 , 13 demonstrated a negative relationship between corneal guttae from FED and elevated IOP.…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of the association between Fuchs’ endothelial dystrophy and glaucoma

Rice

Wright

Silverstein

2014

OPTH

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ObjectiveThe goal of this study was to examine a possible clinical association between Fuchs’ endothelial dystrophy (FED) and glaucoma suspect (GS)/ocular hypertension (OHT) or open angle glaucoma (OAG).MethodsA retrospective chart review was carried out using data from electronic medical records and paper records from a private ophthalmology clinic in Kansas City, MO, USA. The review included 257 patients with FED and 584 randomly selected controls with no history of endothelial dystrophy. Binomial and multinomial regression using generalized estimating equations was used to create models to examine the correlation between FED diagnosis/severity and glaucoma diagnosis/type of glaucoma adjusted for age, sex, presence of diabetes, number of guttae, and intraocular pressure (IOP).ResultsNo statistically significant increase in prevalence of either OHT or GS/OHT compared to controls was observed (P>0.3). There was a statistically significant positive correlation between increasing age and IOP with increased glaucoma prevalence (P<0.05). There was also a statistically significant positive correlation between increasing age, IOP and male sex, with increased prevalence of the more severe glaucoma subtype of OAG versus GS/OHT and controls (P<0.05). Increasing severity of FED divided into category 1 and 2 based upon number of guttae was not associated with any significant increase in glaucoma prevalence (P>0.09), and was actually significantly negatively correlated to worsening glaucoma subtype for category 2 FED patients (P<0.05). Diabetes was not associated with the prevalence of either glaucoma or its subtypes of GS/OHT or OAG.ConclusionThe correlation between FED and glaucoma has been controversial. This study showed no statistically significant association between FED and glaucoma by prevalence or severity of FED as measured by corneal guttae. Further study is needed to determine if a connection between FED and glaucoma does exist, and if so, whether this relationship may impact earlier the detection and treatment of disease.

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“…Regarding the first case, conflicting evidence exists for compromised aqueous outflow in corneal guttata and FED. [37][38][39][40] The second alternative seems less likely because a cornea thickened by DSAEK is expected to require more deformation force and cause an overestimation of IOP, particularly by applanation tonometers that depend on CCT and corneal rigidity. [14][15][16][17][18] Figure 3B provides some support that higher IOP measurements are obtained from thicker grafted corneas (slope = 0.21 6 0.14 mm Hg/10 mm; r 2 = 0.072; P = 0.14).…”

Section: Discussionmentioning

confidence: 99%