Tonic Pupils and Absent Tendon Reflexes: A Benign Disorder Sui Generis; Its Complete and Incomplete Forms

Adie, W. J.

doi:10.1001/archneur.1968.00470360132016

Cited by 12 publications

(49 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Holmes-Adie syndrome1 2 (tonic pupil, near-light dissociation, and tendon areflexia) has been associated with a range of autonomic disturbance that includes orthostatic hypotension,3 impairment of cardiovascular reflexes,4 5 segmental6 and generalised hypohydrosis (Ross’s syndrome),7 carotid gustatory syndrome,8 and chronic diarrhoea 9. Limited histological studies in this condition indicate loss of ganglion cells in the parasympathetic ciliary ganglia10 which correlates with the pupillary abnormalities.…”

mentioning

confidence: 99%

Chronic cough in the Holmes-Adie syndrome: association in five cases with autonomic dysfunction

Kimber

Mitchell

Mathias

1998

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

The Holmes-Adie syndrome consists of unilateral or bilateral tonic pupils with near light dissociation and tendon areflexia. It is associated with autonomic disturbances aVecting sudomotor and vasomotor function. Five such patients are reported on who also had a troublesome chronic dry cough, which was of unknown aetiology and was resistant to a range of treatments. The cough may be related to involvement of aVerent or eVerent pathways in the vagus. Chronic cough may be an accompaniment in the HolmesAdie syndrome, like other forms of autonomic dysfunction. (J Neurol Neurosurg Psychiatry 1998;65:583-586)

show abstract

mentioning

confidence: 99%

Chronic cough in the Holmes-Adie syndrome: association in five cases with autonomic dysfunction

Kimber

Mitchell

Mathias

1998

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

show abstract

“…The VGCCs may be classified by their electrophysiological characteristics into at least four subtypes (T, L, N, and P).2 3 We have previously detected antibodies to N-type VGCCs in a proportion of patients with LEMS using co-conotoxin GVIA (a-CgTx), purified from the fish hunting cone snail (Conus geographus), which blocks neuronal Ntype VGCCs.4 Similar assays have been described by Sher and colleagues5 and Lennon and Lambert.6 In our series, however, less than 50% of serum samples were clearly positive and some autoimmune disease controls gave equivocal results. 4 counting.…”

mentioning

confidence: 99%

An improved diagnostic assay for Lambert-Eaton myasthenic syndrome.

Motomura

Johnston

Lang

et al. 1995

Journal of Neurology, Neurosurgery & Psychiatry

246

131

View full text Add to dashboard Cite

show abstract

“…The near responses were generally normal in amplitude (albeit tonic) in all patients, and there was no significant difference between the groups. Light-near dissociation (defined as NR>LR) was more commonly observed in Adie/Ross patients (43/53 cases) than in neuropathy patients (31/65 cases) (χ2 = 12.567; p<0.001). Moreover, the degree of light-near dissociation (LND) was greater in Adie/Ross patients compared with neuropathy patients (t = 3.901; p<0.001).…”

Section: Resultsmentioning

confidence: 99%

“…Holmes–Adie syndrome (HAS)1 2 is an idiopathic condition occurring most commonly in young women. The typical pupil findings include attenuation of the light response, sector palsy,3 a “tonic” near response (large amplitude but slow velocity miosis on accommodative effort) and denervation supersensitivity to dilute muscarinic receptor agonists.…”

mentioning

confidence: 99%