Tonic effects of the dopaminergic ventral midbrain on the auditory cortex of awake macaque monkeys

Huang, Ying; Mylius, Judith; Scheich, Henning; Brosch, Michael

doi:10.1007/s00429-014-0950-2

Cited by 13 publications

(8 citation statements)

References 40 publications

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“…Bao et al showed that the pairing of VTA stimulation with an auditory stimulus increases the selectivity of neural responses to that sound in rats (Bao et al, 2001). Similar results were subsequently reported by Brosch in primates (Huang et al, 2016). The release of dopamine from the VTA to several brain centres, such as the nucleus accumbens, globus pallidus and orbitofrontal cortex, represents a key mechanism to link sensory stimuli to their rewarding attributes (Schultz, 2016).…”

Section: Neuromodulatory Systems and The Auditory Cortexmentioning

confidence: 60%

“…In addition to the well-defined ascending auditory stream that carries information about the spectral, temporal and spatial characteristics of sounds, the auditory cortex is the recipient of fibres from neuromodulatory systems, i.e., the cholinergic, dopaminergic, noradrenergic and serotoninergic systems, that are widely engaged by emotionally laden events (Atzori et al, 2005;Letzkus et al, 2011;Happel et al, 2014;Roozendaaland and McGaugh, 2011;Schultz, 2016;Stark and Scheich 1997). In addition, many studies demonstrated that these systems can shape and drive also the processing of sounds within the auditory cortex (Bao et al 2001;Edeline et al, 2011;Huang et al, 2016;Letzkus et al, 2011;Martins and Froemke, 2015). Therefore, these systems might contribute to provide information to the auditory cortex about the emotional content of sounds.…”

Section: Neuromodulatory Systems and The Auditory Cortexmentioning

confidence: 99%

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The auditory cortex and the emotional valence of sounds

Concina

Renna

Grosso

et al. 2019

Neuroscience & Biobehavioral Reviews

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How and where sensory stimuli, such as tones or lights, are linked to valence is an important unresolved question in the field of neuroscience. The auditory cortex is essential to analyse the identity and the behavioural importance of tones paired with emotional events. On the contrary, whether the auditory cortex may also encode information on the emotional-motivational valence of sounds is much more controversial. Here, we reviewed recent studies showing that the activity of cortical neurons reflects information about the content of emotional stimuli paired with tones. Critically, the blockade of these neuronal processes prevents animals from recognising sounds as aversive or pleasant. Based on these findings, we proposed a conceptual model in which the auditory cortex may incorporate ascending information from subcortical nuclei about the valence of sounds in sound representations and may consequently drive the activity of subcortical structures towards emotionally laden tones. This hypothesis may also have important implications in the characterisation of neural circuits engaged by maladaptive affective disorders, such as phobias.

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Section: Neuromodulatory Systems and The Auditory Cortexmentioning

confidence: 60%

Section: Neuromodulatory Systems and The Auditory Cortexmentioning

confidence: 99%

The auditory cortex and the emotional valence of sounds

Concina

Renna

Grosso

et al. 2019

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

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“…Such changes may arise from task- and meaning-specific changes of stimulus-specific adaptation, forward suppression, or receptive field properties of neurons in auditory cortex or in earlier stages of the auditory system (Atiani et al, 2009; Groh et al, 2001; Gruters et al, 2018; Metzger et al, 2006). These changes may be mediated by sub-cortical neuromodulator systems, for example cholinergic and dopaminergic nuclei (Ayala and Malmierca, 2015; Huang et al, 2016b), or by higher-order associative systems, for example prefrontal cortex (Gao et al, 2017; Winkowski et al, 2013; Winkowski et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Associations between sounds and actions in early auditory cortex of nonhuman primates

Huang

Heil

Brosch

2019

eLife

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An individual may need to take different actions to the same stimulus in different situations to achieve a given goal. The selection of the appropriate action hinges on the previously learned associations between stimuli, actions, and outcomes in the situations. Here, using a go/no-go paradigm and a symmetrical reward, we show that early auditory cortex of nonhuman primates represents such associations, in both the spiking activity and the local field potentials. Sound-evoked neuronal responses changed with sensorimotor associations shortly after sound onset, and the neuronal responses were largest when the sound signaled that a no-go response was required in a trial to obtain a reward. Our findings suggest that association processes take place in the auditory system and do not necessarily rely on association cortex. Thus, auditory cortex may contribute to a rapid selection of the appropriate motor responses to sounds during goal-directed behavior.

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“…However, these changes are likely mechanistically distinct from the action of norepinephrine. While the predominant feature of noradrenergic modulation in AI is reduction of tonic inhibition, dopaminergic modulation has a wide variety of effects including regulation of cAMP levels, enhancement of NMDA receptor signaling, and decreases of spontaneous spiking 48 , 49 .…”

Section: Discussionmentioning

confidence: 99%

Coordinated forms of noradrenergic plasticity in the locus coeruleus and primary auditory cortex

2015

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The cerebral cortex is plastic and represents the world according to the significance of sensory stimuli. However, cortical networks are embodied within complex circuits including neuromodulatory systems such as the noradrenergic locus coeruleus, providing information about internal state and behavioral relevance. While norepinephrine is important for cortical plasticity, it is unknown how modulatory neurons themselves respond to changes of sensory input. Here we examine how locus coeruleus neurons are modified by experience, and the consequences of locus coeruleus plasticity on cortical representations and sensory perception. We made whole-cell recordings from rat locus coeruleus and primary auditory cortex (AI), pairing sounds with locus coeruleus activation. Although initially unresponsive, locus coeruleus neurons developed and maintained auditory responses afterwards. Locus coeruleus plasticity induced changes in AI responses lasting at least hours and improved auditory perception for days to weeks. Our results demonstrate that locus coeruleus is highly plastic, leading to substantial changes in regulation of brain state by norepinephrine.

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Tonic effects of the dopaminergic ventral midbrain on the auditory cortex of awake macaque monkeys

Cited by 13 publications

References 40 publications

The auditory cortex and the emotional valence of sounds

The auditory cortex and the emotional valence of sounds

Associations between sounds and actions in early auditory cortex of nonhuman primates

Coordinated forms of noradrenergic plasticity in the locus coeruleus and primary auditory cortex

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