Tongue pressure as a novel biomarker of spinal and bulbar muscular atrophy

Mano, Tomoo; Katsuno, Masahisa; Banno, Haruhiko; Suzuki, Keisuke; Suga, Noriaki; Hashizume, Akira; Araki, Atsuko; Watanabe, Haruo; Tanaka, Seiya; Yamamoto, Masahiko; Sobue, Gen

doi:10.1212/wnl.0000000000000041

Cited by 57 publications

(71 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some previous surveys have also used the time of 7 seconds (1,21) , whereas others have used a shorter time, between two and three seconds (19,22,26,28) , but these studies that used shorter contraction times evaluated only maximum tongue force, whereas the present study also assessed mean tongue force. In order not to obtain results with variations caused by muscle fatigue, a rest period was observed between measurements; as in previous studies, this time was one minute (1,13,(21)(22)(23)(24) . In addition to the good reproducibility of the data, it is worth noting that the software that accompanies the Forling instrument is easy to use, enabling modification of the data recording time and data visualization during measurement, allowing the instrument to be used in different ways and without need of extensive training.…”

Section: Discussionmentioning

confidence: 93%

“…They were instructed about the operation of the instrument and requested to insert the mouthguard into their oral cavity comfortably. The examiner then waited 15 seconds for participants to get used to mouthguard and instructed them to protrude the tongue with the greatest possible force upon request, triggering the device that measures the tongue force for seven seconds (1,21) ; participants had no access to the test results. All instrumental assessments were conducted by the same previously trained examiner.…”

Section: Thismentioning

confidence: 99%

“…On each day, three measurements were taken using the Forling instrument with one-minute intervals between them (1,13,(21)(22)(23)(24) . Software developed in the LabView platform showed the force values in newton (N) in real time and recorded the force graphs over time.…”

Section: Thismentioning

confidence: 99%

See 2 more Smart Citations

Avaliação da reprodutibilidade de um instrumento para medição da força axial da língua

Araújo

Rodrigues

Furlan

et al. 2018

CoDAS

View full text Add to dashboard Cite

RESUMO Objetivo Avaliar a reprodutibilidade do Forling, instrumento portátil para medição da força axial da língua. Método Foi realizada a medição da força axial da língua de 49 participantes, 30 mulheres e 19 homens, com idades entre 18 e 25 anos por meio do Forling portátil. As medições foram realizadas em três dias com intervalos de 7±2 dias. Em cada dia, foram realizadas três coletas com duração de 7 segundos e intervalos de 1 minuto. Na análise, empregou-se coeficiente de variação, teste pareado de Wilcoxon e coeficiente de correlação intraclasse. Foram analisados os valores de força máxima e média da língua, sendo a comparação dos valores realizada em três abordagens: utilizando-se a média dos três valores; a média dos dois maiores valores; e o maior valor de cada medição. Resultados Na análise da força média, o coeficiente de variação foi considerado desejável e o coeficiente de correlação intraclasse aceitável. Houve diferenças significativas entre o máximo valor comparando o segundo e terceiro dias, entre a média dos dois maiores valores e entre a média dos três valores comparando o primeiro e segundo dias, bem como o segundo e terceiro dias. Na análise da força máxima, o coeficiente de variação e o coeficiente de correlação intraclasse foram aceitáveis. Somente comparando o segundo e terceiro dias, foi encontrada diferença significativa. Conclusão Observou-se boa reprodutibilidade dos dados obtidos com o uso do Forling portátil.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Thismentioning

confidence: 99%

See 1 more Smart Citation

Avaliação da reprodutibilidade de um instrumento para medição da força axial da língua

Araújo

Rodrigues

Furlan

et al. 2018

CoDAS

View full text Add to dashboard Cite

show abstract

“…We previously reported that tongue pressure may serve as a marker of swallowing function at an early stage of SBMA 29. VFSS enables visualization of the swallowing movement, while tongue pressure assesses a part of the swallowing function.…”

Section: Discussionmentioning

confidence: 99%

Swallowing markers in spinal and bulbar muscular atrophy

Banno

Katsuno

Suzuki

et al. 2017

Ann Clin Transl Neurol

View full text Add to dashboard Cite

ObjectiveWe examined the characteristics of dysphagia in spinal and bulbar muscular atrophy, a hereditary neuromuscular disease causing weakness of limb, facial, and oropharyngeal muscles via a videofluoroscopic swallowing study, and investigated the plausibility of using these outcome measures for quantitative analysis.MethodsA videofluoroscopic swallowing study was performed on 111 consecutive patients with genetically confirmed spinal and bulbar muscular atrophy and 53 age‐ and sex‐matched healthy controls. Swallowing of 3‐mL liquid barium was analyzed by the Logemann's Videofluorographic Examination of Swallowing worksheet.ResultsOf more than 40 radiographic findings, the most pertinent abnormal findings in patients with spinal and bulbar muscular atrophy, included vallecular residue after swallow (residue just behind the tongue base), nasal penetration, and insufficient tongue movement (P < 0.001 for each) compared with healthy controls. Quantitative analyses showed that pharyngeal residue after initial swallowing, oral residue after initial swallowing, multiple swallowing sessions, and the penetration–aspiration scale were significantly worse in these patients (P ≤ 0.005 for each) than in controls. In patients with spinal and bulbar muscular atrophy, laryngeal penetration was observed more frequently in those without subjective dysphagia.InterpretationDysphagia of spinal and bulbar muscular atrophy was characterized by impaired tongue movement in the oral phase and nasal penetration followed by pharyngeal residues, which resulted in multiple swallowing sessions and laryngeal penetration. Although major limitations of reproducibility and radiation exposure still exist with videofluoroscopy, pharyngeal residue after initial swallowing and the penetration–aspiration scale might serve as potential outcome measures in clinical studies.

show abstract

“…Significant changes in grip strength have been observed in a 3-year longitudinal study of SBMA patients [107] but no significant change over a one year period was detected in another study [103]. A recent study evaluated the measure of tongue pressure using an intraoral pressure probe [108]. This measure seems to be reliable but longitudinal studies are required to confirm its use as biomarker of disease progression.…”

Section: Biomarkersmentioning

confidence: 99%

Kennedy disease (X-linked recessive bulbospinal neuronopathy): A comprehensive review from pathophysiology to therapy

2017

View full text Add to dashboard Cite

Acknowledgments: the authors thank AFM-Téléthon, Téléthon Biobank, Institut pour la Recherche sur la Moelle épinière et l'Encéphale (IRME), Association pour la Recherche sur la SLA (ARSla) and the University of Padova for their research support.Kennedy disease (X-Linked recessive Bulbospinal Neuronopathy): a comprehensive review from pathophysiology to therapy. AbstractKennedy's disease, also known as spinal and bulbar muscular atrophy (SBMA), is a rare, adult-onset, Xlinked recessive neuromuscular disease. It is caused by expansion of a CAG repeat sequence in exon 1 of the androgen-receptor (AR) gene, encoding a poly-glutamine (polyQ) tract. Poly-Q-expanded AR accumulates in nuclei and initiates degeneration and loss of motor neurons and dorsal root ganglia. The disease has been retained to be a pure lower motor neuron disease for a long time, but recently the presence of important hyper-Creatine-Kinase-emia and of myopathic alterations on muscle biopsy has suggested the presence of a primary myopathy underlying a wide proportion of clinical manifestations. The disease, that affects male adults, is characterized by muscle weakness and atrophy localized proximally in the limbs and by bulbar involvement. Sensory disturbances are associated to the motor phenotype but may be subclinical. The most frequent systemic symptom is gynecomastia related to androgen insensitivity, but other abnormalities, such as heart rhythm and urinary disturbances, have also been reported. The course of the disease is slowly progressive with normal life expectancy. The diagnosis of SBMA is based on genetic testing, with 38 CAG repeats retained to be pathogenic. Even though several therapeutic attempts have been made in mouse models, no effective disease modifying therapy is available but symptomatic therapy is beneficial for the management of weakness, fatigability and bulbar symptoms.

show abstract

Tongue pressure as a novel biomarker of spinal and bulbar muscular atrophy

Cited by 57 publications

References 32 publications

Avaliação da reprodutibilidade de um instrumento para medição da força axial da língua

Avaliação da reprodutibilidade de um instrumento para medição da força axial da língua

Swallowing markers in spinal and bulbar muscular atrophy

Kennedy disease (X-linked recessive bulbospinal neuronopathy): A comprehensive review from pathophysiology to therapy

Contact Info

Product

Resources

About