Tongue necrosis secondary to giant cell arteritis, successfully treated with tocilizumab: a case report

Abstract

Abstracts Background Giant Cell Arteritis (GCA) is a large vessel vasculitis that most commonly presents with headache, scalp tenderness, jaw claudication, and vision changes. Various other, less common, manifestations have been reported in the literature such as scalp and tongue necrosis. Though most patients respond to corticosteroids, some cases of GCA are refractory to the high doses of corticosteroids. Case presentation We present a 73-year-old female with GCA refractory to corticosteroids presenting with tongue necrosis. This patient significantly improved with a dose of tocilizumab, an IL-6 inhibitor. Conclusion To the best of our knowledge, this is the first case report of a patient with refractory GCA presenting with tongue necrosis that had rapid improvement with tocilizumab. Prompt diagnosis and treatment can prevent severe outcomes such as tongue amputation in GCA patients with tongue necrosis, and tocilizumab may be effective for corticosteroid-refractory cases.

Necrosis of the tongue as a clinical manifestation of giant cell arteritis

“…Die Glukokortikoidtherapie ist unverzüglich einzuleiten, um schwerwiegende Komplikationen der Vaskulitis wie z. B. eine ausgedehnte Nekrose der Zunge und eine hieraus resultierende Notwendigkeit einer Zungenamputation zu vermeiden [ 12 ].…”