Tongue disease in advanced AIDS

Faria, Paulo Rogério de; Vargas, Pablo Agustı́n; Saldiva, Paulo Hilário Nascimento; Böhm, György; Mauad, Thaís; Almeida, Oslei Paes de

doi:10.1111/j.1601-0825.2004.01070.x

Cited by 34 publications

(30 citation statements)

References 38 publications

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“…This rate is lower than other studies 5,13 , in which mouth was much more commonly affected. This difference is probably due to methodology used, because, instead of the cited work 5 , we did not do a global study of oral cavity, but only of tongue.…”

Section: Discussioncontrasting

confidence: 48%

“…This difference is probably due to methodology used, because, instead of the cited work 5 , we did not do a global study of oral cavity, but only of tongue. In our study we found 8% of cases of oral hairy leukoplakia, while other works found this lesion as the most frequent, present in 35.5% of 45 autopsies and in 45.6% of 92 autopsies, respectively 5,13 . It is possible that some of this difference is related to sampling for microscopy.…”

Section: Discussioncontrasting

confidence: 46%

“…It is possible that some of this difference is related to sampling for microscopy. In our study, tongue was sampled randomly or in sites with macroscopic lesion, instead of another autopsy study that exclusively evaluated tongue, in which several regions were represented histologically by prior standardization 13 . Moreover, another factor that may explain this difference is the subjectivity in microscopic evaluation of lesion, based mainly in morphological criteria 14 .…”

Section: Discussionmentioning

confidence: 99%

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Morphological changes in the digestive system of 93 human immunodeficiency virus positive patients: an autopsy study

Guimarães

Silva

Micheletti

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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SUMMARYInvolvement of the digestive system in patients with acquired immunodeficiency syndrome (AIDS) is frequent and many changes in these patients are diagnosed only at autopsy. There are few studies of autopsy with detailed analysis of this system and only one was conducted in Brazil. We evaluated each segment of the digestive system in 93 consecutive autopsies of patients infected with human immunodeficiency virus (HIV) and the importance of these lesions to death. Of these, 90 (96.8%) patients had AIDS. We reviewed medical records, autopsy reports and histological sections from tongue to rectum stained with hematoxylin-eosin. When necessary, we analyzed special stains and immunohistochemistry to investigate infections. There was damage to the digestive system in 73 (78.5%) cases. The most common infections were candidiasis (42%), cytomegalovirus (29%), histoplasmosis (11.8%), toxoplasmosis (9.7%) and mycobacterial infection (9.7%). Malignancies were rare, present in four (4.3%) cases (two Kaposi's sarcoma, one adenocarcinoma and one metastatic embryonal carcinoma). All segments showed lesions: tongue (48.6%), esophagus (44.8%), stomach (44.7%), colon (43.2%) and small intestine (28.9%). The lesions found were immediate cause of death in five (5.4%) cases. In another 36 (38.7%) cases the basic disease was systemic and also compromised the digestive system.

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Section: Discussioncontrasting

confidence: 48%

Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

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Morphological changes in the digestive system of 93 human immunodeficiency virus positive patients: an autopsy study

Guimarães

Silva

Micheletti

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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“…2,3 An important line of investigation by our group refers to the study of the oral alterations found during autopsy in patients who had died due to complications of human immunodeficiency virus infection. 4,5 Although not a common field of study by oral pathologists, autopsybased investigations represent an unmeasured source of data for better understanding the oral manifestations of systemic diseases, especially in developing countries, where infections still represent major causes of death. The microscopic analysis of autopsies can also provide a better comprehension of normal structures not commonly evaluated in regular oral biopsies, such as the posterior area or the base of the tongue.…”

Section: To the Editormentioning

confidence: 99%

Neuroepithelial structures associated with neurogenous subgemmal plaque of the tongue: an autopsy finding

Fonseca

Moreira

Almeida

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…Many of these HIV-positive patients present manifestations involving the maxillofacial region in all stages of the disease, and, in some cases, the oral lesions are the first signs of infection. [910] With disease progression, the deleterious effect of HIV on the immune system results in an escalating incidence of widely recognized and extensively described OIs and diseases, among which are the oral manifestations of HIV and, since the onset of the HIV pandemic, oral lesions have been well documented as early markers of HIV infection and as predictors of HIV disease progression. [1112] Oral manifestations can suggest decreased cluster-differentiated 4 (CD4+) T cell count and increased viral load, which might also aid in the diagnosis, progression, and prognosis of the disease.…”

Section: Introductionmentioning

confidence: 99%

Oral lesions: A true clinical indicator in human immunodeficiency virus

Saini¹

2011

J Nat Sc Biol Med

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From the onset of the human immunodeficiency virus (HIV) epidemic over 20 years ago (since the appearance of the first cases of contamination by the HIV virus in the 1980s), more than 60 million people have become infected and more than 20 million people have died. An estimated 15,000 new infections occur each day, with more than 95% of these in developing countries. The distinctive characteristic in the pathogenesis of HIV/acquired immunodeficiency syndrome is that the primary target cell for HIV is immune cells bearing the CD4 marker at their surface, and the CD4 cell count and viral load have been used lately as the most important laboratory parameters to evaluate the evolution of the disease. Oral lesions are common (30–80%) in patients infected by the HIV virus and may indicate an impairment in the patient's general health status and, consequently, a poor prognosis. Oral manifestations can suggest decreased cluster-differentiated (CD4+) T cell count and increased viral load, which might also aid in diagnosis, progression, and prognosis of the disease. At the tertiary level of oral care, a dentist should be available to make definitive diagnoses of oral lesions and provide professional oral services such as prophylaxis, restorations, biopsies, and the prescription of appropriate medication.

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Tongue disease in advanced AIDS

Abstract: These findings indicate that the tongue is a favorite site to occurrence of reactive, infectious and concurrent lesions in the end-stage of AIDS patients.

Cited by 34 publications

References 38 publications

Morphological changes in the digestive system of 93 human immunodeficiency virus positive patients: an autopsy study

Morphological changes in the digestive system of 93 human immunodeficiency virus positive patients: an autopsy study

Neuroepithelial structures associated with neurogenous subgemmal plaque of the tongue: an autopsy finding

Oral lesions: A true clinical indicator in human immunodeficiency virus

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