Tongue development in stillborns autopsied at different gestational ages

Aguiar, Laura Sanches; Juliano, Guilherme Ribeiro; Silveira, Luciano Alves Matias da; Oliveira, Mariana; Torquato, Bianca Gonçalves Silva; Juliano, Gabriela Ribeiro; Araújo, Márcia Fernandes de; Pereira, Sanívia Aparecida de Lima; Teixeira, Vicente de Paula Antunes; Ferraz, Mara Lúcia Fonseca

doi:10.1016/j.jpedp.2017.11.010

Cited by 1 publication

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data showed a positive and significant correlation between all 4 tongue biometric measurements and the GA best expressed by a cubic polynomial regression formula. This is in agreement with previous studies 3–6 …”

Section: Discussionsupporting

confidence: 94%

“…This is in agreement with previous studies. [3][4][5][6] The strengths of the study are its prospective design, strict adherence to inclusion and exclusion criteria and relatively large sample size for each week, all contributing to the quality of the nomogram. Furthermore, multiple examiners participated in acquiring measurements with high intra-and interclass correlation, strengthening the reproducibility of tongue measurements.…”

Section: Discussionmentioning

confidence: 99%

“…Throughout pregnancy, the tongue continuously increases in size. [3][4][5][6][7] Abnormal fetal tongue size is a phenotypic feature of various significant congenital syndromes and conditions including Down syndrome, Beckwith-Wiedemann Syndrome, Pierre-Robin Sequence, Simpson-Golabi, Oromandibular Limb Hypoplasia, mucopolysaccharidoses, chromosomal abnormalities, and more. 1,3,5,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Tongue anomalies may present as an isolated finding 9,10,15 and, occasionally, it may be the only presenting prenatal feature of a genetic syndrome.…”

Section: Introductionmentioning

confidence: 99%

“…The body and root of the tongue are separated by a groove termed “terminal sulcus” 1,2 (Figure 1). Throughout pregnancy, the tongue continuously increases in size 3–7 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Fetal Micro and Macroglossia

Koren

Shust-Barequet

Weissbach

et al. 2022

J of Ultrasound Medicine

View full text Add to dashboard Cite

Objectives Abnormal fetal tongue size is a phenotypic feature of various syndromes including Beckwith‐Wiedemann, Pierre‐Robin, oromandibular limb hypoplasia, chromosomal aberrations, etc. Current data regarding normal fetal tongue size are limited. Hence, micro/macroglossia are subjectively determined. The aim of the study was to construct a contemporary fetal tongue nomogram and to assess its clinical contribution. Methods A prospective cross‐sectional study was performed in well dated, low risk, singleton pregnancies. Fetal tongues were measured by 5 trained sonographers. Highest quality images were selected. Intra‐ and interobserver variability was assessed. Tongue length, width, area, and circumference 1st to 99th centiles were calculated for each gestational week. Based on the normal tongue size charts, we created a Tongue Centile Calculator. Results Over 18 months, 664 tongue measurements were performed. A cubic polynomial regression model best described the correlation between tongue size and gestational age. The correlation coefficient (r2) was 0.934, 0.932, 0.925, and 0.953 for tongue length, width, area, and circumference, respectively (P < .001). Intra‐ and interobserver variability had high interclass correlation coefficients (>0.9). Using the new charts, we were able to identify 2 cases of macroglossia, subsequently diagnosed with Beckwith‐Wiedemann, and 4 cases of microglossia, 3 associated with Pierre‐Robin sequence, and 1 associated with persistent buccopharyngeal membrane. Conclusions We present novel fetal tongue size charts from 13 to 40 weeks of gestation. Clinical application of these nomograms may be beneficial in the prenatal diagnosis of syndromes or malformations associated with abnormal fetal tongue size.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The body and root of the tongue are separated by a groove termed “terminal sulcus” 1,2 (Figure 1). Throughout pregnancy, the tongue continuously increases in size 3–7 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations