Tongue-coating microbiome as a cancer predictor: A scoping review

Mohammed, Marwan Mansoor Ali; Kawas, Sausan Al; Al-Qadhi, Gamilah

doi:10.1016/j.archoralbio.2021.105271

Cited by 7 publications

(3 citation statements)

References 64 publications

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“…In general, Firmicutes predominance was inversely related to Fusobacteria , Actinobacteria , Proteobacteria and Bacteroidetes , whereas the relative abundance of Streptococcus genus was inversely associated with the presence of Prevotella , Actinomyces , Fusobacterium , Leptotrichia and Neisseria ( 2 ). In a recent scoping review, performed on 274 papers of which only 9 eligible, authors reported that the association between oral tumors and oral microbiome was significant when changes in the microbiota composition occurred, particularly when an impaired abundance of the phyla Firmicutes, Fusobacteria and Actinobacteria and some species of the genus Streptococcus, Actinomyces, Leptotrichia, Campylobacter e Fusobacterium were predominant in the oral microbiome ( 38 ). In this study, tongue-related microbiome has been used as a predictor of cancers in the oral cavity ( 38 ).…”

Section: The Oral Microbiome Composition In the Hygiene Perspective O...mentioning

confidence: 99%

“…In a recent scoping review, performed on 274 papers of which only 9 eligible, authors reported that the association between oral tumors and oral microbiome was significant when changes in the microbiota composition occurred, particularly when an impaired abundance of the phyla Firmicutes, Fusobacteria and Actinobacteria and some species of the genus Streptococcus, Actinomyces, Leptotrichia, Campylobacter e Fusobacterium were predominant in the oral microbiome ( 38 ). In this study, tongue-related microbiome has been used as a predictor of cancers in the oral cavity ( 38 ). It would be interesting to assess the role of such microbiomes in tongue cancers, as well, as still representing a huge concern in oral oncology ( 39 , 40 ).…”

Section: The Oral Microbiome Composition In the Hygiene Perspective O...mentioning

confidence: 99%

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Oral microbiota in oropharyngeal cancers: Friend or foe?

Nocini

Muzio²,

Gibellini³

et al. 2022

Front. Oncol.

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Oral microbiome is a complex population of micro-organisms, which by cross-talking with the local immune system, plays a major role in the immune homeostasis of the oral cavity, further contributing in the physiology of the gastro-intestinal microbiota. Understanding their involvement in the onset and pathogenesis of oropharyngeal cancers is paramount, despite very few reports deal with the fundamental role exerted by oral microbiota disorders, such as dysbiosis and impairment in the oral microbiome composition as causative factors in the development of oropharyngeal tumors. Current research, via metabolomic or meta-transcriptomic analyses, is wondering how this complex microbial population regulates the immune homeostasis in oral and pharyngeal mucosa and whether changes in bacterial composition may give insights on the role of oral microbiome in the development of oropharyngeal tumors, so to prevent their occurrence.

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Section: The Oral Microbiome Composition In the Hygiene Perspective O...mentioning

confidence: 99%

Section: The Oral Microbiome Composition In the Hygiene Perspective O...mentioning

confidence: 99%

Oral microbiota in oropharyngeal cancers: Friend or foe?

Nocini

Muzio²,

Gibellini³

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

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“…The researchers found that it has a complex relationship with oral diseases (Kanasi et al, 2010 ; Shi et al, 2014 ) and systemic diseases (Pushalkar et al, 2012 ; Zhou et al, 2013 ). Recently, it was suggested that the microbiota dysbiosis of the tongue coat could facilitate the prognosis of several cancers (Ali Mohammed et al, 2021 ), such as pancreatic head carcinoma (Lu et al, 2019 ) and gastric cancer (Xu et al, 2021 ). But, the characteristics of the thick or greasy tongue-coating microbiota in patients with hepatocellular carcinoma are unclear.…”

Section: Introductionmentioning

confidence: 99%

Relationship between thick or greasy tongue-coating microbiota and tongue diagnosis in patients with primary liver cancer

et al. 2022

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Tongue diagnosis is a unique aspect of traditional Chinese medicine for diagnosing diseases before determining proper means of treatment, but it also has the disadvantage of relying on the subjective experience of medical practitioners and lack objective basis. The purpose of this article is to elucidate tongue-coating microbiota and metabolic differences in primary liver cancer (PLC) patients with thick or greasy tongue coatings. Tongue-coating samples were analyzed in 60 PLC patients (30 PLC with thick or greasy tongue-coating patients and 30 PLC with tongue-coating neither thick nor greasy) and 25 healthy controls (HC) using 16S rRNA gene sequencing technology. As compared to healthy individuals, tongue coatings of patients with PLC had elevated levels of Firmicutes and Actinobacteria. The abundance of Fusobacteria, SR1_Absconditabacteria_, and Spirochaete were higher in tongue coatings of healthy controls compared to samples in patients with PLC. In addition to site-specific differences, higher abundances of Fusobacteria and Actinobacteria were observed in thick or greasy tongue-coating patients as compared to non-thick and greasy tongue-coating patients. The inferred metagenomic pathways enriched in the PLC tongue-coating patients were mainly those involved in replication, recombination, and repair of protein. We also identify a tongue-coating microbiome signature to discriminate HC and PLC, including 15 variables on genus level. The prediction performance of the signature showed well in the training and validation cohorts. This research illustrates specific clinical features and bacterial structures in PLC patients with different tongue coatings, which facilitates understanding of the traditional tongue diagnosis.

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