Tongmai Yangxin pills anti-oxidative stress alleviates cisplatin-induced cardiotoxicity: Network pharmacology analysis and experimental evidence

Cui, Yameng; Li, Caihong; Zeng, Chao; Li, Jiao; Zhu, Zhihao; Chen, Wanli; Huang, Anan; Qi, Xin

doi:10.1016/j.biopha.2018.09.095

Cited by 60 publications

(39 citation statements)

References 25 publications

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“…With the rapid development of next-generation sequencing and bioinformatics technology, the critical roles of circRNAs in the human tumorigenesis have been explicated [28][29][30]. Besides, the biogenesis of circRNAs and its possible mechanisms similarly catch researcher's attention [31].…”

Section: Discussionmentioning

confidence: 99%

Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop

et al. 2019

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Emerging evidences have suggested the vital roles of circular RNA (circRNA) in the human cancers. However, the underlying biological functions and biogenesis of circRNA in the oral squamous cell carcinoma (OSCC) is still ambiguous. Here, we investigate the oncogenic roles and biogenesis of the novel identified circRNA, circUHRF1 (hsa_circ_0002185), in the OSCC tumorigenesis. Results showed that circUHRF1 was markedly upregulated in the OSCC cells and tissue, besides, the overexpression was closely correlated with the poor prognosis of OSCC patients. Functionally, circUHRF1 promoted the proliferation, migration, invasion, and epithelial mesenchymal transformation (EMT) in vitro and the tumor growth in vivo. Mechanically, circUHRF1 acted as the sponge of miR-526b-5p, thereby positively regulating c-Myc. Transcription factor c-Myc could accelerate the transcription of TGF-β1 and ESRP1. Moreover, splicing factor ESRP1 promoted the circularization and biogenesis of circUHRF1 by targeting the flanking introns, forming the circUHRF1/miR-526b-5p/c-Myc/ TGF-β1/ESRP1 feedback loop. In conclusion, our research identified the oncogenic roles of circUHRF1 in the OSCC tumorigenesis and EMT via circUHRF1/miR-526b-5p/c-Myc/TGF-β1/ESRP1 feedback loop, shedding light on the pathogenic mechanism of circUHRF1 for OSCC and providing the potential therapeutic target.

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Section: Discussionmentioning

confidence: 99%

Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop

et al. 2019

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“…Related articles (13) found that Tongmai Yangxin Pills have a protective effect on cardiomyocytes, and its mechanism may be related to antioxidant effects. Recent studies have shown (17,18) that a large amount of ROS produced by OS induces apoptosis, eventually changes the heart structure, causes abnormal heart function, and promotes the evolution of heart failure.…”

Section: Discussionmentioning

confidence: 99%

“…It has the effect of nourishing the heart and nourishing the blood, tongmai analgesia, and is used for the treatment of chest pain, heartache, angina pectoris, arrhythmia, etc (12). Studies (13) have shown that the myocardial protective effect of TMYXP may be related to antioxidant effects, but its mechanism has not yet been elucidated. Many active ingredients of TMYXP such as glycyrrhizic acid can inhibit ROS production through SIRT1/PGC-1α pathwayα (14).…”

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confidence: 99%

Tongmai Yangxin Pills Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy

Zhu

Chen

et al. 2020

Preprint

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Background: Mitochondrial biosynthesis regulated by the PGC-1α-NRF1-TFAM pathway is closely related to mitochondrial function and mitochondrial reactive oxygen generation, and is considered to be a new possible therapeutic target for the treatment of heart failure.Methods: Tongmai Yangxin Pills (TMYXP) is a Chinese patent medicine for the treatment of ischemic heart disease. It has the ability to scavenge oxygen free radicals and improve the antioxidant capacity of the heart muscle, thereby protecting cardiomyocytes, however, its mechanism is not well established. In this study, to investigate the mechanisms of TMYXP in cardiac protection, a rat model of cardiomyopathy was established by continuous isoproterenol (ISO) stimulation. Changes in the rat body weight, heart weight index (HWI), echocardiography, histological staining and biochemical indicators were examined.Results: Our results suggested that TMYXP reduced myocardial remodeling, inhibited deterioration of cardiac function, and delayed HF onset in rats with ISO-induced cardiomyopathy. Meanwhile, TMYXP markedly reduced ROS production, increased the levels of antioxidant enzymes, improved function of the mitochondrial respiratory chain, and promoted ATP production in myocardial tissues. In addition, TMYXP inhibited cytochrome C (Cyt C) release in mitochondria and caspase-3 activation in cytosol, thereby reducing the apoptosis of myocardial cells. Finally, TMYXP remarkably up-regulated the mRNA and protein expression levels of SIRT3, PGC-1α, NRF1 and TFAM in myocardial cells.Conclusions: Taken together, our results suggest that TMYXP regulates mitochondrial biosynthesis mediated enhancing the expression of SIRT3 and PGC-1α, thereby improving the cardiac function in rats with ISO-induced cardiomyopathy.

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“…TMYX consists of 11 Chinese medicinal herbs: Radix Rehmanniae, Caulis Spatholobi, Radix Glycyrrhizae, Ramulus Cinnamomi, Radix Ophiopogonis, Radix Polygoni multiflori preparata, Asini Corii colla, Fructus Schisandrae, Radix Codonopsis, Capapax et Plastrum Testudinis, and Fructus Jujubae. A recent study identified 80 compounds from a TMYX, including flavonoids, coumarins, iridoid glycosides, saponins, and lignans, exhibiting antiinflammatory activity [6]. A clinical study by Xuemeng Cai et al [7] indicated that TMYX in the treatment of stable coronary artery disease may be involved in energy metabolism, amino acid metabolism, oxidative stress, and inflammation.…”

Section: Introductionmentioning

confidence: 99%

Tongmai Yangxin intervening in myocardial remodeling after PCI for coronary heart disease: study protocol for a double-blind, randomized controlled trial

Wang

et al. 2020

Trials

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Background: Coronary heart disease (CHD) has become a common cardiovascular disease that seriously threatens the health of people. As reperfusion in the early phase and drug therapy, especially percutaneous coronary intervention (PCI), have become widely used in the clinic, the mortality of acute myocardial infarction in the short term has been reduced significantly. In addition, in 40%-56% of patients who experience myocardial infarction, cardiac dysfunction occurs and about 25%-33% develop heart failure. Methods: This study was designed as a multicenter, double-blind, randomized, placebo-controlled, parallelgroup, superiority trial. Participants were randomly assigned in a 1:1 ratio through a centrally controlled, computer-generated, simple randomization schedule. The primary outcome was left ventricular end-diastolic volume index = left ventricular end-diastolic volume/body surface area. The combined secondary outcomes include traditional Chinese medicine syndrome score, echocardiogram results, 6-minute walk test results, Seattle Angina Questionnaire score, cardiac magnetic resonance imaging results, biological indicators, dynamic electrocardiogram results, and experiment event rate. Assessments will be performed at baseline and at 4, 8, and 12 weeks after randomization. Discussion: This trial will demonstrate that the addition of a Tongmai Yangxin pill (TMYX) to conventional treatment will intervene in the development of cardiac remodeling and cardiac dysfunction.

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Tongmai Yangxin pills anti-oxidative stress alleviates cisplatin-induced cardiotoxicity: Network pharmacology analysis and experimental evidence

Cited by 60 publications

References 25 publications

Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop

Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop

Tongmai Yangxin Pills Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy

Tongmai Yangxin intervening in myocardial remodeling after PCI for coronary heart disease: study protocol for a double-blind, randomized controlled trial

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