Tong-xie-ning, a Chinese herbal formula, in treatment of diarrhea-predominant irritable bowel syndrome: a prospective, randomized, double-blind, placebo-controlled trial

Gang, Wang; Li, Ting-qian; Wang, Lei; Xia, Qing; Chang, Jing; Zhang, Ying; Wan, Mei-Hua; Guo, Jia; Chen, Yan; Huang, Xi; Zhang, Ruiming

doi:10.1097/00029330-200612020-00015

Cited by 24 publications

(21 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Literature searches identified 3782 potentially relevant titles after elimination of duplicates. After review of the abstracts, 121 full‐text publications were assessed, of which 50 studies were included in this review, involving a total of 7396 participants. As two of the studies shared the same group of patients with two aspects of results reported, so their data was abstracted as one, resulting in totally 49 trials for analysis.…”

Section: Resultsmentioning

confidence: 99%

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Tan

Gwee

Tack

et al. 2019

J of Gastro and Hepatol

View full text Add to dashboard Cite

Background and Aims The efficacy of herbal medicines (HMs) for functional gastrointestinal disorders (FGIDs) including irritable bowel syndrome (IBS), functional dyspepsia (FD) and functional constipation (FC) is controversial. A systematic review with meta‐analysis was conducted to determine their effectiveness for FGIDs. Methods We searched the following electronic databases till July 2019 with English language restriction: The Cochrane Library, EMBASE and PUBMED. Randomized double‐blind controlled trials of HMs compared with placebo or conventional pharmacological drugs for adult FGIDs patients were included. Results In total, 49 trials involving 7396 participants with FGIDs were included. The risk of bias was low in 9, unclear in 36, and high in 4 trials. More than 33 different herbal formulae were tested. HMs demonstrated statistically significant benefits for symptom improvement compared with placebo in 46 trials (RR = 1.67, 95% CI 1.48–1.88). When compared with conventional pharmacological therapy in 5 trials, HMs were found to be non‐inferior (RR = 1.10, 95% CI 1.03–1.18). The number of trials with regards to FD, IBS and FC were 19, 23 and 7 respectively. Subgroup analysis found that HMs were better than placebo in alleviating symptoms for FD (RR = 1.50, 95% CI 1.32–1.69), IBS (RR = 1.62, 95% CI 1.32–1.97) and FC (RR = 3.83, 95% CI 2.26–6.50). HMs tended to have more patients with adverse events than placebo, but similar to conventional pharmacological drugs. Conclusions Our findings provide a positive signal for HMs as a potentially well‐tolerated and effective treatment for FGIDs, deserving further examination in high‐quality trials.

show abstract

Section: Resultsmentioning

confidence: 99%

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Tan

Gwee

Tack

et al. 2019

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…Many trials have reported that TCM is beneficial for reducing IBS symptoms, but only 5 of the 75 randomized trials are of high quality. Three of 4 of these trials reported that TCM was beneficial for IBS 77 – 81 . A systematic review of 12 studies (1125 participants) of a TCM herbal concoction, Tong xie yao fang (TXYF), overall showed a beneficial effect on IBS symptoms 82 .…”

Section: Nutrition Factors In the Pathogenesis And Management Of Ibsmentioning

confidence: 99%

Irritable Bowel Syndrome

Mullin

Shepherd

Roland

et al. 2014

J Parenter Enteral Nutr

View full text Add to dashboard Cite

Irritable bowel syndrome is a complex disorder whose pathophysiology involves alterations in the enteric microbiota, visceral hypersensitivity, gut immune/barrier function, hypothalamic-pituitary-adrenal axis regulation, neurotransmitters, stress response, psychological factors, and more. The importance of diet in the management of irritable bowel syndrome has taken center stage in recent times as the literature validates the relationship of certain foods with the provocation of symptoms. Likewise, a number of elimination dietary programs have been successful in alleviating irritable bowel syndrome symptoms. Knowledge of the dietary management strategies for irritable bowel syndrome will help guide nutritionists and healthcare practitioners to deliver optimal outcomes. This tutorial reviews the nutrition management strategies for irritable bowel syndrome.

show abstract

“…Substantial evidence has indicated the implication of complementary and alternative medicines in the treatment of GIT diseases [13–16], among which many are used as dietary herbs. Accordingly, the dried rhizome of Atractylodis Rhizoma Macrocephalae (ARM, also known as Bai Zhu), Massa Medicata Fermentata (MMF), and Dolichoris Semen (DS), which are also employed in different dietary preparations in Asian countries, are being frequently used in various herbal formulations for the treatment of a number of GIT disorders in humans and animals [13, 14, 16].…”

Section: Introductionmentioning

confidence: 99%

“…A number of herbal formulas of traditional Japanese medicines (Kampo) as well as Chinese and Korean ones utilize mixtures of several herbs (multiherbs) in a single formula [13, 14, 16]. On the other hand, as the beneficial health effects of probiotics and their fermented food products are well known [27] including the prevention of diarrhea caused by antibiotics [28], we also used the mixed fermented/refermented extracts of the above three herbs in our experiment to judge whether our laboratory-fermented formulation in association with the probiotics employed would be advantageous over the corresponding laboratory-unfermented preparation in combating the adverse impact of neomycin.…”

Section: Introductionmentioning

confidence: 99%

Intestinal Protective Effects of Herbal-Based Formulations in Rats against Neomycin Insult

Bose

Han

Lee

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Disturbance in the gut microbial niche by antibiotics like neomycin produces gastrointestinal (GI) disorders. Here, we evaluated the impact of a mixture of extracts of three herbs (Atractylodis Rhizoma Macrocephalae, Massa Medicata Fermentata, and Dolichoris Semen) with known GI protective activities, either laboratory unfermented (herbal formulation-1 (HF-1)) or fermented/re-fermented (herbal formulation-2 (HF-2)) on neomycin-treated rats using a commercial Lactobacillus probiotic as a reference. Treatment with neomycin augmented stool water content, decreased fecal population of Lactobacillus spp., changed the histology of intestine without inducing inflammation, reduced the colonic expression of zonula occludens-1 (ZO-1) and claudin-1, and elevated the serum C-reactive protein (CRP) and interferon-gamma (IFN-γ) levels. Coadministration of either HF-2 or probiotic, but not HF-1, restored the fecal content of Lactobacillus spp., normalized the serum CRP level, and significantly increased the colonic expression of ZO-1 and claudin-1 in neomycin-treated rats. The combined treatment with any of the above agents ameliorated the histological changes of cecum and colon in neomycin-treated rats, and the magnitude of this effect was probiotic > HF-2 > HF-1. Our study revealed the intestinal protective effect of a mixture of three herbs against neomycin insult, which is mediated through multiple mechanisms and is potentiated upon prior fermentation/refermentation of the herbs.

show abstract

Tong-xie-ning, a Chinese herbal formula, in treatment of diarrhea-predominant irritable bowel syndrome: a prospective, randomized, double-blind, placebo-controlled trial

Cited by 24 publications

References 10 publications

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Irritable Bowel Syndrome

Intestinal Protective Effects of Herbal-Based Formulations in Rats against Neomycin Insult

Contact Info

Product

Resources

About