Tone Abnormalities Are Associated With Maternal Cigarette Smoking During Pregnancy in In Utero Cocaine-Exposed Infants

Da, Dempsey; Bl, Hajnal; Partridge, JC; Sn, Jacobson; Good, William V.; Rt, Jones; Dm, Ferriero

doi:10.1542/peds.106.1.79

Cited by 43 publications

(31 citation statements)

References 35 publications

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“…We reported similar dose-response associations with hypertonia and postural abnormalities in newborns (30), but in those analyses we were limited in our ability to control for cigarette exposure with biomarkers, which others have linked to hypertonia (32). Beyond the neonatal period Hurt et al report no neurological findings associated with prenatal cocaine exposure in 30 month-old infants (10) while Belcher et al described similar postural anomalies in this age group (29).…”

Section: Discussionmentioning

confidence: 55%

“…Other have described muscle tone abnormalities, hypertonia in particular, among cocaine-exposed infants and toddlers (27;27-31). We described hypertonia among infants at risk for HIV with cocaine exposure that resolved by 24 months (28), but were unable to control for confounding exposures, especially tobacco exposure, which has been linked to hypertonus (32).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prenatal cocaine exposures and dose-related cocaine effects on infant tone and behavior

Chiriboga

Kuhn

Wasserman

2007

Neurotoxicology and Teratology

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Prenatal cocaine exposures and dose-related cocaine effects on infant tone and behavior

Chiriboga

Kuhn

Wasserman

2007

Neurotoxicology and Teratology

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“…The AAP clinical report on neonatal drug withdrawal contains in-depth information on neonatal drug withdrawal, including treatment options. 155 Neurobehavior Abnormalities of newborn neurobehavior, including impaired orientation and autonomic regulation 156 and abnormalities of muscle tone, 144,147,157 have been identified in a number of prenatal nicotine exposure studies. Poor habituation and low levels of arousal along with motor abnormalities have been identified in women who drank alcohol heavily during their pregnancy.…”

Section: Withdrawalmentioning

confidence: 99%

Prenatal Substance Abuse: Short- and Long-term Effects on the Exposed Fetus

Behnke¹,

Levy²,

Ammerman³

et al. 2013

Pediatrics

483

389

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Prenatal substance abuse continues to be a significant problem in this country and poses important health risks for the developing fetus. The primary care pediatrician’s role in addressing prenatal substance exposure includes prevention, identification of exposure, recognition of medical issues for the exposed newborn infant, protection of the infant, and follow-up of the exposed infant. This report will provide information for the most common drugs involved in prenatal exposure: nicotine, alcohol, marijuana, opiates, cocaine, and methamphetamine.

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“…Resulta interesante señalar, una vez más, la dificultad de separar los efectos debidos a diferentes sustancias; aunque la hipertonía muscular es, del mismo modo que la microcefalia, un hallazgo frecuente en neonatos expuestos a cocaína, dicho podría deberse al uso concomitante de otras sustancias (en este caso, tabaco) a lo largo del embarazo 43 .…”

Section: Psicoestimulantesunclassified

Maternidad, infancia y drogas: implicaciones clínicas

Botella¹

2004

Adicciones

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RESUMENObjetivos: Revisar la relación entre la exposición prenatal a drogas y el pronóstico fetal, neonatal e infantil. Material y méto-dos: se estudia el estado actual de la investigación relativa a la exposición prenatal a sustancias psicoactivas, mediante una extensa revisión de Medline y de las investigaciones de organismos norteamericanas y europeos durante los últimos años. Se presta especial atención a las dificultades metodológicas derivadas del objeto de estudio y a otros factores tales como la relación materno-infantil y las características de la mujer adicta. Resultados: la exposición prenatal a drogas se asocial a un amplio rango de complicaciones obstétricas y alteraciones neuroconductuales infantiles. Con la excepción del síndrome alcohólico fetal y otros efectos fetales ligados al alcohol, estas alteraciones suelen encontrarse en dominios cognitivos específicos y pueden estar moduladas por factores psicosociales y ambientales. Conclusiones: los niños expuestos prenatalmente a drogas pueden ser considerados un caso especial de infancia en riesgo. Es necesario investigar el impacto real de la exposición prenatal a sustancias psicoactivas y la relevancia de otros factores en su pronóstico a medio y largo plazo. Asimismo, es necesario implicar y formar a diferentes profesionales, tales como obstetras, ginecólogos y pediatras, y coordinar la intervención de las diferentes instituciones, para mejorar la atención prestada a la mujer drogodependiente y a sus hijos.Palabras clave: mujer, droga, teratógeno, embarazo de alto riesgo, manifestaciones neuroconductuales.

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Tone Abnormalities Are Associated With Maternal Cigarette Smoking During Pregnancy in In Utero Cocaine-Exposed Infants

Abstract: Our findings suggest that maternal cigarette smoking may be the major predictor of tone abnormalities reported in cocaine-exposed infants.

Cited by 43 publications

References 35 publications

Prenatal cocaine exposures and dose-related cocaine effects on infant tone and behavior

Prenatal cocaine exposures and dose-related cocaine effects on infant tone and behavior

Prenatal Substance Abuse: Short- and Long-term Effects on the Exposed Fetus

Maternidad, infancia y drogas: implicaciones clínicas

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