Tomographic Dual Modality Breast Scanner

Williams, Mark B.; Judy, Patricia G.; Moré, M.J.; Harvey, Jennifer A.; Majewski, S.; Proffitt, James; McKisson, J.; Stolin, Alexander; Kross, B.; Stewart, Alex; Bullard, Edward; Kankaria, Manish; Janer, Roman

doi:10.1007/978-3-540-70538-3_15

Cited by 6 publications

(1 citation statement)

References 22 publications

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“…145,146 The combination of morphological information with functional information is also being developed by a group that is investigating combining DBT with limited angle Tc-99m sestamibi-based single photon emission computed tomography (SPECT). [147][148][149] The preliminary patient study performed showed that adding the functional information can improve the performance of DBT, especially in improving specificity. 149 Finally, DBT combined with diffuse optical tomography for interrogation of the hemoglobin and oxygen saturation state has been also investigated, with the optical characteristics of malignant lesions having been found to be different than benign lesions and normal tissues.…”

Section: Ivd Multimodality Imagingmentioning

confidence: 99%

A review of breast tomosynthesis. Part II. Image reconstruction, processing and analysis, and advanced applications

2013

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Many important post-acquisition aspects of breast tomosynthesis imaging can impact its clinical performance. Chief among them is the reconstruction algorithm that generates the representation of the three-dimensional breast volume from the acquired projections. But even after reconstruction, additional processes, such as artifact reduction algorithms, computer aided detection and diagnosis, among others, can also impact the performance of breast tomosynthesis in the clinical realm. In this two part paper, a review of breast tomosynthesis research is performed, with an emphasis on its medical physics aspects. In the companion paper, the first part of this review, the research performed relevant to the image acquisition process is examined. This second part will review the research on the post-acquisition aspects, including reconstruction, image processing, and analysis, as well as the advanced applications being investigated for breast tomosynthesis.

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Section: Ivd Multimodality Imagingmentioning

confidence: 99%

A review of breast tomosynthesis. Part II. Image reconstruction, processing and analysis, and advanced applications

2013

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DNA-Scaffolded Proximity Assembly and Confinement of Multienzyme Reactions

Wang

Liang

et al. 2020

Top Curr Chem (Z)

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Cellular functions rely on a series of organized and regulated multienzyme cascade reactions. The catalytic efficiencies of these cascades depend on the precise spatial organization of the constituent enzymes, which is optimized to facilitate substrate transport and regulate activities. Mimicry of this organization in a non-living, artificial system would be very useful in a broad range of applications-with impacts on both the scientific community and society at large. Self-assembled DNA nanostructures are promising applications to organize biomolecular components into prescribed, multidimensional patterns. In this review, we focus on recent progress in the field of DNA-scaffolded assembly and confinement of multienzyme reactions. DNA self-assembly is exploited to build spatially organized multienzyme cascades with control over their relative distance, substrate diffusion paths, compartmentalization and activity actuation. The combination of addressable DNA assembly and multienzyme cascades can deliver breakthroughs toward the engineering of novel synthetic and biomimetic reactors.

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Experimental and simulation studies for the optimization of dedicated scintimammography cameras

et al. 2012

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The main drawback of scintimammography with conventional gamma cameras is the large distance between detector and breast, which limits imaging performance and adds significant background noise from the heart and other organs. These limitations can be minimized by dedicated gamma cameras placed in tight contact with the breast. The purpose of this study was to determine the lowest Tumor-to-Background (T:B) ratio for detectable lesions and the smallest lesions that can be imaged with a dedicated system. The system is based on an R3292 position sensitive photomultiplier tube (PSPMT) from Hamamatsu, coupled to a 10 cm in diameter CsI(Tl) crystal and a general purpose collimator with hexagonal holes. Two crystals were assessed, with pixel size of 2 × 2 mm 2 and 3 × 3 mm 2 . The experimental setup consists of a cylindrical breast phantom, cylindrical tumor phantoms positioned inside the breast phantom at various depths, and a heart phantom. The same setup, as well as some additional tumor phantoms, were modeled with the GATE simulation toolkit, following the validation of the entire system. A 20% energy window and the Dual Energy Window Subtraction Method (DEWSM) for scatter correction were applied in experimental and simulation data. In all measurements 99m Tc was used. Signal to Noise Ratio (SNR) and contrast were measured in all experiments and used for quantification of results. Experimental and simulation results show that the lowest T:B ratio that can be detected is 2:1 with tumor phantom volume ≥ 0.25 ml at 1 cm depth. The smallest volume of a tumor phantom that can be detected is 0.04 ml with T:B ratio equal to 9:1 at 1 cm depth.

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Tomographic Dual Modality Breast Scanner

Cited by 6 publications

References 22 publications

A review of breast tomosynthesis. Part II. Image reconstruction, processing and analysis, and advanced applications

A review of breast tomosynthesis. Part II. Image reconstruction, processing and analysis, and advanced applications

DNA-Scaffolded Proximity Assembly and Confinement of Multienzyme Reactions

Experimental and simulation studies for the optimization of dedicated scintimammography cameras

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