Tomographic diffractive microscopy: basics, techniques and perspectives

Haeberlé, Olivier; Belkebir, Kamal; Giovaninni, H.; Sentenac, Anne

doi:10.1080/09500340.2010.493622

Cited by 158 publications

(151 citation statements)

References 89 publications

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“…2. A detailed explanation of its construction can be found in [12,20]. The lateral extension is twice that of holographic microscopy [12], but the most noticeable feature is the now non-negligible extension along the optical axis, which permit a better discrimination along the optical axis [14].…”

Section: Tdm With Illumination Rotationmentioning

confidence: 99%

“…As a consequence, the resolution is improved by a factor 2, as explained in Refs. [12,20,21] and experimentally demonstrated in Ref. [15].…”

Section: Tdm With Illumination Rotationmentioning

confidence: 99%

“…[6][7][8][9] for an introduction to the basics of diffraction, and to Refs. [20,21], for a more detailed description of holographic and tomographic microscopy in the framework of the first order Born approximation. Figure 1 describes the principle of holographic diffractive microscopy in a transmission set-up, in two-dimensions for the sake of simplicity, and in the ( )-plane.…”

Section: Tdm With Illumination Rotationmentioning

confidence: 99%

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Improved and isotropic resolution in tomographic diffractive microscopy combining sample and illumination rotation

et al. 2011

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Abstract:Tomographic Diffractive Microscopy is a technique, which permits to image transparent living specimens in three dimensions without staining. It is commonly implemented in two configurations, by either rotating the sample illumination keeping the specimen fixed, or by rotating the sample using a fixed illumination. Under the first-order Born approximation, the volume of the frequency domain that can be mapped with the rotating illumination method has the shape of a "doughnut", which exhibits a so-called "missing cone" of non-captured frequencies, responsible for the strong resolution anisotropy characteristic of transmission microscopes. When rotating the sample, the resolution is almost isotropic, but the set of captured frequencies still exhibits a missing part, the shape of which resembles that of an apple core. Furthermore, its maximal extension is reduced compared to tomography with rotating illumination. We propose various configurations for tomographic diffractive microscopy, which combine both approaches, and aim at obtaining a high and isotropic resolution. We illustrate with simulations the expected imaging performances of these configurations. 42.30.-d, 42.40.-i, 42.90.+m PACS (2008):

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Section: Tdm With Illumination Rotationmentioning

confidence: 99%

“…As a consequence, the resolution is improved by a factor 2, as explained in Refs. [12,20,21] and experimentally demonstrated in Ref. [15].…”

Section: Tdm With Illumination Rotationmentioning

confidence: 99%

Section: Tdm With Illumination Rotationmentioning

confidence: 99%

See 1 more Smart Citation

Improved and isotropic resolution in tomographic diffractive microscopy combining sample and illumination rotation

et al. 2011

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“…4. In contrast to the backprojection case of is used and cap of spheres considering a 3-D representation [3,[5][6][7]. Experimentally, the wave scattered by a weakly scattering object can be recorded on the surface of an image sensor.…”

Section: Diffractive Optical Coherent Microtomographymentioning

confidence: 99%

“…Three-dimensional observation of weakly diffractive samples have, so far, been realized by varying the sample illumination with a fixed sample [3][4][5][6][7] or by rotating the sample using a fixed illumination [8][9][10][11][12]. In the sample illumination variation method, tomography is realized by varying the sample illumination angle in a range limited by the illumination system (usually a condenser) numerical aperture, drastically increasing the object spatial frequencies captured by this system in comparison to a conventional holographic transmission microscope, which uses only one direction of illumination.…”

Section: Introductionmentioning

confidence: 99%

Diffraction microtomography with sample rotation: influence of a missing apple core in the recorded frequency space

Vertu¹,

Delaunay²,

Yamada³

et al. 2009

Open Physics

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Abstract:Diffraction microtomography in coherent light is foreseen as a promising technique to image transparent living samples in three dimensions without staining. Contrary to conventional microscopy with incoherent light, which gives morphological information only, diffraction microtomography makes it possible to obtain the complex optical refractive index of the observed sample by mapping a three-dimensional support in the spatial frequency domain. The technique can be implemented in two configurations, namely, by varying the sample illumination with a fixed sample or by rotating the sample using a fixed illumination. In the literature, only the former method was described in detail. In this report, we precisely derive the three-dimensional frequency support that can be mapped by the sample rotation configuration. We found that, within the first-order Born approximation, the volume of the frequency domain that can be mapped exhibits a missing part, the shape of which resembles that of an apple core. The projection of the diffracted waves in the frequency space onto the set of sphere caps covered by the sample rotation does not allow for a complete mapping of the frequency along the axis of rotation due to the finite radius of the sphere caps. We present simulations of the effects of this missing information on the reconstruction of ideal objects. ; 42.30.-d; 42.40.-i; 42.90.+m PACS (2008): 42.

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