Tomentodione E, a new <i>sec</i>-pentyl syncarpic acid-based meroterpenoid from the leaves of <i>Rhodomyrtus tomentosa</i>

Liu, Jie; Song, Jian-Guo; Su, Jun-Cheng; Huang, Xiao‐Jun; Ye, Wen‐Cai; Wang, Ying

doi:10.1080/10286020.2017.1318852

Cited by 16 publications

(5 citation statements)

References 24 publications

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“…Likewise, various terpenoids such as taraxerol, betulin, botulin-3-acetate, 3 β -acetoxy-11 α -epoxyoleanan-28,13 β -olide, 3 β -acetoxy-12 α -hydroxyoleanan-28,13 β -olide, and 3 β -acetoxy-12-oxo-oleanan-28,13 β -olide were also identified in R. tomentosa stems [7,9]. Recently, numerous terpenoids were reported from R. tomentosa leaves, such as rhodomentones A and B [10], tomentosenol A, 4S-focifolidione, 4R-focifolidione [11], tomentodione E [12], rhodomyrtials A and B, tomentodiones A–D [13], tomentodiones E–G, and tomentodiones H-M [14], and from R. tomentosa root, such as tomentodiones H–M [15].…”

Section: Phytochemical Compositionmentioning

confidence: 99%

The Health Beneficial Properties of Rhodomyrtus tomentosa as Potential Functional Food

Ngo

2019

Biomolecules

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Rhodomyrtus tomentosa (Aiton) Hassk. is a flowering plant belonging to the family Myrtaceae, native to southern and southeastern Asia. It has been used in traditional Vietnamese, Chinese, and Malaysian medicine for a long time for the treatment of diarrhea, dysentery, gynecopathy, stomachache, and wound healing. Moreover, R. tomentosa is used to make various food products such as wine, tea, and jam. Notably, R. tomentosa has been known to contain structurally diverse and biologically active metabolites, thus serving as a potential resource for exploring novel functional agents. Up to now, numerous phenolic and terpenoid compounds from the leaves, root, or fruits of R. tomentosa have been identified, and their biological activities such as antioxidant, antibacterial, anti-inflammatory, and anticancer have been evidenced. In this contribution, an overview of R. tomentosa and its health beneficial properties was focused on and emphasized.

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Section: Phytochemical Compositionmentioning

confidence: 99%

The Health Beneficial Properties of Rhodomyrtus tomentosa as Potential Functional Food

Ngo

2019

Biomolecules

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“…In addition, its fruits are one of the most popular foods in the wild. The vital medicinal and nutritional properties of R. tomentosa have drawn the attention of researchers in recent years [4,5]. The major chemical components of R. tomentosa include hydrolytic tannins, phloroglucin, flavonoids, and triterpenes [6], which possess antioxidant, anti-inflammatory, anti-tumor, antibacterial and other biological activities [7,8].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of Rhodomyrtus tomentosa Chloroplast Genome

Huang

Yang

Huang

et al. 2019

Plants

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In the last decade, several studies have relied on a small number of plastid genomes to deduce deep phylogenetic relationships in the species-rich Myrtaceae. Nevertheless, the plastome of Rhodomyrtus tomentosa, an important representative plant of the Rhodomyrtus (DC.) genera, has not yet been reported yet. Here, we sequenced and analyzed the complete chloroplast (CP) genome of R. tomentosa, which is a 156,129-bp-long circular molecule with 37.1% GC content. This CP genome displays a typical quadripartite structure with two inverted repeats (IRa and IRb), of 25,824 bp each, that are separated by a small single copy region (SSC, 18,183 bp) and one large single copy region (LSC, 86,298 bp). The CP genome encodes 129 genes, including 84 protein-coding genes, 37 tRNA genes, eight rRNA genes and three pseudogenes (ycf1, rps19, ndhF). A considerable number of protein-coding genes have a universal ATG start codon, except for psbL and ndhD. Premature termination codons (PTCs) were found in one protein-coding gene, namely atpE, which is rarely reported in the CP genome of plants. Phylogenetic analysis revealed that R. tomentosa has a sister relationship with Eugenia uniflora and Psidium guajava. In conclusion, this study identified unique characteristics of the R. tomentosa CP genome providing valuable information for further investigations on species identification and the phylogenetic evolution between R. tomentosa and related species.

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“…Myrtucommulones and related acylphloroglucinols from Myrtaceae were evaluated for their in vitro activity against the respiratory syncytial virus (RSV), showing promising effects compared with the ribavirin control. Studies suggested that the antiviral activity of these compounds might be influenced by the side chains of the phloroglucinol moiety [ 20 , 21 ]. Phloroglucinols have also been shown to be effective against other viruses, such as human immunodeficiency virus (HIV), herpes or enterovirus, and preliminary docking analysis data suggest that they can be effective against SARS-CoV-2 [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…Among these compounds, the myrtucommulones are related to various biological activities. Several have shown significant activities against Epstein–Barr virus (EBV), herpes simplex virus (HSV), respiratory syncytial virus (RSV), and human immunodeficiency virus (HIV), and more recently, docking analysis have suggested that they can be effective against SARS-CoV-2 [ 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Myrtucommulones and Related Acylphloroglucinols from Myrtaceae as a Promising Source of Multitarget SARS-CoV-2 Cycle Inhibitors

Mendonça,

Gomes,

Campos

et al. 2024

Pharmaceuticals

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The LABEXTRACT plant extract bank, featuring diverse members of the Myrtaceae family from Brazilian hot spot regions, provides a promising avenue for bioprospection. Given the pivotal roles of the Spike protein and 3CLpro and PLpro proteases in SARS-CoV-2 infection, this study delves into the correlations between the Myrtaceae species from the Atlantic Forest and these targets, as well as an antiviral activity through both in vitro and in silico analyses. The results uncovered notable inhibitory effects, with Eugenia prasina and E. mosenii standing out, while E. mosenii proved to be multitarget, presenting inhibition values above 72% in the three targets analyzed. All extracts inhibited viral replication in Calu-3 cells (EC50 was lower than 8.3 µg·mL−1). Chemometric analyses, through LC-MS/MS, encompassing prediction models and molecular networking, identified potential active compounds, such as myrtucommulones, described in the literature for their antiviral activity. Docking analyses showed that one undescribed myrtucommulone (m/z 841 [M − H]−) had a higher fitness score when interacting with the targets of this study, including ACE2, Spike, PLpro and 3CLpro of SARS-CoV-2. Also, the study concludes that Myrtaceae extracts, particularly from E. mosenii and E. prasina, exhibit promising inhibitory effects against crucial stages in SARS-CoV-2 infection. Compounds like myrtucommulones emerge as potential anti-SARS-CoV-2 agents, warranting further exploration.

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Tomentodione E, a new sec-pentyl syncarpic acid-based meroterpenoid from the leaves of Rhodomyrtus tomentosa

Cited by 16 publications

References 24 publications

The Health Beneficial Properties of Rhodomyrtus tomentosa as Potential Functional Food

The Health Beneficial Properties of Rhodomyrtus tomentosa as Potential Functional Food

Comprehensive Analysis of Rhodomyrtus tomentosa Chloroplast Genome

Myrtucommulones and Related Acylphloroglucinols from Myrtaceae as a Promising Source of Multitarget SARS-CoV-2 Cycle Inhibitors

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