Tomato Seed Extract Containing Lycoperoside H Improves Skin Elasticity in Japanese Female Subjects: A Randomized, Placebo-Controlled, Double-Blind Trial

Abstract

Background and Objective: Tomato seeds are edible seeds unconsciously ingested with the fruit. However, there are few reports regarding the constituents and biological activities of tomato seed extract (TSE). Recently, we found that saponins are major constituents of TSE including lycoperoside H. Previous reports have described that several plant-derived saponins improve skin diseases such as wounds and microangiopathy. Therefore, to discover the effect of TSE on the skin condition, we conducted a clinical trial of TSE (Tomato Seed Extract-P) standardized with lycoperoside H when orally ingested. Methods: The study was performed as a randomized, double-blind, placebo-controlled study. TSE (200 mg daily) containing 1 mg of lycoperoside H was used as the active sample. We enrolled 44 Japanese women who have concerns about facial elasticity and relatively low facial skin elasticity. All subjects were randomly allocated into either the active group (n = 22) or the placebo group (n = 22) using a computerized random-number generator. Capsules containing either the active sample or a placebo were administered for 8 weeks between October 12, 2020, and January 16, 2021. Facial elasticity, specifically the R7 value, was evaluated as the primary outcome. The remaining facial R parameters, upper arm R parameters, and other skin parameters including epidermal moisture, trans epidermal water loss, dermal parameters, and advanced glycation end products (AGEs) parameters were measured at 0, 4, and 8 weeks of ingestion. Blood, urine, and body parameters were also evaluated for safety. Results: Forty-three subjects completed the trial,

Mastering health: liberating beauty

“…According to D. Masterson (2021) the flagships of the moment include Biotin and marine collagen, with a mixture derived from seaweed for the treatment of the hair; extracts of apple; nettle accompanied by Shatavari for the treatment of thinning hair root in women in the postpartum phase; lemon verbena extracts and rosemary with olive leaves and Japanese sophora to treat wrinkles and oxidative stress, collagen from the eggshell membrane, to help maintain the softness and elasticity of the skin, and trans‐resveratrol isolated from Japanese knotweed extract to strengthen the body's production of antioxidants. More recently, saponins which are major components of tomato seed extract, were reported to improve skin diseases and maintain skin elasticity (Izumi et al 2021).…”

Lycoperoside H protects against diabetic nephropathy via alteration of gut microbiota and inflammation

“…[ 21,22 ] Lycoperoside H (LH) is a well‐known alkaloidal saponin and active ingredient of tomatoes. [ 22–24 ] The activity of the LH is similar to the other alkaloidal saponin such as esculeosides and lycoperosides. Saponins already show various biological activities such as wound healing and anti‐inflammatory effect.…”

“…Saponins already show various biological activities such as wound healing and anti-inflammatory effect. [21][22][23] Still nephroprotective effect of LH is still unexplored. Due to the antiinflammatory effect, in this experimental study, we make effort to scrutinize the renal protective effect of LH against streptozotocin (STZ)-induced DN rats.…”