Tomato
            <i>Ve</i>
            disease resistance genes encode cell surface-like receptors

Kawchuk, L. M.; Hachey, John; Lynch, D. R.; Kulcsar, F.; Rooijen, Gijs van; Waterer, D.; Robertson, A.J.; Kokko, Eric; Byers, Richard; Howard, R. J.; Fischer, Rainer; Prüfer, Dirk

doi:10.1073/pnas.091114198

Cited by 429 publications

(393 citation statements)

References 39 publications

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“…Resistance loci 'to the North' of Rpi-phu1 are Tm-2a from Solanum peruvianum conferring resistance to Tomato mosaic virus (Tanksley et al 1992), Fr1 for tomato resistance to Fusarium oxysporum f. sp. radicis-lycopersici (Zhang et al 2003) and Ve1 for resistance to Verticillium dahliae in tomato and potato (Kawchuk et al 2001;Simko et al 2004). …”

Section: Discussionmentioning

confidence: 99%

The novel, major locus Rpi-phu1 for late blight resistance maps to potato chromosome IX and is not correlated with long vegetation period

et al. 2006

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Despite the long history of breeding potatoes resistant to Phytophthora infestans, this oomycete is still economically the most important pathogen of potato worldwide. The correlation of high levels of resistance to late blight with a long vegetation period is one of the bottlenecks for progress in breeding resistant cultivars of various maturity types. Solanum phureja was identiWed as a source of eVective late blight resistance, which was transferred to the cultivated gene pool by interspeciWc crosses with dihaploids of Solanum tuberosum. A novel major resistance locus, Rpiphu1, derived most likely from S. phureja and conferring broad-spectrum resistance to late blight, was mapped to potato chromosome IX, 6.4 cM proximal to the marker GP94. Rpi-phu1 was highly eVective in detached leaXet, tuber slice and whole tuber tests during 5 years of quantitative phenotypic assessment. The resistance did not show signiWcant correlation with vegetation period length. Our Wndings provide a well-characterized new source of resistance for breeding early and resistant-to-P. infestans potatoes.

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Section: Discussionmentioning

confidence: 99%

The novel, major locus Rpi-phu1 for late blight resistance maps to potato chromosome IX and is not correlated with long vegetation period

et al. 2006

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“…A small number of RLPs, such as the tomato (Solanum lycopersicum) Cf and Ve proteins and the apple (Malus domestica) HcrVf2 protein, were shown to function as R proteins (Jones et al, 1994;Kawchuk et al, 2001;Belfanti et al, 2004;Fradin et al, 2009). Interestingly, Ve1-mediated resistance to Verticillium requires BAK1 (Fradin et al, 2009(Fradin et al, , 2011.…”

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confidence: 99%

The Ankyrin-Repeat Transmembrane Protein BDA1 Functions Downstream of the Receptor-Like Protein SNC2 to Regulate Plant Immunity

et al. 2012

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Plants utilize a large number of immune receptors to recognize pathogens and activate defense responses. A small number of these receptors belong to the receptor-like protein family. Previously, we showed that a gain-of-function mutation in the receptor-like protein SNC2 (for Suppressor of NPR1, Constitutive2) leads to constitutive activation of defense responses in snc2-1D mutant plants. To identify defense signaling components downstream of SNC2, we carried out a suppressor screen in the snc2-1D mutant background of Arabidopsis (Arabidopsis thaliana). Map-based cloning of one of the suppressor genes, BDA1 (for bian da; "becoming big" in Chinese), showed that it encodes a protein with amino-terminal ankyrin repeats and carboxylterminal transmembrane domains. Loss-of-function mutations in BDA1 suppress the dwarf morphology and constitutive defense responses in snc2-1D npr1-1 (for nonexpressor of pathogenesis-related genes1,1) and also result in enhanced susceptibility to bacterial pathogens. In contrast, a gain-of-function allele of bda1 isolated from a separate genetic screen to search for mutants with enhanced pathogen resistance was found to constitutively activate cell death and defense responses. These data suggest that BDA1 is a critical signaling component that functions downstream of SNC2 to regulate plant immunity.

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“…Amino acid substitutions of the YXXF motif eliminate polar localization of the Arabidopsis boron transporter REQUIRES HIGH BORON1 in the plasma membrane of root tip cells (Takano et al, 2010). The YXXF motif is also present in the cytoplasmic domain of the following two leucine-rich repeat proteins involved in the plant immune response to pathogens: Ve2, which is involved in fungal race-specific resistance in tomato (Solanum lycopersicum) (Kawchuk et al, 2001), and EFR, which is a leucine-rich repeat receptor for bacterial elongation factor EF-Tu (Zipfel et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Identification and Dynamics of Arabidopsis Adaptor Protein-2 Complex and Its Involvement in Floral Organ Development

et al. 2013

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ORCID ID: 0000-0003-4154-9967 (S.Y.).The adaptor protein-2 (AP-2) complex is a heterotetramer involved in clathrin-mediated endocytosis of cargo proteins from the plasma membrane in animal cells. The homologous genes of AP-2 subunits are present in the genomes of plants; however, their identities and roles in endocytic pathways are not clearly defined in plants. Here, we reveal the molecular composition of the AP-2 complex of Arabidopsis thaliana and its dynamics on the plasma membrane. We identified all of the a-, b-, s-, and m-subunits of the AP-2 complex and detected a weak interaction of the AP-2 complex with clathrin heavy chain. The m-subunit protein fused to green fluorescent protein (AP2M-GFP) was localized to the plasma membrane and to the cytoplasm. Live-cell imaging using a variable-angle epifluorescence microscope revealed that AP2M-GFP transiently forms punctate structures on the plasma membrane. Homozygous ap2m mutant plants exhibited abnormal floral structures, including reduced stamen elongation and delayed anther dehiscence, which led to a failure of pollination and a subsequent reduction of fertility. Our study provides a molecular basis for understanding AP-2-dependent endocytic pathways in plants and their roles in floral organ development and plant reproduction.

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Tomato Ve disease resistance genes encode cell surface-like receptors

Abstract: In tomato, Ve is implicated in race-specific resistance to infection by

Cited by 429 publications

References 39 publications

The novel, major locus Rpi-phu1 for late blight resistance maps to potato chromosome IX and is not correlated with long vegetation period

The novel, major locus Rpi-phu1 for late blight resistance maps to potato chromosome IX and is not correlated with long vegetation period

The Ankyrin-Repeat Transmembrane Protein BDA1 Functions Downstream of the Receptor-Like Protein SNC2 to Regulate Plant Immunity

Identification and Dynamics of Arabidopsis Adaptor Protein-2 Complex and Its Involvement in Floral Organ Development

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