Tomatidine provides mitophagy‐independent neuroprotection after ischemic injury

Wang, Yuting; Zhang, Lina; Lyu, Xiao-cui; Li, Yue; Ahsan, Anil; Feng, Zikai; Zhang, Xiangnan

doi:10.1002/2211-5463.13265

Cited by 7 publications

(2 citation statements)

References 24 publications

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“…Kshirsagar published a second time a year later, this time using the amyloid precursor protein (APP) as a transfect for HT-22 cells (APP-HT22) [ 57 ]. Results are quite similar to the previously described article [ 56 ] albeit that TO (10µM) did not enhance the survival of APP-HT22 cells.…”

Section: Therapeutic Context— Solanum S(g)asmentioning

confidence: 99%

The Therapeutic Value of Solanum Steroidal (Glyco)Alkaloids: A 10-Year Comprehensive Review

et al. 2023

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Steroidal (glycol)alkaloids S(G)As are secondary metabolites made of a nitrogen-containing steroidal skeleton linked to a (poly)saccharide, naturally occurring in the members of the Solanaceae and Liliaceae plant families. The genus Solanum is familiar to all of us as a food source (tomato, potato, eggplant), but a few populations have also made it part of their ethnobotany for their medicinal properties. The recent development of the isolation, purification and analysis techniques have shed light on the structural diversity among the SGAs family, thus attracting scientists to investigate their various pharmacological properties. This review aims to overview the recent literature (2012–2022) on the pharmacological benefits displayed by the SGAs family. Over 17 different potential therapeutic applications (antibiotic, antiviral, anti-inflammatory, etc.) were reported over the past ten years, and this unique review analyzes each pharmacological effect independently without discrimination of either the SGA’s chemical identity or their sources. A strong emphasis is placed on the discovery of their biological targets and the subsequent cellular mechanisms, discussing in vitro to in vivo biological data. The therapeutic value and the challenges of the solanum steroidal glycoalkaloid family is debated to provide new insights for future research towards clinical development.

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Section: Therapeutic Context— Solanum S(g)asmentioning

confidence: 99%

The Therapeutic Value of Solanum Steroidal (Glyco)Alkaloids: A 10-Year Comprehensive Review

et al. 2023

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“…Studies have shown that tomatidine has a variety of health effects, such as anti-in ammatory, anti-atherosclerotic, and antibacterial 10 . Tomatidine has been reported to inhibit cancer cell growth 11 , and tomatidine can induce autophagy in damaged cells 12 . A number of studies have shown that tomatidine, an abundant steroidal alkaloid in Solanaceae, has pro-autophagy biological activity in vitro and in vivo for a variety of species.…”

Section: Introductionmentioning

confidence: 99%

Tomatidine improves liver fibrosis by promoting autophagy in hepatic stellate cells through the ERK/MAPK-mTOR-ULK1 pathway

Shen

Tang

et al. 2023

Preprint

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Liver fibrosis is caused by various liver diseases and eventually develops into liver cancer. Tomatidine (TD), an aglycone of α-tomatidine, is a major glycoalkaloid found in immature tomato fruits, leaves, and stems. In this study, we investigated that tomatidine may promote autophagy in hepatic stellate cells through the ERK/MAPK-mTOR-ULK1 signaling pathway to improve liver fibrosis and combined experimental validation and molecular docking to reveal the underlying mechanism. First, we found that tomatidine could inhibit the proliferation of hepatic stellate cells and the expression of fibrosis-related proteins α-smooth muscle actin (α-SMA) and collagen type I 1 gene (COL1A1) in LX2 cells. Tomatidine was found to promote the expression of autophagy-related proteins. Next, we performed a network pharmacology screen and found that among the targets of tomatidine and the common targets of tomatidine and liver fibrosis, no target related to autophagy was found in the current database. However, pharmacological studies of tomatidine have confirmed the existence of pro-autophagy pharmacological effects. Therefore, we used molecular docking to verify that tomatidine had good binding and affinity with autophagy-related targets. Further network pharmacological analysis showed that the MAPK signaling pathway may be involved in the biological process of tomatidine against hepatic stellate cells. We further verified the ERK/MAPK-mTOR-ULK1 pathway and found that tomatidine could promote autophagy in LX-2 cells by inhibiting the expression of P-ERK and P-mTOR and activating the expression of P-ULK1. Finally, molecular docking was performed to reveal the binding of tomatidine to the active sites of ERK, MAPK, mTOR, and ULK1.

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Tomatidine activates autophagy to improve lung injury and inflammation in sepsis by inhibiting NF-κB and MAPK pathways

Xu,

Huang,

et al. 2024

Mol Genet Genomics

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Tomatidine provides mitophagy‐independent neuroprotection after ischemic injury

Cited by 7 publications

References 24 publications

The Therapeutic Value of Solanum Steroidal (Glyco)Alkaloids: A 10-Year Comprehensive Review

The Therapeutic Value of Solanum Steroidal (Glyco)Alkaloids: A 10-Year Comprehensive Review

Tomatidine improves liver fibrosis by promoting autophagy in hepatic stellate cells through the ERK/MAPK-mTOR-ULK1 pathway

Tomatidine activates autophagy to improve lung injury and inflammation in sepsis by inhibiting NF-κB and MAPK pathways

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