1997
DOI: 10.1006/taap.1996.8059
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Toluene Disrupts Outer Hair Cell Morphometry and Intracellular Calcium Homeostasis in Cochlear Cells of Guinea Pigs

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Cited by 24 publications
(3 citation statements)
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“…Toluene is an ototoxic organic solvent that increases free intracellular calcium levels in the spiral ganglion and the outer hair cells 16) . Although its action focuses preferently o n c o c h l e a r m i d d l e a n d m i d -a p i c a l t u r n s 1 7 ) , electrocochleographic recording of auditory evoked potentials from the round window show a hearing deficit also in the mid-low frequency region in rats, after toluene exposure 18) .…”
Section: Discussionmentioning
confidence: 99%
“…Toluene is an ototoxic organic solvent that increases free intracellular calcium levels in the spiral ganglion and the outer hair cells 16) . Although its action focuses preferently o n c o c h l e a r m i d d l e a n d m i d -a p i c a l t u r n s 1 7 ) , electrocochleographic recording of auditory evoked potentials from the round window show a hearing deficit also in the mid-low frequency region in rats, after toluene exposure 18) .…”
Section: Discussionmentioning
confidence: 99%
“…While this auditory impairment was recorded in laboratory animals at high toluene exposures as compared to permissible exposure levels (205), Liu and Fechter (206) demonstrated that the toxic effect in cochlear cells can be observed in vitro at toluene concentrations that are more realistic for human occupational exposure. Finally, effects on the thyroid gland (mild reduction of follide size) have been reported after toluene inhalation in female rats (207).…”
Section: Alkylbenzenes: Toluene and Xylenementioning
confidence: 93%
“…In response to sound stimulation, Ca 2+ influx and Ca 2+ -induced Ca 2+ release (CICR) from the endoplasmic reticulum significantly increase intracellular Ca 2+ in cochlear sensory cells. Factors that cause hearing impairment, such as ototoxic drugs, acoustic overstimulation, and aging, are associated with dysregulation of Ca 2+ homeostasis (Fridberger & Ulfendahl, 1996; Kidd Iii & Bao, 2012; Liu & Fechter, 1997; Richard et al, 2023). Two types of specialized sensory cells in the mammalian cochlea, inner hair cells (IHCs) and outer hair cells (OHCs), are involved in the transduction of sound into electrical responses (Dallos, 1992).…”
Section: Introductionmentioning
confidence: 99%