Toluene diisocyanate enhances human bronchial epithelial cells' permeability partly through the vascular endothelial growth factor pathway

Zhao, Haijin; Peng, Hong‐Juan; Sx, Cai; Li, W.; Zou, Fangdong; Tong, Wan-cheng

doi:10.1111/j.1365-2222.2009.03300.x

Cited by 20 publications

(10 citation statements)

References 30 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Blocking VEGF signaling with VEGFR inhibitors reduced AHR and inflammation induced by TDI in a murine model . And we found increased expression of VEGF induced by TDI–HSA conjugate in our previous study . These studies suggest that VEGF is one of the major determinants of TDI‐induced asthma.…”

Section: Discussionsupporting

confidence: 90%

Blockade of β-catenin signaling attenuates toluene diisocyanate-induced experimental asthma

Yao

Zhao

Tang

et al. 2016

Allergy

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

Blockade of β-catenin signaling attenuates toluene diisocyanate-induced experimental asthma

Yao

Zhao

Tang

et al. 2016

Allergy

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Basic Science Researchmentioning

confidence: 99%

“…Airway epithelia in asthmatics, especially in severe disease, exhibited disruption of tight junctions and increased permeability, while the mechanisms of this epithelial barrier dysfunction remain unclear. Zhao et al 51 reported that toluene diisocyanate, a well-recognized chemical asthmogen, significantly increased the permeability of human bronchial epithelial cell monolayer. This epithelial dysfunction was associated with a marked release of vascular endothelial growth factor, and vascular endothelial growth factor-neutralizing antibody could significantly lower the permeability.…”

Section: Mechanisms Related To Airway Epithelial Function and Damagementioning

confidence: 99%

Asthma research in China: A five‐year review

2013

View full text Add to dashboard Cite

Asthma is one of the most common chronic diseases worldwide with increasing morbidity. China has the largest asthmatic population and is one of the countries with the highest asthma mortality. Fortunately, asthma research in China, both clinical and scientific, has developed markedly over the past few years. This has resulted in significant increases in our understanding of Chinese asthma prevalence, risk factors, control status, pathogenesis, and new prevention or treatment strategies. In this review, the major achievements of asthma research in China from 2008 to 2012 are summarized.

show abstract

“…The mechanism of sensitization is controversial because specific IgE antibodies against isocyanates are found in a minority of subjects with asthma. Isocyanates may directly damage airway epithelium through a GSH-dependent mechanism [32] and increase the permeability of bronchial epithelium through a VEGF-mediated pathway in vitro [33]. Occupational exposure to isocyanates enhances spontaneous IL-10 production by peripheral blood mononuclear cells (PBMC) [34].…”

Section: Occupational Asthmamentioning

confidence: 99%

Developments in the field of allergy in 2009 through the eyes of Clinical and Experimental Allergy

Chu¹,

Lloyd²,

Karmaus³

et al. 2010

Clin Experimental Allergy

View full text Add to dashboard Cite

In 2009 the journal published in the region of 200 papers including reviews, editorials, opinion pieces and original papers that ran the full gamut of allergic disease. It is instructive to take stock of this output to determine patterns of interest and where the cutting edge lies. We have surveyed the field of allergic disease as seen through the pages of Clinical and Experimental Allergy (CEA) highlighting trends, emphasizing notable observations and placing discoveries in the context of other key papers published during the year. The review is divided into similar sections as the journal. In the field of Asthma and Rhinitis CEA has contributed significantly to the debate about asthma phenotypes and expressed opinions about the cause of intrinsic asthma. It has also added its halfpennyworth to the hunt for meaningful biomarkers. In Mechanisms the considerable interest in T cell subsets including Th17 and T regulatory cells continues apace and the discipline of Epidemiology continues to invoke a steady stream of papers on risk factors for asthma with investigators still trying to explain the post-second world war epidemic of allergic disease. Experimental Models continue to make important contributions to our understanding of pathogenesis of allergic disease and in the Clinical Allergy section various angles on immunotherapy are explored. New allergens continue to be described in the allergens section to make those allergen chips even more complicated. A rich and vibrant year helpfully summarized by some of our associate editors.

show abstract

Toluene diisocyanate enhances human bronchial epithelial cells' permeability partly through the vascular endothelial growth factor pathway

Abstract: TDI increases the permeability of HBE cell monolayers, partly through a VEGF-mediated pathway. This suggests the importance of VEGF in TDI-induced pulmonary diseases, but shows that other pathways may be involved in the pathogenic process.

Cited by 20 publications

References 30 publications

Blockade of β-catenin signaling attenuates toluene diisocyanate-induced experimental asthma

Blockade of β-catenin signaling attenuates toluene diisocyanate-induced experimental asthma

Asthma research in China: A five‐year review

Developments in the field of allergy in 2009 through the eyes of Clinical and Experimental Allergy

Contact Info

Product

Resources

About