Toluene concentrations in the blood and risk of thyroid cancer among residents living near national industrial complexes in South Korea: A population-based cohort study

Kim, Seyoung; Park, Eun-Jung; Song, Sanghwan; Lee, Chul-Woo; Kwon, Jung-Taek; Kim, Byungmi

doi:10.1016/j.envint.2020.106304

Cited by 21 publications

(10 citation statements)

References 29 publications

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“…However, higher concentration of butan-2-one was reported in human blood and urine samples collected from patients with liver cancer [45] and breast cancer [14], respectively. Similarly, benzene [46], toluene [47] and styrene [48] have been classified as potential carcinogens, indicating that these molecules may be closely associated with disease conditions as well. Therefore, a baseline study confirming the presence of these molecules in healthy human blood is critical to monitor the concentration of these compounds in disease conditions.…”

Section: Discussionmentioning

confidence: 99%

Profiling volatile organic compounds from human plasma using GC × GC-ToFMS

et al. 2023

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Volatile organic compounds (VOCs) originating from human metabolic activities can be detected in, for example, breath, urine, feces, and blood. Thus, attention has been given to identifying VOCs from the above matrices. Studies identifying and measuring human blood VOCs are limited to those focusing on monitoring specific pollutants, or blood storage and/or decomposition. However, a comprehensive characterization of VOCs in human blood collected for routine diagnostic testing is lacking. In this study, 72 blood-derived plasma samples were obtained from apparently healthy adult participants. VOCs were extracted from plasma using solid-phase microextraction and analyzed using comprehensive two-dimensional gas chromatography tandem time-of-flight mass spectrometry (GC×GC-ToFMS). Chromatographic data were aligned, and putative compound identities were assigned via spectral library comparison. All statistical analysis, including contaminant removal, data normalization and transformation were performed using R. We identified 401 features which we called the pan volatilome of human plasma. Of the 401 features, 34 were present in all the samples with less than 15% variance (core molecules), 210 were present in ≥10% but <100% of the samples (accessory molecules) and 157 were present in less than 10% of the samples (rare molecules). The core molecules, consisting of aliphatic, aromatic and carbonyl compounds were validated using 25 additional samples. The validation accuracy was 99.9%. Of the 34 core molecules, two molecules (octan-2-one and 4-methylheptane) have been identified from the plasma samples for the first time. Overall, our data describes the baseline VOC profile in human plasma and will serve as a resource for blood-derived VOCs that can complement future biomarker studies using different matrices.

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Section: Discussionmentioning

confidence: 99%

Profiling volatile organic compounds from human plasma using GC × GC-ToFMS

et al. 2023

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“…Moreover, some epidemiological studies have demonstrated the presence of risk of central nervous system symptoms with blood benzene concentrations as low as 0.19 ng/mL, peripheral nervous system symptoms with blood toluene as low as 0.49 ng/mL, 68 and thyroid cancer with blood toluene as low as 0.63 ng/mL. 69 Therefore, at the policy level, our study supports (1) a mandate of wearing personal protective equipment while performing high exposure tasks such as laying asphalt, and enforcement of this policy as part of safety management on the job site; as well as (2) regular monitoring of VOC biomarkers among construction workers to inform work rotations. A major strength of this study was the use of a large nationally representative sample, which allowed us to translate the findings to the general population in the United States.…”

Section: Figure 2 Spearman Correlation Of the Five Btex Among Us Workersmentioning

confidence: 99%

Blood Concentrations of Volatile Organic Compounds Among US Workers From Various Trades

Zhang

Lan

Bao

et al. 2023

J Occup Environ Med

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The presumed high exposure to volatile organic compounds among construction workers has not been substantiated with biomonitoring evidence. This study found that construction occupation was associated with increased blood concentrations of toluene, ethylbenzene, o-xylene, and m-/p- xylene. The findings inform interventions for exposure reduction using engineering controls and personal protective equipment.

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“…Adolescents are vulnerable to environmental pollutants, and high school students in Korea frequently spend 14 hours or more per day at school [26]. As there previously have been continuous exposures to odors in this area, it is necessary to continuously identify and update potential health risks through the establishment of a cohort of students and nearby residents [27]. According to the law of the Republic of Korea, when a chemical accident occurs, it is required to immediately report the accident and take emergency measures.…”

Section: E P U B a H E A D O F P R I N Tmentioning

confidence: 99%

An outbreak of neurologic symptoms among patients exposed to an unknown stench in a high school near an industrial complex: an epidemiological investigation

Baek¹,

Jo²,

Park³

et al. 2022

Epidemiol Health

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In a high school in Korea, seven students visited the emergency room with non-specific neurological symptoms after a stench occurred during the entrance ceremony. A total of 105 patients visited the medical center over five days. A team of environmental and epidemiologic experts was assembled to investigate the incident. MethodsOur team, consist of experts of epidemiology, participated in the investigation one month after the incident. Until then, only air samples were analyzed. We received results on air samples analyzed by other investigators, medical records of some students and police's patient interview data. Additional investigation and interview were performed. The events were reconstructed in spatial and temporal order. ResultsA cluster of patients were observed in the south and some parts of north sides of the upper floor. A stench similar to that at the time of the incident has been sensed about two years in school area. Students consistently stated that similar stench occurred frequently in the vicinity of the school. According to students' statements, odor pattern was mainly that of something burning. Some students' CO-Hb was observed to be >1.5%. ConclusionsIn the investigation process, two suspected sources were identified; a science room storing chemicals downstairs of the auditorium, and various industrial facilities located near the school. Combining the scattered evidence, our team considered toxic puff gas, maybe from incineration or leak in a specific area for a short time, was the cause of the incident. We describe our approaching process and the limitations encountered during investigation.

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Toluene concentrations in the blood and risk of thyroid cancer among residents living near national industrial complexes in South Korea: A population-based cohort study

Cited by 21 publications

References 29 publications

Profiling volatile organic compounds from human plasma using GC × GC-ToFMS

Profiling volatile organic compounds from human plasma using GC × GC-ToFMS

Blood Concentrations of Volatile Organic Compounds Among US Workers From Various Trades

An outbreak of neurologic symptoms among patients exposed to an unknown stench in a high school near an industrial complex: an epidemiological investigation

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