Toll-like receptors TLR1, TLR2 and TLR4 gene mutations and natural resistance to Mycobacterium avium subsp. paratuberculosis infection in cattle

Mucha, Rastislav; Bhide, Mangesh; Chakurkar, E.B.; Novák, Michal; Mikula, I.

doi:10.1016/j.vetimm.2008.12.007

Cited by 107 publications

(91 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Kb = kilobase. k Bovine health-related QTL overlapping or proximal to investigated gene (Q), or intragenic variation associated (A) with disease susceptibility in case-control studies (25)(26)(27)(28)(29)(30)(31). l Average across all investigated genes.…”

Section: Resultsmentioning

confidence: 99%

“…Validated polymorphisms, haplotype distributions, and tagSNPs/Indels elucidated in this study will directly facilitate fine mapping of existing bovine healthrelated QTL while also enabling independent evaluation of SNPs tentatively associated with susceptibility to Johne disease (25)(26)(27)(28)(29)(30)(31). Because of limitations related to our genotyping assays, we were able to technically ascertain all previously described coding polymorphisms (27)(28)(29)33) only for bovine TLR10, and TLR1 variants posed the greatest technical challenge because of sequence similarity with TLR6.…”

Section: Discussionmentioning

confidence: 99%

“…To date, several studies have demonstrated that some naturally occurring TLR variants enhance the risk of severe infections in humans, mice, and most recently, domestic cattle (23)(24)(25)(26). In addition to the emerging molecular and population-based casecontrol data, bovine health-related quantitative trait loci (QTL) have been localized to genomic regions either proximal to or directly overlapping one or more TLR loci, and at least two healthrelated QTL are proximal to PGLYRP1 (25)(26)(27)(28)(29)(30)(31).…”

mentioning

confidence: 99%

“…In addition to the emerging molecular and population-based casecontrol data, bovine health-related quantitative trait loci (QTL) have been localized to genomic regions either proximal to or directly overlapping one or more TLR loci, and at least two healthrelated QTL are proximal to PGLYRP1 (25)(26)(27)(28)(29)(30)(31). Unfortunately, the resolution of the highest density SNP assay available for cattle, the Illumina BovineSNP50 (32), is inadequate to resolve the identity of any of the TLRs as underlying these QTL.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Diversity and evolution of 11 innate immune genes in Bos taurus taurus and Bos taurus indicus cattle

Seabury

Seabury²,

Decker³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

100

View full text Add to dashboard Cite

The Toll-like receptor (TLR) and peptidoglycan recognition protein 1 (PGLYRP1) genes play key roles in the innate immune systems of mammals. While the TLRs recognize a variety of invading pathogens and induce innate immune responses, PGLYRP1 is directly microbicidal. We used custom allele-specific assays to genotype and validate 220 diallelic variants, including 54 nonsynonymous SNPs in 11 bovine innate immune genes (TLR1-TLR10, PGLYRP1) for 37 cattle breeds. Bayesian haplotype reconstructions and median joining networks revealed haplotype sharing between Bos taurus taurus and Bos taurus indicus breeds at every locus, and we were unable to differentiate between the specialized B. t. taurus beef and dairy breeds, despite an average polymorphism density of one locus per 219 bp. Ninety-nine tagSNPs and one tag insertion-deletion polymorphism were sufficient to predict 100% of the variation at all 11 innate immune loci in both subspecies and their hybrids, whereas 58 tagSNPs captured 100% of the variation at 172 loci in B. t. taurus. PolyPhen and SIFT analyses of nonsynonymous SNPs encoding amino acid replacements indicated that the majority of these substitutions were benign, but up to 31% were expected to potentially impact protein function. Several diversitybased tests provided support for strong purifying selection acting on TLR10 in B. t. taurus cattle. These results will broadly impact efforts related to bovine translational genomics.peptidoglycan recognition protein | bovine translational genomics | bovine Toll-like receptors | single nucleotide polymorphism

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Diversity and evolution of 11 innate immune genes in Bos taurus taurus and Bos taurus indicus cattle

Seabury

Seabury²,

Decker³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

100

View full text Add to dashboard Cite

show abstract

“…Firstly, interferon regulates HBV DNA replication by both immunomodulatory [4] and directly antiviral mechamism. Furthermore, as far as direct antiviral mechamism is concerned, except for HBV IRE-dependant pathway, interferon has the potential to trigger the activation of other multiple noncytolytic intracellur antiviral pathways that can target many steps in the viral life [2,11,12,23]. In a word, multiple mechanisms might be involved in antiviral effect by interferon on HBV, and IRE-dependant mechanism investigated in our present study was one of them.…”

Section: Discussionmentioning

confidence: 74%

Functional Characterization of Interferon Regulation Element of Hepatitis B virus Genome In Vivo

et al. 2012

View full text Add to dashboard Cite

The roles of interferon regulatory element (IRE) in Hepatitis B virus (HBV) genome on inhibitory effect of interferon against HBV are controversial in vitro. This study aimed to determine the functional characterization of HBV-IRE sequence in vivo. Wild-type or IRE-mutant HBV replication-competent mice were firstly established, and mice were subquently treated with polyinosinic-polytidylin acid (polyI.C) or phosphate-buffered saline via intraperitoneal. Results showed that PolyI.C inhibited viral replication, and increased the level of 2 0 ,5 0 -oligoadenylate synthase mRNA transcripts, a marker of INF-a/b induction. Between wildtype and IRE-mutant HBV replication-competent mice, the levels of HBV-RNA and HBV-DNA replication intermediates were similar. After PolyI.C treatment, the decreasing of HBV-RNA was similar between two groups, but HBV-DNA replication intermediates decreased significantly less in IREmutant than wild-type HBV replication-competent mice. These findings suggested that IRE mutant reduced the inhibitory effect of interferon on HBV replication, which played a role in antiviral effect of interferon against HBV.

show abstract

Response of the respiratory mucosal cells to mycobacterium avium subsp. Hominissuis microaggregate

Babrak

Bermudez

2018

Arch Microbiol

View full text Add to dashboard Cite

Toll-like receptors TLR1, TLR2 and TLR4 gene mutations and natural resistance to Mycobacterium avium subsp. paratuberculosis infection in cattle

Cited by 107 publications

References 60 publications

Diversity and evolution of 11 innate immune genes in Bos taurus taurus and Bos taurus indicus cattle

Diversity and evolution of 11 innate immune genes in Bos taurus taurus and Bos taurus indicus cattle

Functional Characterization of Interferon Regulation Element of Hepatitis B virus Genome In Vivo

Response of the respiratory mucosal cells to mycobacterium avium subsp. Hominissuis microaggregate

Contact Info

Product

Resources

About