Toll-like Receptors Signaling Pathways as a Potential Therapeutic Target in Cardiovascular Disease

Parizadeh, Seyed Mostafa; Ghandehari, Maryam; Heydari-majd, Motahareh; Seifi, Sima; Mardani, Ramin; Ghayour‐Mobarhan, Majid; Hassanian, Seyed Mahdi

doi:10.2174/1381612824666180614090224

Cited by 24 publications

(14 citation statements)

References 86 publications

(124 reference statements)

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“…microRNAs (miRNAs or miRs) are small, single‐stranded, nonprotein‐coding ribonucleic acids (RNAs) composed of approximately 19–22 nucleotides long . miRNAs can be found in different body fluids .…”

Section: Role Of Micrornas In Targeting C‐met/hgf Signaling Pathwaymentioning

confidence: 98%

The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer

et al. 2019

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Colorectal cancer (CRC) is the third most common cancer and a common cause of cancer‐related mortality globally. In spite of the improvements in the early diagnosis of CRC, approximately one‐third of patients develop metastasis and then have a very poor survival rate. The mesenchymal–epithelial transition factor (c‐MET) is a tyrosine kinase cell surface receptor activated by hepatocyte growth factor (HGF). Activation of c‐MET/HGF signaling pathway regulates a variety of biological processes including cell motility, cell proliferation, angiogenesis, the epithelial‐to‐mesenchymal transition, and the development and progression of cancer cells. Recent studies have suggested that the c‐MET/HGF signaling pathway is involved in the carcinogenesis of CRC. In this review, we summarize the main findings of recent studies investigating the role of c‐MET/HGF signaling pathway in CRC and the potential of the c‐MET/HGF signaling pathways in the diagnosis and treatment of CRC. © 2019 IUBMB Life, 2019

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Section: Role Of Micrornas In Targeting C‐met/hgf Signaling Pathwaymentioning

confidence: 98%

The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer

et al. 2019

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“…Taken together, reduction of TLR-induced inflammation may prevent CVD initiation or progression. [41][42][43]…”

Section: Tlr Pathwaymentioning

confidence: 99%

Ginger: A complementary approach for management of cardiovascular diseases

et al. 2021

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Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Inflammation and oxidative stress play critical roles in progression of various types of CVD. Broad pharmacological properties of ginger (the rhizome of Zingiber officinale) and its bioactive components have been reported, suggesting that they can be a therapeutic choice for clinical use. Consistent with its rich phenolic content, the anti-inflammatory and antioxidant properties of ginger have been confirmed in many studies. Ginger modifies many cellular processes and in particular was shown to have potent inhibitory effects against nuclear factor kappa B (NF-κB); signal transducer and activator of transcription; NOD-, LRR-, and pyrin domain-containing proteins; toll-like receptors; mitogenactivated protein kinase; and mammalian target of rapamycin signaling pathways. Ginger also blocks pro-inflammatory cytokines and the activation of the immune system. Ginger suppresses the activity of oxidative molecules such as

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“…Further, it was identi ed that downregulating IL-17 expression could suppress in ammation and improve heart function [64]. TNF signaling also induces in ammatory response by activating the expression of proin ammatory cytokines and transcription factors [65]. For example, TNF combined with TNF receptor 1 (TNFR1) mediated the activation of NF-kB, which was involved in the pathological process of cardiovascular disease such as ischemia-reperfusion, heart failure, and ventricular remodeling [66].…”

Section: Discussionmentioning

confidence: 99%

A Network Pharmacology Analysis to Reveal the Molecular Mechanism of Zhizi-Danshen on Coronary Heart Disease

Shen¹,

Wang²,

Wu³

et al. 2020

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ObjectiveOur study aimed to investigate the potential mechanisms of the herb pair Zhizi-Danshen (ZD) for coronary heart disease (CHD) using network pharmacological data mining technology.MethodsThe Traditional Chinese Medicine System Pharmacology (TCMSP) database was used to collect the active ingredients of ZD and predict ZD-related target proteins. Afterwards, we identified CHD-related targets from DisGeNET database, NCBI gene database, and TTD database. The common targets both from ZD and CHD were screened by Venny2.1, which were then imported into the String database for protein-protein interaction (PPI) analysis. Finally, the GO and KEGG enrichment analysis were performed by R software, and the network construction was established using Cytoscape3.7.2.ResultsWe obtained 199 possible targets from 62 candidate ingredients of ZD and 1033 CHD-ralated targets, with 83 overlapping common target genes. Then, 11 core targets were acquired from PPI network analysis. Further, GO analysis showed that these common targets mainly influenced receptor ligand activity，cytokine activity，cytokine receptor binding，steroid hormone receptor activity, and peptide binding. KEGG pathway analysis indicated that ZD affected CHD through seven important pathways linked to vascular endothelial function regulation (fluid shear stress and atherosclerosis，AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway), imflammatory effects (IL-17 signaling pathway, TNF signaling pathway，Toll-like receptor signaling pathway)，and hormone regulation (relaxin signaling pathway). ConclusionsThis study revealed the potential pharmacological mechanisms of ZD against CHD, which were mainly associated with regulation of vascular endothelial function and inflammatory effects, promotion of vasodilatation, and prevention of cardiac fibrosis. Moreover, it provided a novel conception for the development of alternative therapies on CHD.

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Toll-like Receptors Signaling Pathways as a Potential Therapeutic Target in Cardiovascular Disease

Cited by 24 publications

References 86 publications

The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer

The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer

Ginger: A complementary approach for management of cardiovascular diseases

A Network Pharmacology Analysis to Reveal the Molecular Mechanism of Zhizi-Danshen on Coronary Heart Disease

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