Toll-like receptors gene polymorphisms may confer increased susceptibility to breast cancer development

Theodoropoulos, George; Saridakis, Vasilios; Karantanos, Theodoros; Michalopoulos, Nikolaos V.; Zagouri, Flora; Kontogianni, Panagiota; Lymperi, Maria; Gazouli, Maria; Zografos, George

doi:10.1016/j.breast.2012.04.001

Cited by 70 publications

(36 citation statements)

References 29 publications

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“…Moreover, recent epidemiological studies on different ethnic groups have indicated that TLR2Δ22 (-196-174 del) polymorphisms in toll-like receptor (TLR) family, significantly increases the risk of cervical, gastric, breast and hepatocellular cancers [15,24,25] but not in case of bladder, prostate and gallbladder cancers [16,26,27]. One recent study conducted on 261 BC patients and 480 healthy individuals has shown that genotype and allelic frequencies of a 22-bp nucleotide deletion (-196-174 del) in the promoter of TLR2 gene is significantly associated with increased risk of BC [24].…”

Section: Introductionmentioning

confidence: 99%

TLR2∆22 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene: a case–control study from four ethnic groups of North Eastern region of India

et al. 2015

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Breast cancer (BC) is the second most common cancer in women. In the North Eastern Region (NER) of India, BC is emerging as an important concern as evidenced by the data available from population and hospital-based cancer registries. Studies on genetic susceptibility to BC are important to understand the increase in the incidence of BC in NER. The present case control study was conducted to investigate the association between tumour suppressor gene TP53 codon 72 polymorphism and innate immune pathway gene TLR2∆22 (-196-174) polymorphism with BC in females of NER of India for the identification of novel biomarker of BC. Four hundred sixty-two histopathologically confirmed BC cases from four states of NER of India, and 770 healthy controls were included by organizing community surveys from the neighbourhood of cases. In our study, no significant association between TP53 codon 72 polymorphisms and the risk of BC was found. However, our study has shown that TP53 codon 72 polymorphism is an important effect modifier. In the present study it was found that females carrying 22 base-pair deletion in the promoter region of their TLR2 gene had two times (AOR= 2.18, 95 % CI 1.13-4.21, p=0.019 in dominant model; AOR= 2.17, 95 % CI 1.09-4.34, p=0.027 in co-dominant model) increased risk of BC whwn they also carry proline allele at codon 72 of their TP53 gene.

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Section: Introductionmentioning

confidence: 99%

TLR2∆22 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene: a case–control study from four ethnic groups of North Eastern region of India

et al. 2015

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“…There were many studies reported the association between Delta22 polymorphism and cancer risk and we also performed a meta-analysis on Delta22 inspired by the meta-analysis in Neoplasma. However, we found a significant publication bias by Begg's funnel plots and sensitivity analysis suggested that the study by Theodoropoulos et al (2012) significantly affect the pooled results (data not shown). In addition, for the +1350C>T polymorphism (rs3804100), we excluded a study of acute lymphoblastic leukemia (ALL), and added another one of thyroid cancer (Kim et DOI:http://dx.doi.org/10.7314/APJCP.2013.14.10.5871 Lack of Association of TLR2+597T>C, +1350C>T and Arg753Gln with Cancer Risk: A Meta-analysis al., 2012.…”

Section: Discussionmentioning

confidence: 76%

Lack of Association of Three Common Polymorphisms in Toll-like receptors (TLRs), TLR2+597T>C, +1350C>T and Arg753Gln with Cancer Risk: a Meta-analysis

Yang

Wang²,

Qiu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…In agreement with these findings, Etokebe et al (34) failed to demonstrate any correlation between the TLR2 d allele and breast cancer development. However, a study by Theodoropoulos et al (35) reported a positive association between this polymorphism and an increased risk of breast cancer in the Greek population. The reason for this discordance may be attributed to different genetic backgrounds between the studied populations, varying sample sizes and heterogeneity of the tumors examined (36).…”

Section: Discussionmentioning

confidence: 95%

Polymorphisms of glutathione S-transferase π 1 and toll-like receptors 2 and 9: Association with breast cancer susceptibility

et al. 2016

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Abstract. Polymorphisms in antioxidant enzymes and innate immune receptors have been implicated in the development of various types of cancer. The present study aimed to investigate whether polymorphisms of glutathione S-transferase π 1 (GSTP1) and toll-like receptors (TLRs) 2 and 9 are associated with susceptibility to breast cancer among females. The study was conducted on 72 Egyptian female patients with breast cancer, along with 100 healthy volunteers. Polymorphisms of GSTP1 (codon 105 Ile/Val) and TLR9 rs187084 (1237T/C) genes were assessed by polymerase chain reaction (PCR)-restriction fragment length polymorphism, while the -196 to -174 deletion/insertion (del/ins) polymorphism of TLR2 was detected by PCR. The results indicated a decrease in GSTP1 Val allele frequency in breast cancer patients compared with healthy controls, at rates of 22.9 vs. 32.5%, respectively. In addition, the breast cancer group demonstrated a decreased TLR9 C allele frequency compared with the control group, at rates of 36.1 vs. 51.5%, respectively (P=0.0047). A non-significant difference was detected in the frequency of the TLR2 -196 to -174 del allele in breast cancer patients when compared to normal controls. In conclusion, these results suggested that the GSTP1 Val and TLR9 1237C alleles, but not TLR2 -196 to -174 del, are likely to be associated with breast cancer development among females.

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Toll-like receptors gene polymorphisms may confer increased susceptibility to breast cancer development

Cited by 70 publications

References 29 publications

TLR2∆22 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene: a case–control study from four ethnic groups of North Eastern region of India

TLR2∆22 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene: a case–control study from four ethnic groups of North Eastern region of India

Lack of Association of Three Common Polymorphisms in Toll-like receptors (TLRs), TLR2+597T>C, +1350C>T and Arg753Gln with Cancer Risk: a Meta-analysis

Polymorphisms of glutathione S-transferase π 1 and toll-like receptors 2 and 9: Association with breast cancer susceptibility

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