Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells

Law, Helen K. W.; Cheung, Chung Yan; Sia, Sin Fun; Chan, Yuen-Yan; Peiris, J. S. Malik; Lau, Yu Lung

doi:10.1186/1471-2172-10-35

Cited by 47 publications

(49 citation statements)

References 46 publications

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“…The inverse correlation among the levels of the proapoptotic TRAIL and the counts of CD4+ and CD8+ T lymphocyte subpopulations supports the hypothesis that TRAIL is related to lymphocytic cell death. A similar phenomenon has been reported in patients infected with HIV [Cummins and Badley, ], respiratory syncytial virus [Roe et al, ], SARS coronavirus [Law et al, ], measles virus [Okada et al, ], and in primate models of Ebola virus disease [Hensley et al, ]. Therefore, apoptosis might be a contributing factor that modulates the number of lymphocytes in dengue infection, as documented previously [Myint et al, ].…”

Section: Discussionsupporting

confidence: 80%

Apoptotic mediators in patients with severe and non‐severe dengue from Brazil

Limonta

Torrentes-Carvalho

Marinho

et al. 2013

Journal of Medical Virology

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Despite being the most significant arboviral disease worldwide, dengue has no antiviral treatment or reliable severity predictors. It has been shown that apoptotic cells from blood and tissues may be involved in the complex pathogenesis of dengue. However, very little is known about the interplay between proapoptotic and antiapoptotic mediators in this disease. Therefore, plasma levels of the three proapoptotic mediators Fas ligand (FasL), tumor necrosis factor-α (TNF-α), and TNF-related apoptosis-inducing ligand (TRAIL) were measured in dengue patients. Patients were classified according to the World Health Organization classification of dengue revised in 2009. Additionally, inhibitors of apoptosis protein (IAPs) were determined in plasma (Survivin) and peripheral blood mononuclear cells (PBMCs) lysates (cIAP-1, cIAP-2, XIAP). Levels of apoptotic proteins in plasma were correlated with counts of blood cells. FasL and TRAIL levels were elevated in dengue patients without warning signs when compared to patients with severe dengue and controls. Dengue patients with warning signs showed decreased levels of Survivin compared to patients with severe dengue and controls. TRAIL was inversely correlated with counts of lymphocyte subsets. In contrast, Survivin was positively correlated with leukocyte counts. There was a trend of elevated IAPs levels in PBMCs of patients with severe dengue. The results suggest a likely antiviral effect of TRAIL in dengue. It appears that TRAIL might be involved with apoptosis induction of lymphocytes, whereas IAPs might participate in protecting leukocytes from apoptosis. Further research is needed to explore the interactions between pro and antiapoptotic molecules and their implications in dengue pathogenesis.

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Section: Discussionsupporting

confidence: 80%

Apoptotic mediators in patients with severe and non‐severe dengue from Brazil

Limonta

Torrentes-Carvalho

Marinho

et al. 2013

Journal of Medical Virology

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“…Although the consequences of the timing of these signals are not yet understood, SARS-CoV infection of susceptible aged mice leads to elevated levels of proinflammatory cytokines with ARDS association, including TNFa, IL-6, and IL-1b [30,31]. Chemokine receptors CCR1, CCR2, and CCR5 have protective roles during MA15-SARS-CoV infection in the mouse model as well as SARS-CoV infection of human DCs, indicating the importance of cell recruitment in controlling SARS-CoV infections [51,53]. Transcriptional profiles of ISGs associated with increased SARS-CoV disease have been described in several model systems, but the consequences of ISG signaling responses to SARS-CoV infection has not been characterized [23 ,31,40 ,41 ,50 ].…”

Section: Cytokines Chemokines and Isgsmentioning

confidence: 99%

SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon

Totura

Baric

2012

Current Opinion in Virology

384

437

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SARS-CoV is a pathogenic coronavirus that emerged from a zoonotic reservoir, leading to global dissemination of the virus. The association SARS-CoV with aberrant cytokine, chemokine, and Interferon Stimulated Gene (ISG) responses in patients provided evidence that SARS-CoV pathogenesis is at least partially controlled by innate immune signaling. Utilizing models for SARS-CoV infection, key components of innate immune signaling pathways have been identified as protective factors against SARS-CoV disease, including STAT1 and MyD88. Gene transcription signatures unique to SARS-CoV disease states have been identified, but host factors that regulate exacerbated disease phenotypes still remain largely undetermined. SARS-CoV encodes several proteins that modulate innate immune signaling through the antagonism of the induction of Interferon and by avoidance of ISG effector functions.

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“…SARS-CoV also infects human MØs and DCs, but viral replication is abortive and no infectious virus particles are produced Law et al, 2005;Tseng et al, 2005;Yilla et al, 2005;Ziegler et al, 2005). Despite the lack of productive infection in human MØs, SARS-CoV induced the expression of proinflammatory chemokines, including CXCL-10 and CCL-2 but, in contrast, antiviral cytokines such as IFN-α and INF-β were basically absent Law et al, 2005Law et al, , 2009Tseng et al, 2005). In unproductive infections of DCs, SARS-CoV induced CXCL-10, CCL-2, CCL-3, CCL-5, and CXCL-10 " CXCL-10 " CXCL-10 # Apoptosis CCL-2, -36, -5 " CCL-5…”

Section: Interaction Of Cov Vaccine Candidates With Cells Of the Immumentioning

confidence: 99%

Molecular Basis of Coronavirus Virulence and Vaccine Development

Enjuanes

Zúñiga

Castaño-Rodríguez

et al. 2016

Advances in Virus Research

147

141

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Virus vaccines have to be immunogenic, sufficiently stable, safe, and suitable to induce long-lasting immunity. To meet these requirements, vaccine studies need to provide a comprehensive understanding of (i) the protective roles of antiviral B and T-cell-mediated immune responses, (ii) the complexity and plasticity of major viral antigens, and (iii) virus molecular biology and pathogenesis. There are many types of vaccines including subunit vaccines, whole-inactivated virus, vectored, and live-attenuated virus vaccines, each of which featuring specific advantages and limitations. While nonliving virus vaccines have clear advantages in being safe and stable, they may cause side effects and be less efficacious compared to live-attenuated virus vaccines. In most cases, the latter induce long-lasting immunity but they may require special safety measures to prevent reversion to highly virulent viruses following vaccination. The chapter summarizes the recent progress in the development of coronavirus (CoV) vaccines, focusing on two zoonotic CoVs, the severe acute respiratory syndrome CoV (SARS-CoV), and the Middle East respiratory syndrome CoV, both of which cause deadly disease and epidemics in humans. The development of attenuated virus vaccines to combat infections caused by highly pathogenic CoVs was largely based on the identification and characterization of viral virulence proteins that, for example, interfere with the innate and adaptive immune response or are involved in interactions with specific cell types, such as macrophages, dendritic and epithelial cells, and T lymphocytes, thereby modulating antiviral host responses and viral pathogenesis and potentially resulting in deleterious side effects following vaccination.

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Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells

Cited by 47 publications

References 46 publications

Apoptotic mediators in patients with severe and non‐severe dengue from Brazil

Apoptotic mediators in patients with severe and non‐severe dengue from Brazil

SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon

Molecular Basis of Coronavirus Virulence and Vaccine Development

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