Toll-like receptors and the tendency of normal mucous membrane to transform to polyp or colorectal cancer

Niedzielska, Iwona; Orawczyk, Tomasz; Ziaja, Krzysztof; Tkacz, Magdalena; Starzewski, J; M, Ciopała; Kalaciński, J; Niedzielski, Zbigniew; Mazurek, Urszula; Ziaja, Damian; Zalinski, G.

doi:10.1016/j.ijom.2009.03.619

Cited by 25 publications

(35 citation statements)

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“…Recently, several studies have demonstrated that the presence of the TLR-4 Asp299Gly polymorphism is associated with a higher frequency of prostate cancer in the North Indian population 31. It has also been shown that TLRs are implicated in the progression of polyps to tumors and that increased metastatic potential of colorectal cancers was correlated with reduced TLR expression 31,32. TLR-4 polymorphism rs11536898 has also been shown to be connected with colon cancer 26.…”

Section: Introductionmentioning

confidence: 99%

Toll-like receptor-4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women

Semlali¹,

Jalouli²,

Parine³

et al. 2017

OTT

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The aim of this study was to investigate the association of the common polymorphisms of Toll-like receptor 4 (TLR-4) with breast cancer development in the Saudi Arabian population. Four TLR-4 polymorphisms (rs2770150, rs10759931, rs10759932, and rs4986790) were studied using 127 breast cancer patients and 117 controls. Relative expression of TLR-4 protein in the breast tumor and the matched normal breast tissues was determined in a large cohort of 70 clinical breast samples in a tissue micro-array format by immunohistochemistry using a specific anti-TLR-4 antibody. Our results demonstrated an increase in TLR-4 expression in estrogen receptor (ER)−, postmenopausal breast cancer patients compared to normal. We also demonstrated that the G allele of single-nucleotide polymorphism rs10759931 was found to be significantly higher in frequency among patients (36.3%) compared to the control group (26.7%), suggesting that this polymorphism is strongly associated with the development of breast cancer in this ethnic population. In addition, the TLR-4 polymorphism rs2770150 was shown to be highly correlated with breast cancer in patients over 48 years of age. The TLR-4 polymorphism rs4986790 was also found to be associated with this malignancy in the ER− patient groups. Our results suggested firstly that the variation in TLR-4 gene expression may influence breast cancer development and secondly a closely linked association between TLR-4 gene polymorphism and ER status. Our study provides support for a better understanding of the implication of TLR-4 polymorphism in breast tumorigenesis and for its eventual use as a cancer biomarker.

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Section: Introductionmentioning

confidence: 99%

Toll-like receptor-4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women

Semlali¹,

Jalouli²,

Parine³

et al. 2017

OTT

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“…A study by Xiao and colleagues [6] showed that decreased TLR signaling resulted in increased intestinal inflammation further suggesting the importance of TLR signaling in colon carcinogenesis [2]. Studies also have demonstrated that TLRs play a role in progression of polyps to tumors and that reduced TLR4 expression is associated with increased metastatic potential of colorectal cancers [7, 8]. TLR5 has been shown to protect the gut from enteric microbes [9].…”

Section: Introductionmentioning

confidence: 99%

Toll‐like receptor genes and their association with colon and rectal cancer development and prognosis

Slattery

Herrick

Bondurant

et al. 2011

Intl Journal of Cancer

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Toll-like receptors (TLR) are mediators of inflammation in the gut and potentially important modulators of colon and rectal cancer risk. We use data from a population-based study of incident colon cancer cases (n=1,555) and controls (n=1,956) and rectal cancer cases (n=754) and controls (n=959). We evaluate genetic variation in TLR2 (6 SNPs), TLR3 (4 SNPs), and TLR4 (8 SNPs) with risk of developing colon or rectal cancer and survival after diagnosis. TLR3 rs11721827 was associated with rectal cancer (OR 1.27 95% CI 1.02,1.58 for AC/CC vs AA genotype Wald p 0.035; adjusted p 0.126); TLR3 rs3775292 and TLR4 rs11536898 were associated with colon cancer (OR 0.68 95% CI 0.49,0.95 for GG vs CC/CG and OR 0.50 95% CI 0.29,0.87 for AA vs. CA/CC respectively; Wald p=0.023 and 0.015; adjusted p=0.085 and 0.101 respectively). TLR2 rs7656411 and rs3804099 respectively interacted with NSAID use and cigarette smoking to alter risk of colon cancer (adjusted p=0.034 and 0.077); TLR3 rs11721827 interacted with NSAID use to alter risk of colon cancer (adjusted p=0.071). TLR3 rs3775292 interacted with dietary carbohydrates to alter colon cancer risk and with dietary carbohydrates and saturated fat to alter rectal cancer risk (adjusted p=0.064, 0.0035, and 0.025 respectively). Multiple SNPs in TLR2 and TLR4 were associated with colon cancer survival. Although few independent associations with TLR genes were observed, we observed significant interaction with TLR2 and TLR3 with hypothesized lifestyle factors. Interaction with dietary factors remained significant for rectal cancer after adjustment for multiple comparisons.

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“…Very recent experimental data indicate that TLR protects the intestine from inflammation-induced carcinogenesis [8, 9, ]. In addition, it is of note that low TLR7 mRNA may indicate the tendency of normal tissue to form polyps transforming to CC [17]. Likewise, it has been reported that TLR agonists induce antitumor activity [16,18].…”

Section: Discussionmentioning

confidence: 96%

Study of the Expression of Toll-Like Receptors in Different Histological Types of Colorectal Polyps and Their Relationship with Colorectal Cancer

Eiró

González

et al. 2012

J Clin Immunol

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Toll-like receptors and the tendency of normal mucous membrane to transform to polyp or colorectal cancer

Cited by 25 publications

References 0 publications

Toll-like receptor-4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women

Toll-like receptor-4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women

Toll‐like receptor genes and their association with colon and rectal cancer development and prognosis

Study of the Expression of Toll-Like Receptors in Different Histological Types of Colorectal Polyps and Their Relationship with Colorectal Cancer

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