Toll-like receptor signalling as a cannabinoid target

Cui Sun, Melody; Otálora-Alcaraz, Almudena; Prenderville, Jack A.; Downer, Eric J.

doi:10.1016/j.bcp.2024.116082

Cited by 6 publications

(2 citation statements)

References 205 publications

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“…Cannabinoids may exert these anti‐inflammatory properties by modulating TLR signalling, including TLR4. 7 It is thought that cannabinoids attenuate the myeloid differentiation primary response 88 (MyD88)‐dependent pathway to decrease nuclear factor‐κB (NF‐κB) activity, resulting in a decrease in cytokine production and cell growth through TLR2 and TLR4. 38 TLR4 is the primary TLR associated with alcohol use, its downstream increases in production of proinflammatory cytokines 2 , 3 and the subsequent increase in severity of alcohol problems, 4 , 6 alcohol craving and alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

“…There is substantial evidence that TLR4 signalling is also impacted by phytocannabinoids, such as cannabidiol (CBD) and cannabigerol (CBG), which are neuroprotective and reduce proinflammatory cytokine release. 7 Delta‐9‐tetrahydrocannabinol (THC), the main psychoactive phytocannabinoid, may not share these anti‐inflammatory properties, as some evidence suggests that THC alone may not decrease proinflammatory cytokines. 8 Findings have been mixed regarding cannabis use and IL‐6.…”

Section: Introductionmentioning

confidence: 99%

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Examining the moderating role of cannabis use on the relationship between alcohol consumption and inflammation in individuals with alcohol use disorder

Grodin,

McManus,

Ray

2024

Addiction Biology

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Inflammation appears to be a critical mechanism in the development of alcohol use disorder (AUD) and a consequence of chronic alcohol use. The potential anti‐inflammatory properties of cannabis may modulate the proinflammatory effects of alcohol. This study sought to extend previous work investigating the relationship between alcohol consumption, cannabis use and circulating interleukin (IL)‐6 levels in a sample with AUD. One hundred and thirty‐three individuals with an AUD provided blood samples to assess IL‐6 and answered questions regarding alcohol and cannabis use. An ordinary least squares multiple regression analysis was conducted to assess the effect of alcohol and cannabis use on IL‐6. A moderation analysis examined cannabis use as a potential moderator of the relationship between alcohol use and circulating IL‐6 levels. Alcohol use was predictive of higher log IL‐6 levels (standardized β = 0.16, p = 0.03), while cannabis use was not predictive of log IL‐6 levels (p = 0.36). Days of cannabis use moderated the relationship between alcohol use and IL‐6 levels, such that the relationship between alcohol use and IL‐6 levels was only significant in individuals with AUD without recent cannabis use. This study extends previous work to a clinical sample with an AUD and underscores the importance of considering cannabis use in studies on alcohol use and inflammation. This study also indicates the need for in‐depth analyses on cannabinoids and inflammation and the interaction between cannabinoids and alcohol use on inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Examining the moderating role of cannabis use on the relationship between alcohol consumption and inflammation in individuals with alcohol use disorder

Grodin,

McManus,

Ray

2024

Addiction Biology

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Endocannabinoid system and phytocannabinoids in the main species of veterinary interest: a comparative review

Di Salvo,

Chiaradia,

Sforna

et al. 2024

Vet Res Commun

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Since the discovery of the endocannabinoid system and due to the empirical evidence of the therapeutic effects on several illnesses both in humans and animals that follow the administration of exogenous cannabinoids (i.e., phytocannabinoids), numerous studies have been conducted. These investigations aimed to identify the expression and distribution of cannabinoid receptors in healthy and pathologic organs and tissues of different animal species and to define the interactions of phytocannabinoids with these receptors. In the last decade, pharmacokinetics, efficacy and tolerability of many Cannabis derivatives formulations, mainly containing cannabidiol, in the main species of veterinary interest, have been also investigated. This manuscript summarizes the findings reported by the scientific studies published so far on the molecular mode of action of the main phytocannabinoids, the localization of cannabinoid receptors in organs and tissues, as well as the pharmacokinetics, efficacy and tolerability of Cannabis derivatives in dogs, cats, horses and other species of veterinary interest. A deep knowledge of these issues is crucial for the use of phytocannabinoids for therapeutic purposes in animal species.

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Novel Heterocyclic Compounds as Monoacylglycerol Lipase Inhibitors for Treating Multiple Diseases

Sabnis

2024

ACS Med. Chem. Lett.

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Toll-like receptor signalling as a cannabinoid target

Cited by 6 publications

References 205 publications

Examining the moderating role of cannabis use on the relationship between alcohol consumption and inflammation in individuals with alcohol use disorder

Examining the moderating role of cannabis use on the relationship between alcohol consumption and inflammation in individuals with alcohol use disorder

Endocannabinoid system and phytocannabinoids in the main species of veterinary interest: a comparative review

Novel Heterocyclic Compounds as Monoacylglycerol Lipase Inhibitors for Treating Multiple Diseases

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