Toll-like receptor signaling and serum levels of interferon β and lipopolysaccharide binding protein are related to abdominal obesity: a case-control study between metabolically healthy and metabolically unhealthy obese individuals

Naghizadeh, Mahsa; Baradaran, Behzad; Saghafi-Asl, Maryam; Amiri, Parichehr; Shanehbandi, Dariush; Karamzad, Nahid; Mohamed-Khosroshahi, Leila

doi:10.1016/j.nutres.2018.03.014

Cited by 10 publications

(9 citation statements)

References 42 publications

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“…The relative variations of LBP/sCD14 ratio are also considered important in the inflammation set-up [ 14 ]. Furthermore, higher plasma LBP concentrations have been observed in obesity [ 7 , 13 , 15 ] and plasma LBP concentration is associated to abdominal obesity [ 16 ]. We have recently shown that increase of plasma IL-6 is linked to a rise of LBP/sCD14 ratio in both humans [ 14 ] and mice [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Postprandial Endotoxin Transporters LBP and sCD14 Differ in Obese vs. Overweight and Normal Weight Men during Fat-Rich Meal Digestion

et al. 2020

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Circulating levels of lipopolysaccharide-binding protein (LBP) and soluble cluster of differentiation 14 (sCD14) are recognized as clinical markers of endotoxemia. In obese men, postprandial endotoxemia is modulated by the amount of fat ingested, being higher compared to normal-weight (NW) subjects. Relative variations of LBP/sCD14 ratio in response to overfeeding are also considered important in the inflammation set-up, as measured through IL-6 concentration. We tested the hypothesis that postprandial LBP and sCD14 circulating concentrations differed in obese vs. overweight and NW men after a fat-rich meal. We thus analyzed the postprandial kinetics of LBP and sCD14 in the context of two clinical trials involving postprandial tests in normal-, over-weight and obese men. In the first clinical trial eight NW and 8 obese men ingested breakfasts containing 10 vs. 40 g of fat. In the second clinical trial, 18 healthy men were overfed during 8 weeks. sCD14, LBP and Il-6 were measured in all subjects during 5 h after test meal. Obese men presented a higher fasting and postprandial LBP concentration in plasma than NW men regardless of fat load, while postprandial sCD14 was similar in both groups. Irrespective of the overfeeding treatment, we observed postprandial increase of sCD14 and decrease of LBP before and after OF. In obese individuals receiving a 10 g fat load, whereas IL-6 increased 5h after meal, LBP and sCD14 did not increase. No direct association between the postprandial kinetics of endotoxemia markers sCD14 and LBP and of inflammation in obese men was observed in this study.

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Section: Introductionmentioning

confidence: 99%

Postprandial Endotoxin Transporters LBP and sCD14 Differ in Obese vs. Overweight and Normal Weight Men during Fat-Rich Meal Digestion

et al. 2020

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“…128 TLR4 and TRIF gene expression, however, have not been changed among obese individuals with or without MetS and abdominal obesity. 129 TLR4 endogenous ligands such as LPS, saturated fatty acid, and ox-LDL are abundantly produced during obesity. [130][131][132][133][134] HSPs are another TLR ligand which restores tissue homeostasis.…”

Section: Underlying Cellular Mechanisms Of Lgsi During Obesity Pattermentioning

confidence: 99%

“…147 Although LBP serum levels are not changed in OB individuals without MetS, TLR4, and TRIF mRNA expression levels have significantly correlated with LPB serum levels among them. 129 Importantly, some evidence has shown the roles of CD14 and sCD14 in obesity-related diseases such as IR, steatohepatitis, and MetS. [148][149][150] TLR4 signaling also depends on a co-receptor named myeloid differentiation factor-2 (MD2), so that MD2 deficiency leads to hepatocyte resistance in diet-induced steatohepatitis.…”

Section: Lbp/tlr4/cd14 Axismentioning

confidence: 99%

<p>The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions</p>

Soltani¹,

Marandi²,

Kazemi³

et al. 2020

DMSO

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Reduced physical activity rate in people's lifestyle is a global concern associated with the prevalence of health disorders such as obesity and metabolic disturbance. Ample evidence has indicated a critical role of the immune system in the aggravation of obesity. The type, duration, and production of adipose tissue-released mediators may change subsequent inactive lifestyle-induced obesity, leading to the chronic systematic inflammation and monocyte/macrophage (MON/MФ) phenotype polarization. Preliminary adipose tissue expansion can be inhibited by changing the lifestyle. In this context, exercise training is widely recommended due to a definite improvement of energy balance and the potential impacts on the inflammatory signaling cascades. How exercise training affects the immune system has not yet been fully elucidated, because its anti-inflammatory, pro-inflammatory, or even immunosuppressive impacts have been indicated in the literature. A thorough understanding of the mechanisms triggered by exercise can suggest a new approach to combat metainflammation-induced metabolic diseases. In this review, we summarized the obesityinduced inflammatory pathways, the roles of MON/MФ polarization in adipose tissue and systemic inflammation, and the underlying inflammatory mechanisms triggered by exercise during obesity.

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“…low-grade chronic inflammatory state, characterized by increased levels of inflammatory cytokines, such as C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNFα) [2,3]. However, the triggering factors of inflammation, obesity, and T2DM remain to be further clarified.…”

mentioning

confidence: 99%

“…Two LPS-pathway proteins, including cluster of differentiation 14 (CD14) and LPSbinding protein (LBP), are widely used as indirect measures of response to the LPS endotoxin in numerous experimental studies [7]. Increased circulating LPS and LBP concentrations have been found in patients with obesity [2,8].…”

mentioning

confidence: 99%

Lipopolysaccharide and inflammatory cytokines levels decreased after sleeve gastrectomy in Chinese adults with obesity

Guan

et al. 2019

Endocr J

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Obesity is linked to a low-grade systemic inflammation and lipopolysaccharide (LPS) is a key factor. Sleeve gastrectomy (SG) can significantly cause weight loss, but few reports have looked into the changes of LPS and inflammatory cytokines after surgery. To explore the potential short-term impact of SG on LPS and inflammatory cytokines and their relationship to early metabolic changes in obesity. 30 Chinese adults with obesity (BMI 39.37 ± 8.22 kg/m 2 , 25 female) receiving SG were included in this study. Fasting blood samples were collected at baseline and 30 days after SG. Serum LPS markedly reduced from 336.50 (73.54, 500) pg/mL to 5.00 (5.00, 5.24) pg/mL at 1 month after SG (p < 0.05). There was a significant decrease in plasma IL-6, IL-8, and serum CRP after SG (all p < 0.05). Insulin resistance improved remarkably after surgery as displayed by reductions in fasting insulin level (FINS, p < 0.001), and HOMA-IR (p < 0.001). In addition, visceral fat area (VFA) decreased from 209.70 ± 39.96 cm 2 to 193.28 ± 43.68 cm 2 after SG (p < 0.001). LPS was positively correlated with FINS (r = 0.391, p = 0.033) and HOMA-IR (r = 0.38, p = 0.038) before SG. Meanwhile, VFA was positively associated with CRP (r = 0.388, p = 0.034) before surgery. When assessing 30-days postoperative changes, a positive correlation was found between the variations of LPS, IL-8 and the reduction of VFA. After multivariate analyses, only the reduced IL-8 level was independently associated with the reduction of VFA (p = 0.015). In conclusion, SG can significantly relieve the inflammation in obesity in the short term and LPS might be an earlier predictor of inflammatory changes after surgery.

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Toll-like receptor signaling and serum levels of interferon β and lipopolysaccharide binding protein are related to abdominal obesity: a case-control study between metabolically healthy and metabolically unhealthy obese individuals

Cited by 10 publications

References 42 publications

Postprandial Endotoxin Transporters LBP and sCD14 Differ in Obese vs. Overweight and Normal Weight Men during Fat-Rich Meal Digestion

Postprandial Endotoxin Transporters LBP and sCD14 Differ in Obese vs. Overweight and Normal Weight Men during Fat-Rich Meal Digestion

<p>The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions</p>

Lipopolysaccharide and inflammatory cytokines levels decreased after sleeve gastrectomy in Chinese adults with obesity

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