Toll-like receptor recognition of bacteria in fish: Ligand specificity and signal pathways

Zhang, Jie; Kong, Xianghui; Zhou, Chuanjiang; Li, Li; Nie, Guoxing; Li, Xuejun

doi:10.1016/j.fsi.2014.09.022

Cited by 260 publications

(126 citation statements)

References 113 publications

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“…Pattern recognition receptors (PRRs) recognize the conserved molecular structure of pathogens and trigger the signaling pathways that activate immune cells in response to pathogen infection. Toll-like receptors (TLRs) are the first and best characterized innate immune receptors [10]. The TLR2 is capable of recognizing a broad spectrum of microbes, partly due to its ability to form heterodimers with TLR1 and TLR6 [11].…”

Section: Introductionmentioning

confidence: 99%

Repeated handling compromises the immune suppression and improves the disease resistance in overwintering channel catfish (Ictalurus punctatus)

Yang

Wang

et al. 2015

Fish & Shellfish Immunology

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Section: Introductionmentioning

confidence: 99%

Repeated handling compromises the immune suppression and improves the disease resistance in overwintering channel catfish (Ictalurus punctatus)

Yang

Wang

et al. 2015

Fish & Shellfish Immunology

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“…5, Table S3). These 258 pathways were subjected to six categories: human diseases (24,263, 79.43%), organismal systems (18,279,59.83%), metabolism (11,248,36.82%), cellular processes (8,081, 26.45%), environmental information processing (8,066, 26.4%), and genetic information processing (5,377, 17.6%). Among these unigenes, a total of 6075 unigenes were grouped into the cluster of immune system and further classified into 15 immune-related pathways.…”

Section: Go Cog and Kegg Classification Of Transcriptome Sequencesmentioning

confidence: 99%

“…Currently, at least 20 TLR types have been identified in fish species including TLR1, 2, 3, 4, 5, 7, 8, 9, 13, 14, 18e26, while only 13 TLR types (TLR1-13) found in mammals, indicating that TLRs have been massively expanded in fish [36]. In the present study, several TLRs reported previously were first identified in soiny mullet, including TLR1, 2, 3, 4, 5M, 6, 7, 8-1, 9, 13, 14, 15, 18, 22, and 23 which confirmed by phylogenetic tree (Fig.…”

Section: Tlrs and Tlr-pathways Of The Soiny Mulletmentioning

confidence: 99%

“…Interestingly, TLR4 which was present in some but not all fish species was found in soiny mullet and up-regulated for 7.3-fold after S. dysgalactiae infection. Mammalian TLR4 recognizes the LPS, the major component of the membrane of gramnegative bacteria [39], whilst fish TLR4 seems to possess more functions than that of mammals which had been proved to recognize ligands of gram negative bacterial, fungal, protistan, helminthic and virus [36]. It was speculated that fish TLR4 might involve in immune response of gram-positive bacteria.…”

Section: Tlrs and Tlr-pathways Of The Soiny Mulletmentioning

confidence: 99%

“…Modified from Ref. [36]. The molecules found in soiny mullet were color marked in and molecules (TRAM and IRAK4) had not been found in fish were marked in white.…”

Section: Identification Of Ssrs and Snpsmentioning

confidence: 99%

See 2 more Smart Citations

Transcriptome analysis of soiny mullet (Liza haematocheila) spleen in response to Streptococcus dysgalactiae

Zhang

et al. 2016

Fish & Shellfish Immunology

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Spotted Gar and the Evolution of Innate Immune Receptors

et al. 2017

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The resolution of the gar genome affords an opportunity to examine the diversification and functional specialization of immune effector molecules at a distant and potentially informative point in phylogenetic development. Although innate immunity is effected by a particularly large number of different families of molecules, the focus here is to provide detailed characterization of several families of innate receptors that are encoded in large multigene families, for which orthologous forms can be identified in other species of bony fish but not in other vertebrate groups as well as those for which orthologs are present in other vertebrate species. The results indicate that although teleost fish and the gar, as a holostean reference species, share gene families thought previously to be restricted to the teleost fish, the manner in which the members of the multigene families of innate immune receptors have undergone diversification is different in these two major phylogenetic radiations. It appears that both the total genome duplication and different patterns of genetic selection have influenced the derivation and stabilization of innate immune genes in a substantial manner during the course of vertebrate evolution.

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Toll-like receptor recognition of bacteria in fish: Ligand specificity and signal pathways

Cited by 260 publications

References 113 publications

Repeated handling compromises the immune suppression and improves the disease resistance in overwintering channel catfish (Ictalurus punctatus)

Repeated handling compromises the immune suppression and improves the disease resistance in overwintering channel catfish (Ictalurus punctatus)

Transcriptome analysis of soiny mullet (Liza haematocheila) spleen in response to Streptococcus dysgalactiae

Spotted Gar and the Evolution of Innate Immune Receptors

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