Toll‐like receptor 9 signaling in chronic lymphocytic leukemia cell lines
Miriam Meloni,
Ilenia Sana,
Maria Elena Mantione
et al.
Abstract:Chronic lymphocytic leukemia (CLL) is a prototypic neoplasia in which malignant cells strongly depend on microenvironmental stimulations in the lymphoid tissues where they accumulate; leukemic cells are exposed to interaction with bystander and accessory cells, as well as inflammatory soluble mediators. Cell lines are frequently used to model the pathobiology of this disease; however, they do not always recapitulate leukemic cell growth and response to stimulation, and no data are available on Toll‐like recept… Show more
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