Toll-like receptor 3 -926T&gt;A increased the risk of breast cancer through decreased transcriptional activity

Fan, Lei; Zhou, Peng; Chen, Ao-Xiang; Li, Guangyu; Yu, Ke-Da; Shao, Zhi‐Ming

doi:10.1080/2162402x.2019.1673126

Cited by 12 publications

(9 citation statements)

References 21 publications

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“…It is presumed that NOVA2 worked for the metastasis of non-small-cell lung cancer (NSCLC) [ 75 ], colorectal cancer [ 76 ], and ovarian tumor [ 77 ] since its overexpression in these three cases. As an endosomal pattern-recognition receptor, TLR3 mediates innate immune response [ 78 ] and is found to induce apoptosis and thus result in oncogenesis, for instance, prostate cancer [ 79 ], non-small-cell lung cancer (NSCLC), breast cancer [ 80 ], colon cancer [ 81 ], papillary thyroid cancer [ 82 ], and nasopharyngeal carcinoma [ 83 ] as well as head and neck cancer [ 84 ]. By promoting oxidative phosphorylation and mitochondrial biogenesis, the activated PPARGC1A might accelerate metastasis [ 85 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated Analysis of the Roles of RNA Binding Proteins and Their Prognostic Value in Clear Cell Renal Cell Carcinoma

Wang

Zhao

et al. 2021

Journal of Healthcare Engineering

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Background and Purpose. The renal cell carcinoma is one of the main malignant tumors in the genitourinary system, which seriously affects human health. Unregulated expression of RNA binding proteins (RBPs) is thought to be involved in the progression of many cancers. However, the role of RBPs in the clear cell renal cell carcinoma (ccRCC) is not yet clear. Methods. We downloaded the RNA sequencing data of ccRCC from the Cancer Genome Atlas (TCGA) database and identified differently expressed RBPs in different tissues. In this study, we used bioinformatics to analyze the expression and prognostic value of RBPs; then, we performed functional analysis and constructed a protein interaction network for them. We also screened out some RBPs related to the prognosis of ccRCC. Finally, based on the identified RBPs, we constructed a prognostic model that can predict patients’ risk of illness and survival time. Also, the data in the HPA database were used for verification. Results. In our experiment, we obtained 539 ccRCC samples and 72 normal controls. In the subsequent analysis, 87 upregulated RBPs and 38 downregulated RBPs were obtained. In addition, 9 genes related to the prognosis of patients were selected, namely, RPL36A, THOC6, RNASE2, NOVA2, TLR3, PPARGC1A, DARS, LARS2, and U2AF1L4. We further constructed a prognostic model based on these genes and plotted the ROC curve. This ROC curve performed well in judgement and evaluation. A nomogram that can judge the patient’s life span is also made. Conclusion. In conclusion, we have identified differentially expressed RBPs in ccRCC and carried out a series of in-depth research studies, the results of which may provide ideas for the diagnosis of ccRCC and the research of new targeted drugs.

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Section: Discussionmentioning

confidence: 99%

Integrated Analysis of the Roles of RNA Binding Proteins and Their Prognostic Value in Clear Cell Renal Cell Carcinoma

Wang

Zhao

et al. 2021

Journal of Healthcare Engineering

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“…The underlying mechanism might be that TLR3 gene polymorphism influences the level of inflammatory factors, thus affecting virus clearance and pro-inflammatory response signals at different disease stages. [ 31 ] Fan et al found that the TLR3 gene rs5743305 polymorphism may be associated with increased susceptibility to breast cancer due to the reduced ability of TLR3 to recognize double-stranded RNA (dsRNA) and induce apoptosis in human breast cancer cells, [ 32 ] and Chen DN et al found that the TLR3 rs3775291 polymorphism was associated with the recurrence of breast cancer. In addition, considering the rs3775291 polymorphism, advanced dry age-related macular degeneration, hepatitis C virus (HCV) infection, chronic hepatitis caused by hepatitis B virus (HBV), and hepatitis B-related acute-on-chronic liver failure were confirmed to be affected mainly by the reduced signaling activity of TLR3 and the ability to bind to dsRNA or influence its glycosylation.…”

Section: Discussionmentioning

confidence: 99%

Association of TLR3 gene 1377C/T (rs3775290) and TLR7 gene C/G (rs3853839) polymorphism with hand, foot, and mouth disease caused by human enterovirus 71 infection susceptibility and severity in the Chinese Han population: A meta-analysis of case-control studies

Tian

Wen

et al. 2022

Medicine

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Background: Several case-control studies have been conducted on the relationship between rs3775290 C/T and rs3853839 C/G single nucleotide polymorphisms of the Toll-like receptor (TLR) gene and hand, foot, and mouth disease (HFMD) susceptibility and severity. This meta-analysis aimed to offer a systemic review of HFMD susceptibility and severity among the Chinese Han population associated with the C/T (rs3775290) polymorphism of the TLR3 gene or C/G (rs3853839) polymorphism of the TLR7 gene. Methods: A computer search was conducted using PubMed, Web of Science, Embase, CNKI, CBM, VIP, and WanFang databases. The time ranges were from database establishment to 30/7/2021. Articles selected according to the inclusion and exclusion criteria underwent data extraction and methodological quality evaluation. RevMan 5.4 and Stata 16.0 were adopted for meta-analysis, and the incorporated odds ratio (OR) values and 95% confidence intervals (CIs) were calculated. Sensitivity and publication bias assessments were performed. Results: 8 articles with 9 studies were selected. Among them, there were 858 cases and 577 controls in TLR3 rs3775290 studies as well as 2151 cases and 1554 controls in TLR7 rs3853839 studies. Regarding rs3775290 of TLR3, susceptibilities of the severe type of T-possessing individuals were larger than those of C-possessing individuals [OR = 1.34, 95%CI (1.10, 1.64), P = .004]. The susceptibility of individuals with the severe TT genotype was 1.61 times that of individuals with the CC genotype [95%CI (1.07, 2.43), P=0.02], while susceptibility to HFMD was not influenced by the genotype. In terms of the rs3853839 of the TLR7 gene, C allele carriers have a higher risk of developing HFMD than G allele carriers. The susceptibility to HFMD in CC+CG individuals was 1.24 times than that in GG individuals [95%CI (1.07, 1.43), P = .004]. However, no relationship was found between this polymorphism and severity of the severe type. No significant publication bias was observed in this study. Conclusions: rs3775290 (C/T) of TLR3 is associated with susceptibility to the severe type, whereas rs3853839 (C/G) of TLR7 is associated with susceptibility to HFMD. However, owing to the limited quantity and quality of the research, the aforementioned conclusions are yet to be justified by more high-quality research.

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“…[12] Triple-negative breast cancer is more sensitive to immunotherapy than other subtypes. [4,22,23] Previous studies also suggested that Siglec-15 is an immune suppressor of T cells. [12] Therefore, high expression of Siglec-15 leads to poor survival in triple-negative breast cancer.…”

Section: Discussionmentioning

confidence: 99%

High Siglec-15 Expression in Triple-negative Breast Cancer Predicts Poor Prognosis

Fan

Sui

Yang

et al. 2022

Preprint

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Introduction: Normalization cancer immunotherapy is a new strategy to treat breast cancer. Sialic acid binding Ig-like lectin 15 (Siglec-15) is a new potential target for normalization cancer immunotherapy. In this study, we evaluated the role of Siglec-15 in breast cancer and investigated the influence of Siglec-15 on the microenvironment of infiltrating immune cells in cancer. Methods We performed immunohistochemical staining to analyse Siglec-15 expression in primary invasive breast cancer tissue microarrays. The tissue specimens were from 90 patients. Furthermore, the relationship between Siglec-15 and clinicopathological features was analysed with logistic regression and the Wilcoxon signed-rank test. The association between clinical characteristics and overall survival in The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) patients was assessed. Results Immunohistochemical staining of tissue microarrays showed that Siglec-15 had higher expression in breast cancer tissues than in adjacent normal tissues. Breast cancer tissues had higher Siglec-15 expression than normal tissues did. Kaplan–Meier survival analysis suggested that triple-negative breast cancer with high Siglec-15 expression had poorer survival than those with lower Siglec-15 expression (p = 0.042). Furthermore, the high Siglec-15 expression group had low activated dendritic cells, follicular helper T cells, and M1 macrophages. Conclusions Siglec-15 had a high expression in breast cancer tissues. High Siglec-15 expression is associated with low activated dendritic cell, follicular helper T cell, and M1 macrophage proportions in breast cancer tissue and predicts poor prognosis in triple-negative breast cancer. Siglec-15 expression may be a potential prognostic molecular marker of poor survival in breast cancer.

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Toll-like receptor 3 -926T>A increased the risk of breast cancer through decreased transcriptional activity

Cited by 12 publications

References 21 publications

Integrated Analysis of the Roles of RNA Binding Proteins and Their Prognostic Value in Clear Cell Renal Cell Carcinoma

Integrated Analysis of the Roles of RNA Binding Proteins and Their Prognostic Value in Clear Cell Renal Cell Carcinoma

Association of TLR3 gene 1377C/T (rs3775290) and TLR7 gene C/G (rs3853839) polymorphism with hand, foot, and mouth disease caused by human enterovirus 71 infection susceptibility and severity in the Chinese Han population: A meta-analysis of case-control studies

High Siglec-15 Expression in Triple-negative Breast Cancer Predicts Poor Prognosis

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