Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris

Hasegawa, Takashi; Matsuguchi, Tetsuya; Noda, Kiyoshi; Tanaka, Kuniaki; Kumamoto, Shoichiro; Shoyama, Yukihiro; Yoshikai, Yasunobu

doi:10.1016/s1567-5769(02)00002-4

Cited by 55 publications

(43 citation statements)

References 45 publications

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“…Extracts of C. vulgaris are well known as potent biological response modifiers that regulate immune responses against bacteria [Hasegawa et al, 1995], viruses [Ibusuki and Minamishima, 1990], tumors [Justo et al, 2001;Hasegawa et al, 2002] and even native antigens such as casein . Biomass of C. vulgaris provided by industrial cultivation has been consumed as health food for years [Kittaka-Katsura et al, 2002;Pulz and Gross, 2004].…”

Section: Introductionmentioning

confidence: 99%

Effects of magnetic field on the antioxidant defense system of recirculation‐cultured Chlorella vulgaris

Wang

Zeng

Guo

et al. 2007

Bioelectromagnetics

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Little is known about the influence of magnetic fields (MF) on growth of microalgae such as Chlorella vulgaris, which has been consumed as health food for various nutritional and pharmacological effects. This preliminary study investigated whether static MF can modulate the antioxidant system in C. vulgaris by exposing the cells to static MF generated by dual yoke electromagnets with magnetic flux density of 10-50 mT for 12 h. After exposure to 10-35 mT for 12 h, the activity of superoxide dismutases and peroxidase increased significantly compared to control cells. However, a remarkable increase of catalase activity occurred at 45 and 50 mT. The lipid peroxidation of algae cells determined by production of thiobarbituric acid-reactive substances was much increased when exposed to 35, 45, and 50 mT of MF. The scavenging ability of 2,2-diphenyl-1-picrylhydrazyl radical was decreased markedly while there was no variation of total carotenoids content in C. vulgaris cells. Assay of specific growth rate in 72 h cultivation after MF exposure was also conducted. In groups after exposure to 10-35 mT of MF, specific growth rate was significantly increased. These results suggest that 10-35 mT of static MF exposure could promote the growth of C. vulgaris and regulate its antioxidant defense system to protect cells efficiently, which could possibly enhance the growth of C. vulgaris in industrialized cultivation by MF.

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Section: Introductionmentioning

confidence: 99%

Effects of magnetic field on the antioxidant defense system of recirculation‐cultured Chlorella vulgaris

Wang

Zeng

Guo

et al. 2007

Bioelectromagnetics

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“…Second, it has been reported to have certain beneficial physiological effects, such as y To whom correspondence should be addressed. Fax: +81-42-577-3020; E-mail: shinya-shibata@yakult.co.jp Abbreviations: ABC, ATP-binding cassette; CB, cholesterol + bile acid; CIF, Chlorella indigestible fraction; CP, Chlorella powder; CYP7A1, cholesterol 7-hydroxylase; CYP27A1, sterol 27-hydroxylase; FXR, farnesoid X receptor; HDL, high density lipoprotein; HNF-4, hepatocyte nuclear factor 4; HMGR, HMG-CoA reductase; LDL, low-density lipoprotein; LDLR, LDL receptor; LRH-1, liver receptor homolog-1; LXR, liver X receptor ; PCR, polymerase chain reaction; SHP, short heterodimer partner; SR-B1, scavenger receptor class B1; SREBP-2, sterol regulatory element-binding protein 2; TG, triglyceride hypocholesterolemic, [9][10][11][12] antihypertensive, 13) antioxidative, 14,15) and anti-tumor 16,17) activities in animal and human studies.…”

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confidence: 99%

Hypocholesterolemic Mechanism ofChlorella:Chlorellaand Its Indigestible Fraction Enhance Hepatic Cholesterol Catabolism through Up-Regulation of Cholesterol 7α-Hydroxylase in Rats

Shibata

Hayakawa

Egashira

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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“…Extracts of C. vulgaris has previously been reported to show antitumour effect in fibrobsarcomas (Konishi et al, 1985;Hasegawa et al, 2002). Furthermore, the algal extract has also been shown to exhibit possible anticancer properties in : Comets analysis by fluorescence microscopy with visual inspection of tail length of nuclei.…”

Section: Discussionmentioning

confidence: 99%

<i>Chlorella vulgaris</i> modulates hydrogen peroxide-induced dna damage and telomere shortening of human fibroblasts derived from different aged individuals

Makpol

Yaacob

Zainuddin

et al. 2010

Afr. J. Trad. Compl. Alt. Med.

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The objective of this study was to investigate the modulatory effect of Chlorella vulgaris on cultured fibroblast cells derived from young and old aged individuals focusing on DNA damage, telomere length and telomerase activity. Dose-response test of the algal extract on cells in both age groups revealed that optimum viability was observed at a concentration of 50 μg/ml. Results obtained showed that Chlorella vulgaris exhibited protective effects against H 2 O 2 -induced oxidative stress as shown by the reduction in damaged DNA caused by H 2 O 2 treatment (p<0.05) in Chlorella vulgaris pre-and post-treated groups (p<0.05). Pre-treatment of Chlorella vulgaris resulted in a significant decrease in DNA damage suggesting a bioprotective effect against free radical attacks. A decline in DNA damage was observed in post-treated cells which proves Chlorella vulgaris to present bioremediative properties. In cells induced with oxidative stress, telomere length decreased significantly coupled with a concomitant decline of telomerase activity (p<0.05). However, these reductions were prevented with prior and post treatment of Chlorella vulgaris. Therefore, we concluded that Chlorella vulgaris exhibited bioprotective effects especially in cells obtained from young donor but were more bioremediative for cells obtained from old donor as indicated by DNA damage, telomere shortening and reduction in telomerase activity.

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Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris

Cited by 55 publications

References 45 publications

Effects of magnetic field on the antioxidant defense system of recirculation‐cultured Chlorella vulgaris

Effects of magnetic field on the antioxidant defense system of recirculation‐cultured Chlorella vulgaris

Hypocholesterolemic Mechanism ofChlorella:Chlorellaand Its Indigestible Fraction Enhance Hepatic Cholesterol Catabolism through Up-Regulation of Cholesterol 7α-Hydroxylase in Rats

<i>Chlorella vulgaris</i> modulates hydrogen peroxide-induced dna damage and telomere shortening of human fibroblasts derived from different aged individuals

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