Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and susceptibility to asthma and allergic rhinitis: A case–control analysis

Hussein, Yousri M.; Awad, Hanan; Shalaby, Sally M.; Ali, Alshaymaa Ahmed; Alzahrani, Saleh

doi:10.1016/j.cellimm.2012.02.006

Cited by 42 publications

(34 citation statements)

References 30 publications

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“…The coexistence of a parental history of AD and factors related to mold exposure, such Some studies show that TLR4 polymorphisms may have a role in the development of Th2-dominant allergic inflammation. 28,29) In this study, there was no significant association between the TLR4 (rs1927911) polymorphism and development of AD. However, the risk of AD was increased by mold exposure in children with the CC genotype of TLR4 polymorphism.…”

Section: Discussioncontrasting

confidence: 55%

Gene-environment interaction between Toll-like receptor 4 and mold exposure in the development of atopic dermatitis in preschool children

Kim

Jung

Hong

et al. 2013

Allergy Asthma Respir Dis

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Purpose: Genetic factors and environmental exposures are recognized as important risk factors for atopic dermatitis (AD) in children. Inflammatory responses by molds can be mediated via Toll-like receptor 4 (TLR4). The aims of this study were to investigate mold as risk factor of AD and gene-environment interaction on AD in preschool children. Methods: We undertook a cross-sectional survey with 986 preschool children. We investigated five mold exposure measures (dampness stain, dampness damage, visible mold, mold odor, and house repair). The TLR4 polymorphism (rs1927911) was genotyped by TaqMan assay. Results: The prevalence of AD was as follows: AD diagnosis by questionnaire, 35.1%; current AD (lifetime diagnosis together with symptoms in the last 12 months), 21.5%. When children with parental history of AD were exposed to mold odor during infancy and house repair during the last 12 months, the risk for current AD (adjusted odds ratio [aOR], 6.826; 95% confidence interval [CI], 2.511 to 18.554 vs. aOR, 6.143; 95% CI, 2.348 to 16.074) was further increased than only with parental history of AD. In children with the CC genotype of TLR4 polymorphism, the risk of AD was increased by mold exposure. Conclusion: This investigation identified that mold exposure is potential risk factor for AD in preschool children. Parental history of AD and mold exposure during infancy and the last 12 months had synergistic effect on high prevalence of AD. We identified that mold exposure andTLR4 polymorphism have an effect on the development of atopic dermatitis. (��

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Section: Discussioncontrasting

confidence: 55%

Gene-environment interaction between Toll-like receptor 4 and mold exposure in the development of atopic dermatitis in preschool children

Kim

Jung

Hong

et al. 2013

Allergy Asthma Respir Dis

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“…Polymorphisms of TLR2 deteriorate the function of proteins associated with certain diseases, for example, the TLR2 Arg753Gln polymorphism is associated with an increased risk of infective endocarditis (5), vitiligo (6) and atopic derma (7). Although the results of Hussein et al (8) indicated that the genotype and allele frequencies of TLR2 Arg753Gln were not associated with asthma or allergic rhinitis, a significant correlation with disease severity was observed. Brown et al (9) reported that this mutation may abrogate TLR2 signaling in response to human cytomegalovirus.…”

Section: Introductionmentioning

confidence: 99%

Association of Toll-like receptor 2 polymorphisms with gout

et al. 2014

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Abstract. Gout is the most common autoinflammatory arthritis characterized by elevated serum urate and recurrent attacks of intra-articular crystal deposition of monosodium urate (MSU) in tissues. The pathogenesis of gout has not been fully determined, although certain genetic factors are involved in the development of gout. Accumulated data suggested that MSU crystal-induced inflammation is a paradigm of innate immunity. As Toll-like receptors (TLRs) are the underlying mechanisms of the innate immune response, the present study aimed to investigate whether TLR2 polymorphisms are associated with gout. Two single-nucleotide polymorphisms (Arg677Trp and Arg753Gln, rs5743708) in TLR2 were genotyped by polymerase chain reaction-restriction fragment length polymorphism and the -196 to -174 del polymorphism was investigated using the allele-specific polymerase chain reaction in 431 individuals (215 patients with gout and 216 healthy controls). TLR2 Arg677Trp and Arg753Gln genotyping indicated that all the positive samples were of the wild-type genotype. No significant differences in genotype (χ 2 =1.686, P=0.430) and allele (χ 2 =1.430, P=0.232) frequencies of the -196 to -174 del polymorphism between the patients with gout and the control groups was observed. Our results suggested that the TLR2 Arg677Trp, Arg753Gln and the -196 to -174 del polymorphisms were not associated with susceptibility to primary gouty arthritis.

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“…Several studies have reported that certain CD14 polymorphisms may lead to a more severe allergic reaction, that is, a stronger IgE response (6,9,19,21,25). In contrast, polymorphisms of Toll-like receptors 2 and 4, which are LPS receptors too, were not associated with allergy and asthma when compared with controls (43).…”

Section: Discussionmentioning

confidence: 66%

Soluble CD14 and total IgE in the serum of atopic and nonatopic adolescents in relation to environmental factors: a pilot study / Topivi receptor CD14 i ukupni IgE u serumu mladih atopičara odrasle dobi u ovisnosti o čimbenicima iz okoliša: pilot istraživanje

Prester

Varnai

Macan

2015

Archives of Industrial Hygiene and Toxicology

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The CD14 receptor is expressed on the surfaces of monocytes, macrophages, and, to a lesser extent, of activated granulocytes and B lymphocytes (mCD14). It also exists in soluble form in the serum (sCD14), in which it binds microbial compounds and indoor allergens. The objectives of this study were to see whether serum sCD14 concentrations could be used as a marker of atopic disorders and to estimate the effects of environmental factors (tobacco smoke exposure, childhood residence in urban or rural areas, and having a pet) on sCD14 and IgE values. Mass fraction of sCD14 and total IgE were determined in the sera of atopic (N=53) and non-atopic (N=35) participants using the standard enzyme-linked immunosorbent assay. Exposure to pets and environmental tobacco smoke was estimated based on the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC). Median sCD14 concentration was significantly lower in atopic than in non-atopic girls (3.49 vs. 3.83 μg mL -1 ; p<0.010). The number of smokers at home positively correlated with the sCD14 level in atopics, and urban atopics had significantly lower sCD14 levels than rural atopics (3.47 vs. 3.92 μg mL -1 , p=0.028). Median total IgE concentration was significantly lower in atopic pet owners than in atopics with no pets (161 vs. 252 kIU L -1 ; p=0.021). In conclusion, while sex and environmental factors might be involved in sCD14 expression, particularly in atopics, we found no correlation between sCD14 and total IgE concentrations. The usefulness of sCD14 as a marker of atopic disorders should be investigated further, particularly in relation to the severity of allergic disorders.KEY WORDS: allergy; atopy; environmental tobacco smoke; immunoglobulin E; sCD14; pets Prester Lj, et al. Soluble CD14 and total IgE in the serum of atopic and non-atopic adolescents in relation to environmental factors: a pilot study Arh Hig Rada Toksikol 2015;66:41-49

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Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and susceptibility to asthma and allergic rhinitis: A case–control analysis

Cited by 42 publications

References 30 publications

Gene-environment interaction between Toll-like receptor 4 and mold exposure in the development of atopic dermatitis in preschool children

Gene-environment interaction between Toll-like receptor 4 and mold exposure in the development of atopic dermatitis in preschool children

Association of Toll-like receptor 2 polymorphisms with gout

Soluble CD14 and total IgE in the serum of atopic and nonatopic adolescents in relation to environmental factors: a pilot study / Topivi receptor CD14 i ukupni IgE u serumu mladih atopičara odrasle dobi u ovisnosti o čimbenicima iz okoliša: pilot istraživanje

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