Tolerant and diverse natural killer cell repertoires in the absence of selection

Andersson, Sandra; Malmberg, Jenny‐Ann; Malmberg, Karl‐Johan

doi:10.1016/j.yexcr.2010.02.030

Cited by 13 publications

(8 citation statements)

References 46 publications

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“…These results show that although CD158b is very important and abundant inhibitory NK cell receptor, it is not the only inhibitory receptor. The heterodimeric CD94-NKG2A receptor, appearing early in NK cell development before KIRs [49], has a big role in NK cell inhibition by recognizing HLA-E, nonclassic MHC-I molecule [50], which could be some kind of representation of the overall target cell expression of MHC class I molecules that are down-modulating in the process of malignant transformation [51].…”

Section: Discussionmentioning

confidence: 99%

The Stage Dependent Changes in NK Cell Activity and the Expression of Activating and Inhibitory NK Cell Receptors in Melanoma Patients

Martinović

Konjević

Babović

et al. 2011

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

The Stage Dependent Changes in NK Cell Activity and the Expression of Activating and Inhibitory NK Cell Receptors in Melanoma Patients

Martinović

Konjević

Babović

et al. 2011

Journal of Surgical Research

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“…Combined with genetic variability of the KIR/Ly49 locus at the levels of gene content, copy number variation, and allelic polymorphism, stochastic expression results in highly diverse NK cell repertoires in different populations. In human, the expression of KIR in combination with presence of one or more of four major MHC class I ligands (HLA‐C1, HLA‐C2, HLA‐Bw4, and HLA‐A3/A11), endow the majority of NK cells with at least one inhibitory KIR specific for a self‐MHC molecule . Despite the fact that the random distribution of KIR/Ly49 also leads to significant proportions of NK cells that altogether lack self‐specific inhibitory receptors in both mice and humans , self‐receptor expression still represents the major mechanism in the maintenance of self‐tolerance.…”

Section: Natural Killer Cell Repertoire Diversity: Tolerance and Funcmentioning

confidence: 99%

Newtonian cell interactions shape natural killer cell education

Goodridge

Önfelt

Malmberg

2015

Immunological Reviews

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SummaryNewton's third law of motion states that for every action on a physical object there is an equal and opposite reaction. The dynamic change in functional potential of natural killer (NK) cells during education bears many features of such classical mechanics. Cumulative physical interactions between cells, under a constant influence of homeostatic drivers of differentiation, lead to a reactive spectrum that ultimately shapes the functionality of each NK cell. Inhibitory signaling from an array of self‐specific receptors appear not only to suppress self‐reactivity but also aid in the persistence of effector functions over time, thereby allowing the cell to gradually build up a functional potential. Conversely, the frequent non‐cytolytic interactions between normal cells in the absence of such inhibitory signaling result in continuous stimulation of the cells and attenuation of effector function. Although an innate cell, the degree to which the fate of the NK cell is predetermined versus its ability to adapt to its own environment can be revealed through a Newtonian view of NK cell education, one which is both chronological and dynamic. As such, the development of NK cell functional diversity is the product of qualitatively different physical interactions with host cells, rather than simply the sum of their signals or an imprint based on intrinsically different transcriptional programs.

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“…Notably, the KIR repertoire is mainly determined genetically, but it is also influenced by the HLA class I genotype. 4,17,18 Umbilical CB transplantation (UCBT) is being widely used to treat patients affected by many disorders of both hematologic and nonhematologic origin. 19 In comparison to BM transplantation (BMT), UCBT offers the advantages of an easier procurement with no risk for the donor.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?

Chiesa

Falco

Podestà

et al. 2012

Blood

230

190

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Natural killer (NK) cells play a crucial role in early immunity after hematopoietic stem cell transplantation because they are the first lymphocyte subset recovering after the allograft. In this study, we analyzed the development of NK cells after intrabone umbilical cord blood (CB) transplantation in 18 adult patients with hematologic malignancies. Our data indicate that, also in this transplantation setting, NK cells are the first lymphoid population detectable in peripheral blood.

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Tolerant and diverse natural killer cell repertoires in the absence of selection

Cited by 13 publications

References 46 publications

The Stage Dependent Changes in NK Cell Activity and the Expression of Activating and Inhibitory NK Cell Receptors in Melanoma Patients

The Stage Dependent Changes in NK Cell Activity and the Expression of Activating and Inhibitory NK Cell Receptors in Melanoma Patients

Newtonian cell interactions shape natural killer cell education

Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?

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