Tolerance, Xenotransplantation: Future Therapies

Weiss, Matthew J.; Ng, Choo; Madsen, Joren C.

doi:10.1016/j.suc.2006.06.016

Cited by 10 publications

(5 citation statements)

References 75 publications

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“…Immune rejection and ischemia-reperfusion injury after transplantation are two main reasons for loss of the graft [ 1 ]. Therefore, approaches to minimize rejection and induction of immune tolerance may be used to effectively address the above problems [ 2 ]. Clinical treatment of acute rejection (ACR) after LTx requires high doses of immunosuppressants.…”

Section: Introductionmentioning

confidence: 99%

Improvement of Liver Transplantation Outcome by Heme Oxygenase‐1‐Transduced Bone Marrow Mesenchymal Stem Cells in Rats

Song

Yang

et al. 2016

Stem Cells International

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Bone marrow mesenchymal stem cells (BMMSCs) exert immunosuppressive activity in transplantation, and heme oxygenase-1 (HO-1) enhances their immunomodulatory effects. The aim of this study was to determine whether HO-1-transduced BMMSCs (HO-1/MSCs) improve rat liver transplantation (LTx) outcomes. Orthotopic LTx rejection models were treated with HO-1/MSCs, BMMSCs, HO-1, or normal saline, respectively. Our results showed a significant improvement in survival rates in the HO-1/BMMSCs group compared to the control groups. At all time points, liver function marker levels in the HO-1/MSCs group were significantly lower than in the other three groups; on POD 1, 7, and 14, the degree of rejection and apoptotic cells was significantly less in the HO-1/MSCs group than in the other three groups. Interleukin- (IL-) 10 and transforming growth factor-β levels were significantly increased, while IL-2, IL-6, IL-17, IL-23, tumor necrosis factor-α, and interferon-γ levels were significantly decreased in the HO-1/MSCs group when compared to the other groups. Splenocyte Tregs were significantly increased by HO-1/MSCs compared with controls on POD 3, 5, 7, 10, 14, and 28. Summarily, we provide evidence that HO-1/MSCs improved allogeneic LTx outcomes by attenuating inflammatory responses and acute cellular rejection, as well as enhanced immunomodulatory effects compared with BMMSCs.

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Section: Introductionmentioning

confidence: 99%

Improvement of Liver Transplantation Outcome by Heme Oxygenase‐1‐Transduced Bone Marrow Mesenchymal Stem Cells in Rats

Song

Yang

et al. 2016

Stem Cells International

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“…Також метод мікроінкапсуляції ткани-ни або клітин дає змогу вирішити одну з основних проблем трансплантології: від-сутність достатньої кiлькості донорського матеріалу [15,20]. Багато дослiдникiв на-магаються вирiшити це питання, вважаючи, що ксенотрансплантацiя (пересадка органiв i тканин вiд тварин людинi) є цiлком реальним виходом з цього становища.…”

Section: вступunclassified

Characteristization of microencapsulated human adrenal cortex tissue in long-term culture

PASTEUR¹,

Levchuk²,

Тronko³

2014

Fiziol Zh

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“…During the period, September–October 2006, three reviews of relevance to xenotransplantation were published [1–3]. Rozga [1] reviewed liver support strategies, such as blood purification devices and cell‐based techniques.…”

Section: Reviewsmentioning

confidence: 99%

“…Weiss et al [3] reviewed the present status of tolerance induction in xenotransplantation and discussed future therapies to improve graft acceptance and prevention of rejection in this field.…”

Section: Reviewsmentioning

confidence: 99%