Tolerance to Tremorine

Decsi, L; Várszegi, M.; Méhes, J.

doi:10.1111/j.2042-7158.1961.tb11800.x

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1962

1977

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Cited by 9 publications

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“…Each group consisted of 50-60 mice and was further subdivided into groups of 10 each for determining the EDso of tremorine analgesia. Tremorine tolerance was induced by injecting tremorine, 12 mg/kg s.c., daily for 6 days (Desci et al, 1961). Control groups received normal saline instead of tremorine.…”

Section: Methodsmentioning

confidence: 99%

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Possible involvement of 5-hydroxytryptamine and cyclic-AMP in tolerance to tremorine analgesia in mice

1977

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The phenomenon of tolerance to the analgesic action of tremorine in mice was studied by the hot-plate and tail-clip methods. Reduction in 5-HT levels in brain by parachlorophenylalamine pretreatment decreased the ED50 of tremorine analgesia in tremorine tolerant mice. 5-Hydroxyptophan, L-Dopa or alpha-methyl-para-tyrosine did not influence the analgesic response to tremorine in tremorine tolerant animals. However, theophylline was found to enhance the tolerance to tremorine analgesia. Brain 5-HT and cAMP are probably involved in tremorine tolerance, whereas neither noradrenaline nor dopamine is involved in the phenomenon.

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Section: Methodsmentioning

confidence: 99%

“…Tolerance develops rapidly to this analgesic action in mice on repeated administration (Desci et al, 1961). It has been reported that oxotremorine tolerance is associated with a reduction of the central effects of nicotine and physostigmine (Gyorgy et al, 1970).…”

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confidence: 98%